Inflammatory intrathecal profiles and cortical damage in multiple sclerosis

• Published in: Annals of neurology Vol. 83; no. 4; pp. 739 - 755
• Main Authors: Magliozzi, Roberta, Howell, Owain W., Nicholas, Richard, Cruciani, Carolina, Castellaro, Marco, Romualdi, Chiara, Rossi, Stefania, Pitteri, Marco, Benedetti, Maria Donata, Gajofatto, Alberto, Pizzini, Francesca B., Montemezzi, Stefania, Rasia, Sarah, Capra, Ruggero, Bertoldo, Alessandra, Facchiano, Francesco, Monaco, Salvatore, Reynolds, Richard, Calabrese, Massimiliano
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2018
• Subjects: Adult; Aged; Aged, 80 and over; APRIL protein; Autopsy; Biomarkers; BLyS protein; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - pathology; Cerebrospinal fluid; Cohort Studies; Cortex; CXCL10 protein; CXCL12 protein; CXCL13 protein; Cytokines; Cytokines - cerebrospinal fluid; Damage detection; Demyelination; Diagnosis; Disease Progression; Female; Gelatinase A; Gene expression; Gray Matter - diagnostic imaging; Gray Matter - pathology; Humans; Identification methods; Image Processing, Computer-Assisted; Inflammation; Interleukin 1; Interleukin 10; Interleukin 2; Interleukin 22; Interleukin 6; Interleukin 8; Light levels; Lymphocytes B; Magnetic Resonance Imaging; Male; Meninges; Meninges - diagnostic imaging; Meninges - metabolism; Middle Aged; Multiple sclerosis; Multiple Sclerosis - cerebrospinal fluid; Multiple Sclerosis - diagnostic imaging; Multiple Sclerosis - pathology; NMR; Nuclear magnetic resonance; Patients; ROC Curve; Substantia grisea; γ-Interferon

Objective Gray matter (GM) damage and meningeal inflammation have been associated with early disease onset and a more aggressive disease course in multiple sclerosis (MS), but can these changes be identified in the patient early in the disease course? Methods To identify possible biomarkers linking...