Prognostic significance of pituitary tumour-transforming gene-binding factor (PBF) expression in papillary thyroid carcinoma

• Published in: Clinical endocrinology (Oxford) Vol. 78; no. 2; pp. 303 - 309
• Main Authors: Hsueh, Chuen, Lin, Jen-Der, Chang, Yu-Sun, Hsueh, Swei, Chao, Tzu-Chieh, Yu, Jau-Song, Jung, Shih-Ming, Tseng, Ngan-Ming, Sun, Jui-Hung, Kuo, Shau-Yun, Ueng, Shir-Hwa
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing Ltd 01.02.2013; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biological and medical sciences; Carcinoma, Papillary - metabolism; Carcinoma, Papillary - surgery; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation, Neoplastic - physiology; Humans; Male; Malignant tumors; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; Prognosis; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - surgery; Thyroid. Thyroid axis (diseases); Vertebrates: endocrinology; Young Adult; Endocrinopathy; Binding; Endocrine gland; Prognosis; Thyroid diseases; Pituitary gland; Malignant tumor; Gene expression; Papillary thyroid carcinoma; Endocrinology; Cancer

Summary Background Pituitary tumour‐transforming gene (PTTG)‐binding factor (PBF), originally known as PTTG1 interacting protein (PTTG1IP), has been found to be significantly increased in well‐differentiated thyroid cancer and independently associated with early tumour recurrence. Objective To asses...