Investigation and management of a raised serum ferritin

Summary Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflamma...

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Published inBritish journal of haematology Vol. 181; no. 3; pp. 331 - 340
Main Authors Cullis, Jonathan O., Fitzsimons, Edward J., Griffiths, William JH, Tsochatzis, Emmanouil, Thomas, D. Wayne
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.05.2018
Subjects
Ferritin
Ferritins - blood
Hematology
Humans
hyperferritinaemia
Inflammation - blood
Inflammation - therapy
Iron
iron metabolism
Iron Overload - blood
Iron Overload - therapy
Kidney Diseases - blood
Kidney Diseases - therapy
Liver diseases
Liver Diseases - blood
Liver Diseases - therapy
Malignancy
Management
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - therapy
Neoplasm Proteins - blood
Neoplasms - blood
Neoplasms - therapy
Practice Guidelines as Topic
Transferrins
iron metabolism
hyperferritinaemia
ferritin
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Abstract Summary Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.
AbstractList Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.
Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.
Summary Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably indicate reduced iron stores, raised serum ferritin levels can be due to multiple different aetiologies, including iron overload, inflammation, liver or renal disease, malignancy, and the recently described metabolic syndrome. A key test in the further investigation of an unexpected raised serum ferritin is the serum transferrin saturation. This guideline reviews the investigation and management of a raised serum ferritin level. The investigation and management of genetic haemochromatosis is not dealt with however and is the subject of a separate guideline.
Author Fitzsimons, Edward J.
Cullis, Jonathan O.
Griffiths, William JH
Tsochatzis, Emmanouil
Thomas, D. Wayne
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Issue 3
Keywords iron metabolism
hyperferritinaemia
ferritin
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1997; 90
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2009; 2009
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2007; 6
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2017; 176
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2008; 50
2003; 71
2016; 15
2008; 93
2001; 25
2010; 85
2015; 68
2015; 24
2012; 156
1991; 26
2015; 61
2011; 90
1973; 26
2002; 287
2018
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2015
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1999; 117
2008; 83
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Snippet Summary Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels...
Serum ferritin level is one of the most commonly requested investigations in both primary and secondary care. Whilst low serum ferritin levels invariably...
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SubjectTerms Ferritin
Ferritins - blood
Hematology
Humans
hyperferritinaemia
Inflammation - blood
Inflammation - therapy
Iron
iron metabolism
Iron Overload - blood
Iron Overload - therapy
Kidney Diseases - blood
Kidney Diseases - therapy
Liver diseases
Liver Diseases - blood
Liver Diseases - therapy
Malignancy
Management
Metabolic syndrome
Metabolic Syndrome - blood
Metabolic Syndrome - therapy
Neoplasm Proteins - blood
Neoplasms - blood
Neoplasms - therapy
Practice Guidelines as Topic
Transferrins
Title Investigation and management of a raised serum ferritin
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbjh.15166
https://www.ncbi.nlm.nih.gov/pubmed/29672840
https://www.proquest.com/docview/2030189607
https://www.proquest.com/docview/2028952972
Volume 181
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