Applications of induced pluripotent stem cell technologies in spinal cord injury

• Published in: Journal of neurochemistry Vol. 141; no. 6; pp. 848 - 860
• Main Authors: Nagoshi, Narihito, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2017
• Subjects: Abnormalities; Animal models; Animals; Axonogenesis; Cell Differentiation - physiology; cell transplantation; Cell- and Tissue-Based Therapy - methods; Central nervous system; clinical trial; Effectiveness; Embryo cells; Ethics; Fetuses; Humans; induced pluripotent stem cells; Induced Pluripotent Stem Cells - cytology; Inhibitors; Inhibitory postsynaptic potentials; Integration; Nervous system; Neural cell transplants; Neural networks; neural precursor cells; Neural Stem Cells - cytology; Neurochemistry; Neurons - cytology; Patients; Pluripotency; Regeneration (physiology); Regenerative medicine; Rehabilitation; Somatic cells; Spinal cord injuries; Spinal Cord Injuries - pathology; Spinal Cord Injuries - therapy; spinal cord injury; Stem cell transplantation; Stem cells; Therapeutic applications; Therapy; Tissue engineering; Transcription factors; Tumorigenesis; clinical trial; spinal cord injury; cell transplantation; induced pluripotent stem cells; neural precursor cells

Numerous basic research studies have suggested the potential efficacy of neural precursor cell (NPC) transplantation in spinal cord injury (SCI). However, in most such studies, the origin of the cells used was mainly fetal tissue or embryonic stem cells, both of which carry potential ethical concern...