Induction of Oxidative Stress Through Inhibition of Thioredoxin Reductase 1 Is an Effective Therapeutic Approach for Hepatocellular Carcinoma - Lee, Derek; Xu, Iris Ming‐Jing; Chiu, David Kung‐Chun; Leibold, Josef; Tse, Aki Pui‐Wah; Bao, Macus Hao‐Ran; Yuen, Vincent Wai‐Hin; Chan, Cerise Yuen‐Ki; Lai, Robin Kit‐Ho; Chin, Don Wai‐Ching; Chan, Daniel For‐Fan; Cheung, Tan‐To; et al. (Hepatology (Baltimore, Md.), 2019)
Keywords: Animals; Antineoplastic Agents - therapeutic use; Antioxidants; Apoptosis; Auranofin - pharmacology; Auranofin - therapeutic use; Carcinoma, Hepatocellular - drug therapy; Carcinoma, Hepatocellular - metabolism; Cell proliferation; Drug Screening Assays, Antitumor; Gene expression; Hep G2 Cells; Hepatocellular carcinoma; Hepatology; Homeostasis; Humans; Intracellular; Kelch-Like ECH-Associated Protein 1 - metabolism; Kinases; Liver cancer; Liver Neoplasms - drug therapy; Liver Neoplasms - metabolism; Mice; NF-E2-Related Factor 2 - metabolism; Oxidative stress; Oxidative Stress - drug effects; Reactive oxygen species; Reductase; Sorafenib - therapeutic use; Thioredoxin; Thioredoxin Reductase 1 - antagonists & inhibitors; Thioredoxin Reductase 1 - metabolism; Transcription activation; Tumors