Current and future treatments of pulmonary arterial hypertension

• Published in: British journal of pharmacology Vol. 178; no. 1; pp. 6 - 30
• Main Authors: Sommer, Natascha, Ghofrani, Hossein A., Pak, Oleg, Bonnet, Sebastien, Provencher, Steve, Sitbon, Olivier, Rosenkranz, Stephan, Hoeper, Marius M., Kiely, David G.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.01.2021
• Subjects: Apoptosis; Clinical trials; Endothelins; Epigenetics; Growth factor receptors; Hypertension; Ion channels; Prostacyclin; Pulmonary hypertension; Risk factors; Transcription factors

Therapeutic options for pulmonary arterial hypertension (PAH) have increased over the last decades. The advent of pharmacological therapies targeting the prostacyclin, endothelin, and NO pathways has significantly improved outcomes. However, for the vast majority of patients, PAH remains a life‐limi...