Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

• Published in: Medicinal research reviews Vol. 37; no. 6; pp. 1492 - 1517
• Main Authors: Wong, Yin Kwan, Xu, Chengchao, Kalesh, Karunakaran A., He, Yingke, Lin, Qingsong, Wong, W. S. Fred, Shen, Han‐Ming, Wang, Jigang
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2017
• Subjects: Animals; anticancer; Antineoplastic Agents - pharmacology; artemisinin; Artemisinins - pharmacology; Cancer; chemical proteomics; Humans; mechanism of action; Molecular Targeted Therapy; Neoplasms - drug therapy; targets identification; artemisinin; mechanism of action; targets identification; chemical proteomics; anticancer

Artemisinin and its derivatives (collectively termed as artemisinins) are among the most important and effective antimalarial drugs, with proven safety and efficacy in clinical use. Beyond their antimalarial effects, artemisinins have also been shown to possess selective anticancer properties, demon...