Up‐Regulated Interleukin‐10 Induced by E2F Transcription Factor 2–MicroRNA‐17‐5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 74; no. 3; pp. 496 - 507
• Main Authors: Xu, Lingxiao, Wang, Lei, Shi, Yumeng, Deng, Yun, Oates, Jim C., Kamen, Diane L., Gilkeson, Gary S., Wang, Fang, Zhang, Miaojia, Tan, Wenfeng, Tsao, Betty P.
• Format: Journal Article
• Language: English
• Published: Boston, USA Wiley Periodicals, Inc 01.03.2022; Wiley Subscription Services, Inc
• Subjects: 3' Untranslated regions; Adolescent; Adult; Aged; Antibodies; Antinuclear antibodies; Autoantibodies; Autoimmune diseases; B-Lymphocyte Subsets - metabolism; Cardiolipin; CD11c antigen; CD27 antigen; CD45RA antigen; Cell culture; Chronic conditions; Circuits; Correlation; CXCR3 protein; CXCR5 protein; Cytokines; Deoxyribonucleic acid; DNA; E2F protein; E2F Transcription Factors - metabolism; Effector cells; Female; Flow cytometry; Gene expression; Humans; Immunoglobulin D; Immunoglobulin G; Interleukin 1; Interleukin 10; Interleukin-10 - genetics; Interleukin-10 - metabolism; Interleukins; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Lupus; Lupus Erythematosus, Systemic - genetics; Lupus Erythematosus, Systemic - metabolism; Lymphocytes B; Male; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Peripheral blood mononuclear cells; Proteinuria; Ribonucleic acid; RNA; siRNA; Systemic lupus erythematosus; Transcription factors; Up-Regulation; Young Adult

Objective Elevated interleukin‐10 (IL‐10) levels in patients with systemic lupus erythematosus (SLE) have B cell–promoting effects, contributing to autoantibody production and tissue damage. We aimed to characterize up‐regulated IL‐10+ B cell subsets and dysregulated IL10 expression in SLE B cells f...