Placental extracellular vesicles and pre‐eclampsia

Pre‐eclampsia is a hypertensive disease of pregnancy characterized by new‐onset hypertension, with either proteinuria and/or organ dysfunction. Pre‐eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. The...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of reproductive immunology (1989) Vol. 85; no. 2; pp. e13297 - n/a
Main Authors Schuster, Jessica, Cheng, Shi‐Bin, Padbury, James, Sharma, Surendra
Format Journal Article
LanguageEnglish
Published Denmark Wiley Subscription Services, Inc 01.02.2021
Subjects
Angiogenesis
Animals
Autophagy
Blood flow
Eclampsia
Extracellular vesicles
Extracellular Vesicles - metabolism
Female
Fetuses
Humans
Immune response
Immunity - immunology
Inflammation
Inflammation - immunology
Macromolecules
miRNA
Molecular modelling
Morbidity
Neovascularization, Pathologic
Nucleotides
Phagocytosis
Placenta
Placenta - metabolism
Pre-Eclampsia - immunology
Preeclampsia
Pregnancy
pre‐eclampsia
Proteinuria
placenta
pre-eclampsia
extracellular vesicles
Online AccessGet full text

Cover

Abstract Pre‐eclampsia is a hypertensive disease of pregnancy characterized by new‐onset hypertension, with either proteinuria and/or organ dysfunction. Pre‐eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in pre‐eclampsia is centered around abnormal placentation, inadequate spiral‐artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of pre‐eclampsia. ER stress, resulting in impaired autophagy and placental release of aggregated proteins, may also confer systemic stress to maternal organs in pre‐eclampsia. Extracellular vesicles (EVs), lipid‐bilayer enclosed structures containing macromolecules including proteins, miRNA, and other important nucleotides, have been suggested to play an important role in this maternal‐fetal communication. Circulating EVs are present in greater quantity in the plasma of pre‐eclampsia subjects compared to normal pregnancy, and the placental derived EVs have been shown to have altered protein and RNA cargo. In this review, we will focus on EVs and their role in pre‐eclampsia, specifically their role in immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
AbstractList Pre‐eclampsia is a hypertensive disease of pregnancy characterized by new‐onset hypertension, with either proteinuria and/or organ dysfunction. Pre‐eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in pre‐eclampsia is centered around abnormal placentation, inadequate spiral‐artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of pre‐eclampsia. ER stress, resulting in impaired autophagy and placental release of aggregated proteins, may also confer systemic stress to maternal organs in pre‐eclampsia. Extracellular vesicles (EVs), lipid‐bilayer enclosed structures containing macromolecules including proteins, miRNA, and other important nucleotides, have been suggested to play an important role in this maternal‐fetal communication. Circulating EVs are present in greater quantity in the plasma of pre‐eclampsia subjects compared to normal pregnancy, and the placental derived EVs have been shown to have altered protein and RNA cargo. In this review, we will focus on EVs and their role in pre‐eclampsia, specifically their role in immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
Pre-eclampsia is a hypertensive disease of pregnancy characterized by new-onset hypertension, with either proteinuria and/or organ dysfunction. Pre-eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in pre-eclampsia is centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of pre-eclampsia. ER stress, resulting in impaired autophagy and placental release of aggregated proteins, may also confer systemic stress to maternal organs in pre-eclampsia. Extracellular vesicles (EVs), lipid-bilayer enclosed structures containing macromolecules including proteins, miRNA, and other important nucleotides, have been suggested to play an important role in this maternal-fetal communication. Circulating EVs are present in greater quantity in the plasma of pre-eclampsia subjects compared to normal pregnancy, and the placental derived EVs have been shown to have altered protein and RNA cargo. In this review, we will focus on EVs and their role in pre-eclampsia, specifically their role in immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.Pre-eclampsia is a hypertensive disease of pregnancy characterized by new-onset hypertension, with either proteinuria and/or organ dysfunction. Pre-eclampsia is a leading cause of maternal morbidity and mortality; however, the underlying cellular and molecular mechanisms are not well understood. There is consensus that the underlying mechanism(s) resulting in pre-eclampsia is centered around abnormal placentation, inadequate spiral-artery remodeling, and deficiency in trophoblast invasion, resulting in impaired maternal blood flow to the placenta and a release of signals and/or inflammatory mediators into maternal circulation triggering the systemic manifestations of pre-eclampsia. ER stress, resulting in impaired autophagy and placental release of aggregated proteins, may also confer systemic stress to maternal organs in pre-eclampsia. Extracellular vesicles (EVs), lipid-bilayer enclosed structures containing macromolecules including proteins, miRNA, and other important nucleotides, have been suggested to play an important role in this maternal-fetal communication. Circulating EVs are present in greater quantity in the plasma of pre-eclampsia subjects compared to normal pregnancy, and the placental derived EVs have been shown to have altered protein and RNA cargo. In this review, we will focus on EVs and their role in pre-eclampsia, specifically their role in immune responses, inflammation, altered angiogenesis, and endothelial dysfunction.
Author Padbury, James
Cheng, Shi‐Bin
Schuster, Jessica
Sharma, Surendra
Author_xml – sequence: 1
  givenname: Jessica
  orcidid: 0000-0002-3488-556X
  surname: Schuster
  fullname: Schuster, Jessica
  email: Jschuster@wihri.org
  organization: Women and Infants Hospital of Rhode Island
– sequence: 2
  givenname: Shi‐Bin
  orcidid: 0000-0003-4911-6234
  surname: Cheng
  fullname: Cheng, Shi‐Bin
  organization: Women and Infants Hospital of Rhode Island
– sequence: 3
  givenname: James
  surname: Padbury
  fullname: Padbury, James
  organization: Women and Infants Hospital of Rhode Island
– sequence: 4
  givenname: Surendra
  orcidid: 0000-0002-4331-3467
  surname: Sharma
  fullname: Sharma, Surendra
  organization: Women and Infants Hospital of Rhode Island
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32619308$$D View this record in MEDLINE/PubMed
BookMark eNp1kLtOwzAUhi1URC8w8AKoEgsMaZ34JI7HquJSVAkGmC3HcSRXzgU7AbrxCDwjT4JL26UCLz46-v5fR98Q9aq6Ugidh3gS-jcVKz0JScToERqECcYBThnt-RlDElDAaR8NnVth7PeEnqA-iZKQEZwOEDwZIVXVCjNWH631szGdEXb8ppyWRrmxqPJxY9X355eSRpSN0-IUHRfCOHW2-0fo5fbmeX4fLB_vFvPZMpAQAw0YgIyhUDhLEhAiV5QWjERFkoexyHJWJAUApDKDLCaKEuK5IgYCmMkkpTEZoattb2Pr1065lpfabS4Ulao7xyOIcAgQM_Do5QG6qjtb-es8labAIKIb6mJHdVmpct5YXQq75nsfHphuAWlr56wquNStaHVdeTfa8BDzjXHujfNf4z5xfZDYl_7F7trftVHr_0E-e1hsEz_zA44u
CitedBy_id crossref_primary_10_3390_ijms232113115
crossref_primary_10_3390_ijms25105102
crossref_primary_10_3389_fcimb_2021_694298
crossref_primary_10_3390_ijerph17239046
crossref_primary_10_1016_j_bcp_2022_115192
crossref_primary_10_3390_biology14030240
crossref_primary_10_1016_j_smim_2024_101925
crossref_primary_10_1021_acssensors_3c00689
crossref_primary_10_1007_s10304_023_00534_1
crossref_primary_10_3389_fcvm_2023_1291642
crossref_primary_10_3390_jcm11206048
crossref_primary_10_1080_08820139_2025_2450234
crossref_primary_10_1093_biolre_ioae069
crossref_primary_10_1111_aji_13844
crossref_primary_10_1007_s43032_024_01591_y
crossref_primary_10_1080_21655979_2022_2040873
crossref_primary_10_1038_s41598_024_64057_w
crossref_primary_10_3390_ijms25031538
crossref_primary_10_1016_j_yexcr_2024_113979
crossref_primary_10_1007_s13577_023_00986_4
crossref_primary_10_1080_1744666X_2022_2074399
crossref_primary_10_1002_adtp_202300145
crossref_primary_10_3390_cells11091588
crossref_primary_10_3390_ijms22105402
crossref_primary_10_3390_jpm11100956
crossref_primary_10_1016_j_jri_2024_104417
crossref_primary_10_1161_HYPERTENSIONAHA_121_18916
crossref_primary_10_1111_aji_13928
crossref_primary_10_3390_antiox14010055
crossref_primary_10_3389_fphar_2022_1001652
crossref_primary_10_1080_10641955_2024_2445556
Cites_doi 10.1016/j.trsl.2016.02.012
10.1126/scitranslmed.3008808
10.1016/j.coi.2018.02.004
10.1038/srep44433
10.1161/HYPERTENSIONAHA.110.150078
10.4049/jimmunol.1203488
10.1210/jc.2017-00672
10.1182/blood.V84.1.143.143
10.1016/j.ajog.2016.04.041
10.3402/jev.v3.24641
10.1371/journal.pone.0098667
10.1161/HYPERTENSIONAHA.113.01494
10.1016/j.placenta.2013.04.013
10.1016/j.placenta.2018.04.013
10.1016/j.ceb.2014.05.004
10.3402/jev.v4.27066
10.1111/j.1365-2567.2012.03568.x
10.1007/s00428-008-0658-x
10.1016/0143-4004(91)90339-H
10.1016/j.placenta.2012.10.005
10.1038/cmi.2014.42
10.1111/j.1600-0897.2011.00995.x
10.1007/s00281-018-0680-2
10.1111/aji.12311
10.1155/2013/985606
10.3389/fphar.2016.00432
10.1111/j.1600-0897.2006.00435.x
10.4049/jimmunol.0803477
10.1016/j.placenta.2009.02.009
10.1371/journal.pone.0026313
10.1111/aji.12446
10.1542/peds.2011-3093
10.1016/j.jmb.2009.07.025
10.1056/NEJMoa055352
10.1016/j.semnephrol.2010.10.002
10.1371/journal.pone.0056754
10.1096/fj.13-239053
10.1161/HYPERTENSIONAHA.118.11706
10.1016/j.ajog.2008.01.013
10.1002/cld.409
10.1186/1479-5876-12-204
10.1038/s41598-020-62193-7
10.1095/biolreprod.114.121616
10.1016/j.placenta.2016.09.008
10.1016/j.abb.2018.09.023
10.1146/annurev-cellbio-101512-122326
10.1016/j.gene.2019.01.012
10.1016/j.placenta.2016.08.078
10.1161/CIRCULATIONAHA.113.003664
10.1080/15548627.2019.1707494
10.1016/j.cell.2010.01.028
10.4049/jimmunol.1301885
10.4049/jimmunol.178.9.5949
10.1007/s00281-016-0579-8
10.4161/mabs.27230
10.1016/j.placenta.2009.11.011
10.1038/s41598-019-47607-5
10.1016/j.ajpath.2018.07.021
10.1161/HYPERTENSIONAHA.119.12707
10.1161/HYPERTENSIONAHA.117.09321
10.1016/j.ajog.2015.07.001
10.1016/j.placenta.2016.12.016
10.1093/aje/155.3.203
10.1073/pnas.1304718110
10.1016/j.ajpath.2013.07.022
10.1152/ajpregu.00600.2011
10.3389/fendo.2017.00174
10.1371/journal.pone.0174514
10.1016/j.placenta.2004.11.007
10.1038/ncb1596
10.1161/HYPERTENSIONAHA.119.14081
10.1007/s11060-013-1084-8
10.1126/science.1136880
10.1152/ajpheart.00298.2003
10.1136/bmj.f6564
10.1530/REP-19-0147
10.3390/ijms20122972
10.1371/journal.pone.0079636
10.1093/humrep/dew004
10.4161/auto.26558
10.1002/path.4678
10.1016/j.jsgi.2004.03.003
10.1177/1933719111404608
10.1152/ajpregu.00355.2017
10.1016/j.ejogrb.2013.05.005
10.1186/s40478-017-0467-z
10.1210/er.2017-00229
10.1111/j.1600-0897.2010.00822.x
10.1093/molehr/gaw027
10.1038/s41598-017-07017-x
10.2353/ajpath.2010.100475
ContentType Journal Article
Copyright 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Copyright © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Copyright_xml – notice: 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
– notice: 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
– notice: Copyright © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7U9
H94
K9.
7X8
DOI 10.1111/aji.13297
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
ProQuest Health & Medical Complete (Alumni)
Immunology Abstracts
Virology and AIDS Abstracts
MEDLINE - Academic
DatabaseTitleList CrossRef
MEDLINE - Academic
AIDS and Cancer Research Abstracts

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Anatomy & Physiology
EISSN 1600-0897
EndPage n/a
ExternalDocumentID 32619308
10_1111_aji_13297
AJI13297
Genre article
Journal Article
Review
Research Support, N.I.H., Extramural
GrantInformation_xml – fundername: National Institute of General Medical Sciences
  funderid: P20 GM121298; P30 GM114750
– fundername: NIGMS NIH HHS
  grantid: P30 GM114750
– fundername: NIGMS NIH HHS
  grantid: P20 GM121298
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
1OB
1OC
23M
31~
33P
36B
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5RE
5VS
66C
6J9
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHHS
AAHQN
AAIPD
AAKAS
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAXRX
AAYCA
AAZKR
ABCQN
ABCUV
ABDBF
ABEML
ABJNI
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACGOF
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACUHS
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZCM
ADZMN
ADZOD
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFEBI
AFFNX
AFFPM
AFGKR
AFPWT
AFWVQ
AFZJQ
AHBTC
AHMBA
AI.
AIACR
AIAGR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
AOETA
ATUGU
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CAG
COF
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
EAD
EAP
EAS
EBC
EBD
EBS
EBX
EJD
EMB
EMK
EMOBN
ESX
EX3
F00
F01
F04
F5P
FEDTE
FUBAC
FZ0
G-S
G.N
GODZA
H.X
HF~
HGLYW
HVGLF
HZI
HZ~
IHE
IX1
J0M
K48
KBYEO
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
R.K
RJQFR
ROL
RX1
SAMSI
SUPJJ
SV3
TEORI
TUS
UB1
V8K
VH1
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WOHZO
WOW
WQJ
WRC
WVDHM
WXI
WXSBR
XG1
YFH
YUY
ZZTAW
~IA
~WT
AAYXX
AEYWJ
AGHNM
AGQPQ
AGYGG
CITATION
AAMMB
AEFGJ
AGXDD
AIDQK
AIDYY
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7U9
H94
K9.
7X8
ID FETCH-LOGICAL-c4547-944c54fe0b664aade77f932f6d15abd9f6f4448cb4b53e733b66f543409c68753
IEDL.DBID DR2
ISSN 1046-7408
1600-0897
IngestDate Fri Jul 11 11:10:01 EDT 2025
Fri Jul 25 10:41:17 EDT 2025
Mon Jul 21 05:58:34 EDT 2025
Tue Jul 01 01:30:25 EDT 2025
Thu Apr 24 23:05:12 EDT 2025
Wed Jan 22 16:31:36 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords placenta
pre-eclampsia
extracellular vesicles
Language English
License 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c4547-944c54fe0b664aade77f932f6d15abd9f6f4448cb4b53e733b66f543409c68753
Notes Funding information
This work was supported in part by the NIH P20 GM121298 and P30 GM114750 grants.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-4331-3467
0000-0002-3488-556X
0000-0003-4911-6234
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/7779690
PMID 32619308
PQID 2488494274
PQPubID 1036380
PageCount 9
ParticipantIDs proquest_miscellaneous_2420144594
proquest_journals_2488494274
pubmed_primary_32619308
crossref_citationtrail_10_1111_aji_13297
crossref_primary_10_1111_aji_13297
wiley_primary_10_1111_aji_13297_AJI13297
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate February 2021
PublicationDateYYYYMMDD 2021-02-01
PublicationDate_xml – month: 02
  year: 2021
  text: February 2021
PublicationDecade 2020
PublicationPlace Denmark
PublicationPlace_xml – name: Denmark
– name: New Haven
PublicationTitle American journal of reproductive immunology (1989)
PublicationTitleAlternate Am J Reprod Immunol
PublicationYear 2021
Publisher Wiley Subscription Services, Inc
Publisher_xml – name: Wiley Subscription Services, Inc
References 2010; 56
2017; 5
2004; 286
2017; 7
2017; 8
1991; 12
2013; 62
2002; 155
2019; 15
2013; 122
2016; 31
2016; 75
2018; 41
2009; 392
2018; 40
2010; 140
2014; 29
2020; 10
2014; 28
2013; 8
2014; 130
2016; 38
2011; 18
2012; 129
2010; 63
2013; 9
2007; 178
2018; 39
2014; 4
2014; 3
2017; 70
2019; 20
2013; 2013
2015; 213
2006; 27
2007; 9
2011; 66
2019; 158
2013; 113
2016; 238
2018; 659
2013; 110
2018; 72
2014; 9
2012; 136
2013; 191
2008; 199
2014; 6
2016; 47
2014; 12
2014; 11
2016; 46
2013; 190
2018; 188
2010; 31
2019; 9
2014; 91
2019; 73
2015; 4
2006; 56
2013; 347
2011; 31
2018; 66
2011; 6
2013; 183
2012; 303
2012; 33
1994; 84
2006; 355
2004; 11
2017; 50
2016; 7
2009; 30
2007; 315
2020; 75
2018; 314
2013; 34
2017; 12
2010; 177
2009; 183
2018; 51
2016; 215
2013; 170
2014; 30
2008; 453
2014; 72
2017; 102
2019; 692
2016; 172
2016; 22
e_1_2_8_28_1
e_1_2_8_24_1
e_1_2_8_47_1
e_1_2_8_26_1
e_1_2_8_68_1
e_1_2_8_3_1
e_1_2_8_81_1
e_1_2_8_7_1
e_1_2_8_9_1
e_1_2_8_20_1
e_1_2_8_43_1
e_1_2_8_66_1
e_1_2_8_89_1
e_1_2_8_22_1
e_1_2_8_45_1
e_1_2_8_64_1
e_1_2_8_87_1
e_1_2_8_62_1
e_1_2_8_85_1
e_1_2_8_41_1
e_1_2_8_60_1
e_1_2_8_83_1
e_1_2_8_17_1
e_1_2_8_19_1
e_1_2_8_13_1
e_1_2_8_36_1
e_1_2_8_59_1
e_1_2_8_15_1
e_1_2_8_38_1
e_1_2_8_57_1
American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy (e_1_2_8_5_1) 2013; 122
e_1_2_8_70_1
e_1_2_8_91_1
e_1_2_8_32_1
e_1_2_8_55_1
e_1_2_8_78_1
e_1_2_8_11_1
e_1_2_8_34_1
e_1_2_8_53_1
e_1_2_8_76_1
e_1_2_8_51_1
e_1_2_8_74_1
e_1_2_8_30_1
e_1_2_8_72_1
e_1_2_8_93_1
e_1_2_8_29_1
e_1_2_8_25_1
e_1_2_8_46_1
e_1_2_8_27_1
e_1_2_8_48_1
e_1_2_8_69_1
e_1_2_8_2_1
e_1_2_8_80_1
e_1_2_8_4_1
e_1_2_8_6_1
e_1_2_8_8_1
e_1_2_8_21_1
e_1_2_8_42_1
e_1_2_8_67_1
e_1_2_8_88_1
e_1_2_8_23_1
e_1_2_8_44_1
e_1_2_8_65_1
e_1_2_8_86_1
e_1_2_8_63_1
e_1_2_8_84_1
e_1_2_8_40_1
e_1_2_8_61_1
e_1_2_8_82_1
e_1_2_8_18_1
e_1_2_8_39_1
e_1_2_8_14_1
e_1_2_8_35_1
e_1_2_8_16_1
e_1_2_8_37_1
e_1_2_8_58_1
e_1_2_8_79_1
e_1_2_8_92_1
e_1_2_8_94_1
e_1_2_8_90_1
Shen L (e_1_2_8_49_1) 2018; 41
e_1_2_8_10_1
e_1_2_8_31_1
e_1_2_8_56_1
e_1_2_8_77_1
e_1_2_8_12_1
e_1_2_8_33_1
e_1_2_8_54_1
e_1_2_8_75_1
e_1_2_8_52_1
e_1_2_8_73_1
e_1_2_8_50_1
e_1_2_8_71_1
References_xml – volume: 347
  year: 2013
  article-title: Pre‐eclampsia rates in the United States, 1980–2010: age‐period‐cohort analysis
  publication-title: BMJ
– volume: 47
  start-page: 86
  year: 2016
  end-page: 95
  article-title: Isolation of human trophoblastic extracellular vesicles and characterization of their cargo and antiviral activity
  publication-title: Placenta
– volume: 5
  issue: 1
  year: 2017
  article-title: Are exosomes the vehicle for protein aggregate propagation in neurodegenerative diseases?
  publication-title: Acta Neuropathol Commun
– volume: 659
  start-page: 13
  year: 2018
  end-page: 21
  article-title: Role of mesenchymal stem cells exosomes derived microRNAs; miR‐136, miR‐494 and miR‐495 in pre‐eclampsia diagnosis and evaluation
  publication-title: Arch Biochem Biophys
– volume: 46
  start-page: 18
  year: 2016
  end-page: 25
  article-title: Placental exosomes and pre‐eclampsia: Maternal circulating levels in normal pregnancies and early and late onset pre‐eclamptic pregnancies
  publication-title: Placenta
– volume: 314
  start-page: R499
  issue: 4
  year: 2018
  end-page: R508
  article-title: Animal models of preeclampsia: translational failings and why
  publication-title: Am J Physiol Regul Integr Comp Physiol
– volume: 73
  start-page: 1112
  issue: 5
  year: 2019
  end-page: 1119
  article-title: Placental syncytiotrophoblast‐derived extracellular vesicles carry active NEP (neprilysin) and are increased in preeclampsia
  publication-title: Hypertension
– volume: 8
  year: 2017
  article-title: Micro‐ and nano‐vesicles from first trimester human placentae carry Flt‐1 and levels are increased in severe preeclampsia
  publication-title: Front Endocrinol (Lausanne)
– volume: 122
  start-page: 1122
  issue: 5
  year: 2013
  end-page: 1131
  article-title: Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy
  publication-title: Obstet Gynecol
– volume: 692
  start-page: 138
  year: 2019
  end-page: 144
  article-title: Circulating exosomal and Argonaute‐bound microRNAs in preeclampsia
  publication-title: Gene
– volume: 33
  start-page: 982
  issue: 12
  year: 2012
  end-page: 990
  article-title: Immunomodulatory molecules are released from the first trimester and term placenta via exosomes
  publication-title: Placenta
– volume: 10
  issue: 1
  year: 2020
  article-title: Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
  publication-title: Sci Rep
– volume: 2013
  year: 2013
  article-title: Contemporary clinical management of the cerebral complications of preeclampsia
  publication-title: Obstet Gynecol Int
– volume: 215
  start-page: 464.e1
  issue: 4
  year: 2016
  end-page: 464.e7
  article-title: Urinary congophilia in women with hypertensive disorders of pregnancy and preexisting proteinuria or hypertension
  publication-title: Am J Obstet Gynecol
– volume: 91
  issue: 5
  year: 2014
  article-title: Human exosomal placenta‐associated miR‐517a‐3p modulates the expression of PRKG1 mRNA in Jurkat cells
  publication-title: Biol Reprod
– volume: 453
  start-page: 387
  issue: 4
  year: 2008
  end-page: 400
  article-title: Placental protein 13 (galectin‐13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre‐eclampsia and HELLP syndrome
  publication-title: Virchows Arch
– volume: 190
  start-page: 3639
  issue: 7
  year: 2013
  end-page: 3647
  article-title: NKG2D blockade inhibits poly(I:C)‐triggered fetal loss in wild type but not in IL‐10‐/‐ mice
  publication-title: J Immunol
– volume: 9
  issue: 6
  year: 2014
  article-title: A gestational profile of placental exosomes in maternal plasma and their effects on endothelial cell migration
  publication-title: PLoS One
– volume: 34
  start-page: 513
  issue: 7
  year: 2013
  end-page: 517
  article-title: Transthyretin and the human placenta
  publication-title: Placenta
– volume: 8
  issue: 11
  year: 2013
  article-title: Hypoxia‐induced changes in the bioactivity of cytotrophoblast‐derived exosomes
  publication-title: PLoS One
– volume: 51
  start-page: 55
  year: 2018
  end-page: 61
  article-title: NKG2D and its ligands in cancer
  publication-title: Curr Opin Immunol
– volume: 50
  start-page: 25
  year: 2017
  end-page: 31
  article-title: Endogenous and exogenous miR‐520c‐3p modulates CD44‐mediated extravillous trophoblast invasion
  publication-title: Placenta
– volume: 31
  start-page: 106
  issue: 2
  year: 2010
  end-page: 112
  article-title: Feto‐maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes
  publication-title: Placenta
– volume: 6
  issue: 10
  year: 2011
  article-title: Syncytiotrophoblast microvesicles released from pre‐eclampsia placentae exhibit increased tissue factor activity
  publication-title: PLoS One
– volume: 177
  start-page: 2387
  issue: 5
  year: 2010
  end-page: 2398
  article-title: Sera from preeclampsia patients elicit symptoms of human disease in mice and provide a basis for an in vitro predictive assay
  publication-title: Am J Pathol
– volume: 6
  start-page: 86
  issue: 1
  year: 2014
  end-page: 94
  article-title: A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer
  publication-title: MAbs
– volume: 9
  start-page: 654
  issue: 6
  year: 2007
  end-page: 659
  article-title: Exosome‐mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
  publication-title: Nat Cell Biol
– volume: 15
  start-page: 1
  year: 2019
  end-page: 15
  article-title: Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
  publication-title: Autophagy
– volume: 12
  year: 2014
  article-title: Placenta‐derived exosomes continuously increase in maternal circulation over the first trimester of pregnancy
  publication-title: J Transl Med
– volume: 72
  start-page: 1381
  issue: 6
  year: 2018
  end-page: 1390
  article-title: Exosomes from women with preeclampsia induced vascular dysfunction by delivering sFlt (soluble Fms‐like tyrosine kinase)‐1 and sEng (soluble endoglin) to endothelial cells
  publication-title: Hypertension
– volume: 12
  issue: 3
  year: 2017
  article-title: Oxygen tension regulates the miRNA profile and bioactivity of exosomes released from extravillous trophoblast cells ‐ liquid biopsies for monitoring complications of pregnancy
  publication-title: PLoS One
– volume: 110
  start-page: 12048
  issue: 29
  year: 2013
  end-page: 12053
  article-title: Human placental trophoblasts confer viral resistance to recipient cells
  publication-title: Proc Natl Acad Sci U S A
– volume: 30
  start-page: 473
  issue: 6
  year: 2009
  end-page: 482
  article-title: Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
  publication-title: Placenta
– volume: 31
  start-page: 687
  issue: 4
  year: 2016
  end-page: 699
  article-title: Proteomic characterization of macro‐, micro‐ and nano‐extracellular vesicles derived from the same first trimester placenta: relevance for feto‐maternal communication
  publication-title: Hum Reprod
– volume: 70
  start-page: 372
  issue: 2
  year: 2017
  end-page: 381
  article-title: Placental vesicles carry active endothelial nitric oxide synthase and their activity is reduced in preeclampsia
  publication-title: Hypertension
– volume: 140
  start-page: 313
  issue: 3
  year: 2010
  end-page: 326
  article-title: Methods in mammalian autophagy research
  publication-title: Cell
– volume: 7
  year: 2016
  article-title: Feto‐maternal trafficking of exosomes in murine pregnancy models
  publication-title: Front Pharmacol
– volume: 72
  start-page: 440
  issue: 5
  year: 2014
  end-page: 457
  article-title: Placenta‐derived exosomes and syncytiotrophoblast microparticles and their role in human reproduction: immune modulation for pregnancy success
  publication-title: Am J Reprod Immunol
– volume: 63
  start-page: 520
  issue: 6
  year: 2010
  end-page: 533
  article-title: The role of placental exosomes in reproduction
  publication-title: Am J Reprod Immunol
– volume: 20
  issue: 12
  year: 2019
  article-title: The prediction of gestational hypertension, preeclampsia and fetal growth restriction via the first trimester screening of plasma exosomal C19MC microRNAs
  publication-title: Int J Mol Sci
– volume: 75
  start-page: 762
  issue: 3
  year: 2020
  end-page: 771
  article-title: Unique microRNA signals in plasma exosomes from pregnancies complicated by preeclampsia
  publication-title: Hypertension
– volume: 11
  start-page: 548
  issue: 6
  year: 2014
  end-page: 563
  article-title: Extracellular vesicles and reproduction‐promotion of successful pregnancy
  publication-title: Cell Mol Immunol
– volume: 191
  start-page: 5515
  issue: 11
  year: 2013
  end-page: 5523
  article-title: Exosomes secreted by human placenta carry functional Fas ligand and TRAIL molecules and convey apoptosis in activated immune cells, suggesting exosome‐mediated immune privilege of the fetus
  publication-title: J Immunol
– volume: 9
  start-page: 2173
  issue: 12
  year: 2013
  end-page: 2174
  article-title: Autophagy as a mechanism of antiviral defense at the maternal‐fetal interface
  publication-title: Autophagy
– volume: 6
  issue: 245
  year: 2014
  article-title: Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia
  publication-title: Sci Transl Med
– volume: 238
  start-page: 550
  issue: 4
  year: 2016
  end-page: 561
  article-title: Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6beta: implications for the pathophysiology of human pregnancy complications
  publication-title: J Pathol
– volume: 3
  issue: 1
  year: 2014
  article-title: Routes and mechanisms of extracellular vesicle uptake
  publication-title: J Extracell Vesicles
– volume: 113
  start-page: 1
  issue: 1
  year: 2013
  end-page: 11
  article-title: Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus‐like vesicles, and apoptotic bodies
  publication-title: J Neurooncol
– volume: 28
  start-page: 3703
  issue: 8
  year: 2014
  end-page: 3719
  article-title: Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia
  publication-title: FASEB J
– volume: 303
  start-page: R86
  issue: 1
  year: 2012
  end-page: 93
  article-title: eNOS knockout mouse as a model of fetal growth restriction with an impaired uterine artery function and placental transport phenotype
  publication-title: Am J Physiol Regul Integr Comp Physiol
– volume: 18
  start-page: 1085
  issue: 11
  year: 2011
  end-page: 1091
  article-title: Reduced expression of both syncytin 1 and syncytin 2 correlates with severity of preeclampsia
  publication-title: Reprod Sci
– volume: 158
  start-page: R189
  issue: 5
  year: 2019
  end-page: R196
  article-title: Effects of extracellular vesicles on placentation and pregnancy disorders
  publication-title: Reproduction
– volume: 315
  start-page: 1398
  issue: 5817
  year: 2007
  end-page: 1401
  article-title: Autophagy‐dependent viral recognition by plasmacytoid dendritic cells
  publication-title: Science
– volume: 30
  start-page: 255
  year: 2014
  end-page: 289
  article-title: Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
  publication-title: Annu Rev Cell Dev Biol
– volume: 199
  start-page: 122.e1
  issue: 2
  year: 2008
  end-page: 122.e11
  article-title: First‐trimester maternal serum PP13 in the risk assessment for preeclampsia
  publication-title: Am J Obstet Gynecol
– volume: 27
  start-page: 56
  issue: 1
  year: 2006
  end-page: 61
  article-title: Excess syncytiotrophoblast microparticle shedding is a feature of early‐onset pre‐eclampsia, but not normotensive intrauterine growth restriction
  publication-title: Placenta
– volume: 286
  start-page: H1389
  issue: 4
  year: 2004
  end-page: 1393
  article-title: Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk
  publication-title: Am J Physiol Heart Circ Physiol
– volume: 22
  start-page: 465
  issue: 7
  year: 2016
  end-page: 474
  article-title: Antiphospholipid antibody‐induced miR‐146a‐3p drives trophoblast interleukin‐8 secretion through activation of Toll‐like receptor 8
  publication-title: Mol Hum Reprod
– volume: 66
  start-page: 259
  issue: 4
  year: 2011
  end-page: 269
  article-title: Human trophoblast‐derived exosomal fibronectin induces pro‐inflammatory IL‐1beta production by macrophages
  publication-title: Am J Reprod Immunol
– volume: 170
  start-page: 1
  issue: 1
  year: 2013
  end-page: 7
  article-title: Global and regional estimates of preeclampsia and eclampsia: a systematic review
  publication-title: Eur J Obstet Gynecol Reprod Biol
– volume: 102
  start-page: 3182
  issue: 9
  year: 2017
  end-page: 3194
  article-title: Placental exosomes as early biomarker of preeclampsia: potential role of exosomal microRNAs across gestation
  publication-title: J Clin Endocrinol Metab
– volume: 75
  start-page: 372
  issue: 3
  year: 2016
  end-page: 381
  article-title: Understanding pre‐eclampsia using Alzheimer's etiology: an intriguing viewpoint
  publication-title: Am J Reprod Immunol
– volume: 129
  start-page: e1552
  issue: 6
  year: 2012
  end-page: e1561
  article-title: Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review
  publication-title: Pediatrics
– volume: 172
  start-page: 61
  year: 2016
  end-page: 72
  article-title: MicroRNA‐141 is upregulated in preeclamptic placentae and regulates trophoblast invasion and intercellular communication
  publication-title: Transl Res
– volume: 392
  start-page: 301
  issue: 2
  year: 2009
  end-page: 318
  article-title: Syncytin‐2 plays an important role in the fusion of human trophoblast cells
  publication-title: J Mol Biol
– volume: 178
  start-page: 5949
  issue: 9
  year: 2007
  end-page: 5956
  article-title: Systemic inflammatory priming in normal pregnancy and preeclampsia: the role of circulating syncytiotrophoblast microparticles
  publication-title: J Immunol
– volume: 66
  start-page: 17
  year: 2018
  end-page: 25
  article-title: Reduced placental protein 13 (PP13) in placental derived syncytiotrophoblast extracellular vesicles in preeclampsia ‐ a novel tool to study the impaired cargo transmission of the placenta to the maternal organs
  publication-title: Placenta
– volume: 7
  issue: 1
  year: 2017
  article-title: Aggregated transthyretin is specifically packaged into placental nano‐vesicles in preeclampsia
  publication-title: Sci Rep
– volume: 130
  start-page: 703
  issue: 8
  year: 2014
  end-page: 714
  article-title: Cardiovascular implications in preeclampsia: an overview
  publication-title: Circulation
– volume: 183
  start-page: 1425
  issue: 5
  year: 2013
  end-page: 1436
  article-title: Transthyretin is dysregulated in preeclampsia, and its native form prevents the onset of disease in a preclinical mouse model
  publication-title: Am J Pathol
– volume: 38
  start-page: 699
  issue: 6
  year: 2016
  end-page: 708
  article-title: Preeclampsia and health risks later in life: an immunological link
  publication-title: Semin Immunopathol
– volume: 8
  issue: 2
  year: 2013
  article-title: Characterisation of syncytiotrophoblast vesicles in normal pregnancy and pre‐eclampsia: expression of Flt‐1 and endoglin
  publication-title: PLoS One
– volume: 183
  start-page: 340
  issue: 1
  year: 2009
  end-page: 351
  article-title: Human placenta expresses and secretes NKG2D ligands via exosomes that down‐modulate the cognate receptor expression: evidence for immunosuppressive function
  publication-title: J Immunol
– volume: 12
  start-page: 301
  issue: 4
  year: 1991
  end-page: 308
  article-title: Current topic: pre‐eclampsia and the placenta
  publication-title: Placenta
– volume: 7
  year: 2017
  article-title: White matter repair after extracellular vesicles administration in an experimental animal model of subcortical stroke
  publication-title: Sci Rep
– volume: 31
  start-page: 4
  issue: 1
  year: 2011
  end-page: 14
  article-title: The kidney in normal pregnancy and preeclampsia
  publication-title: Semin Nephrol
– volume: 56
  start-page: 345
  issue: 5–6
  year: 2006
  end-page: 355
  article-title: Specific isolation of placenta‐derived exosomes from the circulation of pregnant women and their immunoregulatory consequences
  publication-title: Am J Reprod Immunol
– volume: 4
  year: 2015
  article-title: Biological properties of extracellular vesicles and their physiological functions
  publication-title: J Extracell Vesicles
– volume: 84
  start-page: 143
  issue: 1
  year: 1994
  end-page: 150
  article-title: Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation
  publication-title: Blood
– volume: 188
  start-page: 2474
  issue: 11
  year: 2018
  end-page: 2486
  article-title: Trophoblast‐specific conditional Atg7 knockout mice develop gestational hypertension
  publication-title: Am J Pathol
– volume: 355
  start-page: 992
  issue: 10
  year: 2006
  end-page: 1005
  article-title: Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
  publication-title: N Engl J Med
– volume: 213
  start-page: S173
  issue: 4 Suppl
  year: 2015
  end-page: 181
  article-title: Placental exosomes in normal and complicated pregnancy
  publication-title: Am J Obstet Gynecol
– volume: 29
  start-page: 116
  year: 2014
  end-page: 125
  article-title: Biogenesis and secretion of exosomes
  publication-title: Curr Opin Cell Biol
– volume: 40
  start-page: 425
  issue: 5
  year: 2018
  end-page: 437
  article-title: Extracellular vesicles and their immunomodulatory functions in pregnancy
  publication-title: Semin Immunopathol
– volume: 62
  start-page: 893
  issue: 5
  year: 2013
  end-page: 898
  article-title: Microvesicles of women with gestational hypertension and preeclampsia affect human trophoblast fate and endothelial function
  publication-title: Hypertension
– volume: 136
  start-page: 184
  issue: 2
  year: 2012
  end-page: 191
  article-title: Immune cell activation by trophoblast‐derived microvesicles is mediated by syncytin 1
  publication-title: Immunology
– volume: 9
  issue: 1
  year: 2019
  article-title: Endoplasmic reticulum stress disrupts lysosomal homeostasis and induces blockade of autophagic flux in human trophoblasts
  publication-title: Sci Rep
– volume: 56
  start-page: 166
  issue: 1
  year: 2010
  end-page: 171
  article-title: Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort
  publication-title: Hypertension
– volume: 155
  start-page: 203
  issue: 3
  year: 2002
  end-page: 209
  article-title: Impact of preeclampsia and gestational hypertension on birth weight by gestational age
  publication-title: Am J Epidemiol
– volume: 41
  start-page: 1731
  issue: 3
  year: 2018
  end-page: 1739
  article-title: Placentaassociated serum exosomal miR155 derived from patients with preeclampsia inhibits eNOS expression in human umbilical vein endothelial cells
  publication-title: Int J Mol Med
– volume: 4
  start-page: 69
  issue: 3
  year: 2014
  end-page: 73
  article-title: Preeclampsia‐induced liver dysfunction, HELLP syndrome, and acute fatty liver of pregnancy
  publication-title: Clin Liver Dis (Hoboken)
– volume: 11
  start-page: 342
  issue: 6
  year: 2004
  end-page: 352
  article-title: Placental oxidative stress: from miscarriage to preeclampsia
  publication-title: J Soc Gynecol Investig
– volume: 39
  start-page: 292
  issue: 3
  year: 2018
  end-page: 332
  article-title: Extracellular vesicles in human reproduction in health and disease
  publication-title: Endocr Rev
– ident: e_1_2_8_44_1
  doi: 10.1016/j.trsl.2016.02.012
– ident: e_1_2_8_74_1
  doi: 10.1126/scitranslmed.3008808
– ident: e_1_2_8_37_1
  doi: 10.1016/j.coi.2018.02.004
– ident: e_1_2_8_89_1
  doi: 10.1038/srep44433
– ident: e_1_2_8_7_1
  doi: 10.1161/HYPERTENSIONAHA.110.150078
– ident: e_1_2_8_38_1
  doi: 10.4049/jimmunol.1203488
– ident: e_1_2_8_57_1
  doi: 10.1210/jc.2017-00672
– ident: e_1_2_8_69_1
  doi: 10.1182/blood.V84.1.143.143
– ident: e_1_2_8_75_1
  doi: 10.1016/j.ajog.2016.04.041
– ident: e_1_2_8_22_1
  doi: 10.3402/jev.v3.24641
– ident: e_1_2_8_31_1
  doi: 10.1371/journal.pone.0098667
– ident: e_1_2_8_60_1
  doi: 10.1161/HYPERTENSIONAHA.113.01494
– ident: e_1_2_8_81_1
  doi: 10.1016/j.placenta.2013.04.013
– ident: e_1_2_8_63_1
  doi: 10.1016/j.placenta.2018.04.013
– ident: e_1_2_8_23_1
  doi: 10.1016/j.ceb.2014.05.004
– ident: e_1_2_8_21_1
  doi: 10.3402/jev.v4.27066
– ident: e_1_2_8_52_1
  doi: 10.1111/j.1365-2567.2012.03568.x
– ident: e_1_2_8_62_1
  doi: 10.1007/s00428-008-0658-x
– ident: e_1_2_8_14_1
  doi: 10.1016/0143-4004(91)90339-H
– ident: e_1_2_8_39_1
  doi: 10.1016/j.placenta.2012.10.005
– ident: e_1_2_8_26_1
  doi: 10.1038/cmi.2014.42
– ident: e_1_2_8_45_1
  doi: 10.1111/j.1600-0897.2011.00995.x
– ident: e_1_2_8_53_1
  doi: 10.1007/s00281-018-0680-2
– ident: e_1_2_8_28_1
  doi: 10.1111/aji.12311
– ident: e_1_2_8_12_1
  doi: 10.1155/2013/985606
– ident: e_1_2_8_93_1
  doi: 10.3389/fphar.2016.00432
– ident: e_1_2_8_35_1
  doi: 10.1111/j.1600-0897.2006.00435.x
– ident: e_1_2_8_36_1
  doi: 10.4049/jimmunol.0803477
– ident: e_1_2_8_17_1
  doi: 10.1016/j.placenta.2009.02.009
– volume: 41
  start-page: 1731
  issue: 3
  year: 2018
  ident: e_1_2_8_49_1
  article-title: Placentaassociated serum exosomal miR155 derived from patients with preeclampsia inhibits eNOS expression in human umbilical vein endothelial cells
  publication-title: Int J Mol Med
– ident: e_1_2_8_70_1
  doi: 10.1371/journal.pone.0026313
– ident: e_1_2_8_82_1
  doi: 10.1111/aji.12446
– ident: e_1_2_8_8_1
  doi: 10.1542/peds.2011-3093
– ident: e_1_2_8_64_1
  doi: 10.1016/j.jmb.2009.07.025
– ident: e_1_2_8_67_1
  doi: 10.1056/NEJMoa055352
– ident: e_1_2_8_11_1
  doi: 10.1016/j.semnephrol.2010.10.002
– ident: e_1_2_8_18_1
  doi: 10.1371/journal.pone.0056754
– ident: e_1_2_8_65_1
  doi: 10.1096/fj.13-239053
– ident: e_1_2_8_94_1
  doi: 10.1161/HYPERTENSIONAHA.118.11706
– ident: e_1_2_8_61_1
  doi: 10.1016/j.ajog.2008.01.013
– ident: e_1_2_8_10_1
  doi: 10.1002/cld.409
– ident: e_1_2_8_29_1
  doi: 10.1186/1479-5876-12-204
– ident: e_1_2_8_56_1
  doi: 10.1038/s41598-020-62193-7
– ident: e_1_2_8_43_1
  doi: 10.1095/biolreprod.114.121616
– ident: e_1_2_8_27_1
  doi: 10.1016/j.placenta.2016.09.008
– ident: e_1_2_8_86_1
  doi: 10.1016/j.abb.2018.09.023
– ident: e_1_2_8_20_1
  doi: 10.1146/annurev-cellbio-101512-122326
– ident: e_1_2_8_85_1
  doi: 10.1016/j.gene.2019.01.012
– ident: e_1_2_8_58_1
  doi: 10.1016/j.placenta.2016.08.078
– ident: e_1_2_8_13_1
  doi: 10.1161/CIRCULATIONAHA.113.003664
– ident: e_1_2_8_76_1
  doi: 10.1080/15548627.2019.1707494
– ident: e_1_2_8_78_1
  doi: 10.1016/j.cell.2010.01.028
– ident: e_1_2_8_34_1
  doi: 10.4049/jimmunol.1301885
– ident: e_1_2_8_50_1
  doi: 10.4049/jimmunol.178.9.5949
– ident: e_1_2_8_54_1
  doi: 10.1007/s00281-016-0579-8
– ident: e_1_2_8_59_1
  doi: 10.4161/mabs.27230
– ident: e_1_2_8_51_1
  doi: 10.1016/j.placenta.2009.11.011
– ident: e_1_2_8_77_1
  doi: 10.1038/s41598-019-47607-5
– ident: e_1_2_8_92_1
  doi: 10.1016/j.ajpath.2018.07.021
– ident: e_1_2_8_9_1
  doi: 10.1161/HYPERTENSIONAHA.119.12707
– ident: e_1_2_8_48_1
  doi: 10.1161/HYPERTENSIONAHA.117.09321
– ident: e_1_2_8_19_1
  doi: 10.1016/j.ajog.2015.07.001
– ident: e_1_2_8_47_1
  doi: 10.1016/j.placenta.2016.12.016
– ident: e_1_2_8_2_1
  doi: 10.1093/aje/155.3.203
– ident: e_1_2_8_41_1
  doi: 10.1073/pnas.1304718110
– ident: e_1_2_8_73_1
  doi: 10.1016/j.ajpath.2013.07.022
– ident: e_1_2_8_91_1
  doi: 10.1152/ajpregu.00600.2011
– ident: e_1_2_8_71_1
  doi: 10.3389/fendo.2017.00174
– ident: e_1_2_8_40_1
  doi: 10.1371/journal.pone.0174514
– ident: e_1_2_8_55_1
  doi: 10.1016/j.placenta.2004.11.007
– ident: e_1_2_8_84_1
  doi: 10.1038/ncb1596
– ident: e_1_2_8_88_1
  doi: 10.1161/HYPERTENSIONAHA.119.14081
– ident: e_1_2_8_24_1
  doi: 10.1007/s11060-013-1084-8
– ident: e_1_2_8_79_1
  doi: 10.1126/science.1136880
– ident: e_1_2_8_6_1
  doi: 10.1152/ajpheart.00298.2003
– ident: e_1_2_8_4_1
  doi: 10.1136/bmj.f6564
– ident: e_1_2_8_15_1
  doi: 10.1530/REP-19-0147
– ident: e_1_2_8_87_1
  doi: 10.3390/ijms20122972
– ident: e_1_2_8_33_1
  doi: 10.1371/journal.pone.0079636
– ident: e_1_2_8_32_1
  doi: 10.1093/humrep/dew004
– ident: e_1_2_8_42_1
  doi: 10.4161/auto.26558
– ident: e_1_2_8_80_1
  doi: 10.1002/path.4678
– ident: e_1_2_8_16_1
  doi: 10.1016/j.jsgi.2004.03.003
– ident: e_1_2_8_66_1
  doi: 10.1177/1933719111404608
– ident: e_1_2_8_90_1
  doi: 10.1152/ajpregu.00355.2017
– volume: 122
  start-page: 1122
  issue: 5
  year: 2013
  ident: e_1_2_8_5_1
  article-title: Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy
  publication-title: Obstet Gynecol
– ident: e_1_2_8_3_1
  doi: 10.1016/j.ejogrb.2013.05.005
– ident: e_1_2_8_83_1
  doi: 10.1186/s40478-017-0467-z
– ident: e_1_2_8_25_1
  doi: 10.1210/er.2017-00229
– ident: e_1_2_8_30_1
  doi: 10.1111/j.1600-0897.2010.00822.x
– ident: e_1_2_8_46_1
  doi: 10.1093/molehr/gaw027
– ident: e_1_2_8_72_1
  doi: 10.1038/s41598-017-07017-x
– ident: e_1_2_8_68_1
  doi: 10.2353/ajpath.2010.100475
SSID ssj0008937
Score 2.4691727
SecondaryResourceType review_article
Snippet Pre‐eclampsia is a hypertensive disease of pregnancy characterized by new‐onset hypertension, with either proteinuria and/or organ dysfunction. Pre‐eclampsia...
Pre-eclampsia is a hypertensive disease of pregnancy characterized by new-onset hypertension, with either proteinuria and/or organ dysfunction. Pre-eclampsia...
SourceID proquest
pubmed
crossref
wiley
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage e13297
SubjectTerms Angiogenesis
Animals
Autophagy
Blood flow
Eclampsia
Extracellular vesicles
Extracellular Vesicles - metabolism
Female
Fetuses
Humans
Immune response
Immunity - immunology
Inflammation
Inflammation - immunology
Macromolecules
miRNA
Molecular modelling
Morbidity
Neovascularization, Pathologic
Nucleotides
Phagocytosis
Placenta
Placenta - metabolism
Pre-Eclampsia - immunology
Preeclampsia
Pregnancy
pre‐eclampsia
Proteinuria
Title Placental extracellular vesicles and pre‐eclampsia
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Faji.13297
https://www.ncbi.nlm.nih.gov/pubmed/32619308
https://www.proquest.com/docview/2488494274
https://www.proquest.com/docview/2420144594
Volume 85
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1fS9xAEB_kHqQvrZ62Pb1KKiK-5Eg2m80Fn46iqKCIVPBBCLubXThbc8f9EfTJj-Bn9JM4s_mjVgulb4FM2GRnZuc3k9nfAmwxGZs8YZEfCst8rkPup9JGPgZXFumQWZFTQf_4RByc86OL-GIBduu9MCU_RFNwI89w6zU5uFTTF04ur4Y9OiWddpJTrxYBorNn6iiKwyUTgfATHvQrViHq4mmefB2L3gDM13jVBZz9T3BZv2rZZ_KrN5-pnr77g8XxP79lCT5WQNQblJazDAumaMPKoMAk_PrW2_Zca6irubdh8bj6A78C_JTq7rSF0sNlfSKp8E-drN6NmboOO08WuTeemMf7B6PR3MbToVyF8_29nz8O_OrkBV8TwZefcq5jbk2ghOBS5iZJLAI9VFwYS5WnVliOeZ1WXMWRSaII5SxtUg1SLSgD-gytYlSYr-DpgBmLsNMkMuRG9FMVKESNJiWwElvegZ1aB5muaMnpdIzfWZ2e4ORkbnI6sNmIjksujveEurUis8odpxnDZYqnHDPwDnxvbqMj0STJwozmJMMou4xTlPlSGkAzSkR5ZhT08WWdGv8-fDY4OnQXa_8uug4fGHXKuF7wLrRmk7n5hlBnpjacTT8B_Q73Ww
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS-RAEC5cBdcX72M81rgs4kuGpNPpTGBfhkUZjxERBV8kdDrd4BWHORbWp_0J-xv3l2xV5_BYBfEtkAqddFd11Vep_grgG5OhziIWuL4wzOXK524sTeCic2WB8pkRGSX0u8eic84PLsKLMfhenYUp-CHqhBtZht2vycApIf3EyuX1VZPapEefYII6eltAdfpIHkWeuOAiEG7EvVbJK0R1PPWjz73RfyHm84jVupy9GbisXraoNLlpjoZpUz284HH86NfMwnQZizrtQnnmYEzn87DQzhGH3_1yth1bHWrT7vMw2S1_wi8AP6HUO52idHBn70vK_VMxq_NTD2yRnSPzzOn19d_ff7RCjesNruQinO_tnv3ouGXzBVcRx5cbc65CbrSXCsGlzHQUGYz1cO38UKZZbIThCO1UytMw0FEQoJyhc6perASBoCUYz-9zvQKO8pg2GHnqSPpci1aceikGjjqmeCU0vAE71SIkqmQmpwYZt0mFUHByEjs5Dfhai_YKOo7XhNarlUxKixwkDHcqHnME4Q3Yqm-jLdEkyVzfj0iGEcAMY5RZLjSgHiUgqBl4LXxZu45vD5-0D_btxer7RTfhc-ese5Qc7R8frsEUo8IZWxq-DuPD_khvYOQzTL9YBf8Hc5j7dg
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1ZS-RAEC48QHzxXh3P7LIs-5Ih6XQ6E3wa1EHdVWRZwQchdDrd4BWHOQR98if4G_0lVnUOdV1BfAukQiddVV1fVaq_BvjOZKiziAWuLwxzufK5G0sTuBhcWaB8ZkRGBf2DQ7F7zPdPwpMR2Kz2whT8EHXBjTzDrtfk4N3MvHByeX7WpFPSo1EY58JrkUlv_3nmjqJAXFARCDfiXqukFaI2nvrR18HoDcJ8DVhtxOlMw2n1rkWjyUVzOEib6u4fGsdPfswMTJVI1GkXpjMLIzqfg_l2jln41a3zw7G9obboPgcTB-Uv-HngR1R4pz2UDq7rPUmVf2pldW5037bYOTLPnG5PP94_aIX21u2fyQU47uz83dp1y6MXXEUMX27MuQq50V4qBJcy01FkEOmh5vxQpllshOGY2KmUp2GgoyBAOUO7VL1YCUqBvsBYfp3rJXCUx7RB3Kkj6XMtWnHqpQgbdUxoJTS8AT8rHSSq5CWn4zEukyo_wclJ7OQ04Fst2i3IOP4ntFopMin9sZ8wXKd4zDEFb8DX-jZ6Ek2SzPX1kGQYpZdhjDKLhQHUowSUaAZeC1_WqvH94ZP2_p69WP646AZMHG13kt97h79WYJJR14ztC1-FsUFvqNcQ9gzSdWveT57D-i4
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Placental+extracellular+vesicles+and+pre-eclampsia&rft.jtitle=American+journal+of+reproductive+immunology+%281989%29&rft.au=Schuster%2C+Jessica&rft.au=Cheng%2C+Shi-Bin&rft.au=Padbury%2C+James&rft.au=Sharma%2C+Surendra&rft.date=2021-02-01&rft.eissn=1600-0897&rft.volume=85&rft.issue=2&rft.spage=e13297&rft_id=info:doi/10.1111%2Faji.13297&rft_id=info%3Apmid%2F32619308&rft.externalDocID=32619308
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1046-7408&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1046-7408&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1046-7408&client=summon