Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 69; no. 4; pp. 1768 - 1786
• Main Authors: Lee, Derek, Xu, Iris Ming‐Jing, Chiu, David Kung‐Chun, Leibold, Josef, Tse, Aki Pui‐Wah, Bao, Macus Hao‐Ran, Yuen, Vincent Wai‐Hin, Chan, Cerise Yuen‐Ki, Lai, Robin Kit‐Ho, Chin, Don Wai‐Ching, Chan, Daniel For‐Fan, Cheung, Tan‐To, Chok, Siu‐Ho, Wong, Chun‐Ming, Lowe, Scott W., Ng, Irene Oi‐Lin, Wong, Carmen Chak‐Lui
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.04.2019
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Antioxidants; Apoptosis; Auranofin - pharmacology; Auranofin - therapeutic use; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Cell proliferation; Drug Screening Assays, Antitumor; Gene expression; Hep G2 Cells; Hepatocellular carcinoma; Hepatology; Homeostasis; Humans; Intracellular; Kelch-Like ECH-Associated Protein 1 - metabolism; Kinases; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Mice; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Oxidative Stress - drug effects; Reactive oxygen species; Reductase; Sorafenib - therapeutic use; Thioredoxin; Thioredoxin Reductase 1 - antagonists & inhibitors; Thioredoxin Reductase 1 - metabolism; Transcription activation; Tumors

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal cancers worldwide which lacks effective treatment. Cancer cells experience high levels of oxidative stress due to increased generation of reactive oxygen species (ROS). Increased antioxidant‐producing capacity is therefore found...