Synthesis, Insecticidal Assay and Molecular Docking Study of Novel Neonicotinoids N-Oxide Analogues

• Published in: Chinese journal of chemistry Vol. 30; no. 2; pp. 357 - 361
• Main Author: Zhang, Wenwen Fan, Yefeng Yu, Tao Xu, Zhiping Xu, Xiaoyong Cheng, Jiagao Li, Zhong
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.02.2012; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Aphididae; Aphis craccivora; bioactivity; Chemistry; Chemistry, Multidisciplinary; computational chemical study; HRMS; N-oxide; N-氧化物; NPA atomic charges; Physical Sciences; Science & Technology; 分子对接; 合成; 新烟碱类; 杀虫活性; 生物活性; 类似物; COMPLEX; DOMAIN; N-oxide; CRYSTAL-STRUCTURE; ACHBP; CYTOTOXINS; computational chemical study; bioactivity; NICOTINIC ACETYLCHOLINE-RECEPTOR; BINDING-SITE; NITROMETHYLENE; NPA atomic charges; DERIVATIVES; REVEALS

Eight novel neonicotinoids N-oxide analogues were designed and synthesized. All the compounds have been identified by 1H NMR and HRMS. The N-oxide analogues exhibit high insecticidal activity against cowpea aphids （Aphis craccivora） at 250 mg,L-1. The influence of N-oxide formation on the biological...