Pulmonary invasive mucinous adenocarcinoma

• Published in: Histopathology Vol. 84; no. 1; pp. 18 - 31
• Main Authors: Chang, Wei‐Chin, Zhang, Yu Zhi, Nicholson, Andrew G
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.01.2024
• Subjects: Adenocarcinoma; congenital pulmonary airway malformation; ErbB-2 protein; ERBB2; Genomics; invasive mucinous adenocarcinoma; Invasiveness; KRAS; lung adenocarcinoma; Metastases; NRG1; Vacuoles; invasive mucinous adenocarcinoma; KRAS; NRG1; congenital pulmonary airway malformation; ERBB2; lung adenocarcinoma

Invasive mucinous adenocarcinoma (IMA) is a relatively rare subtype of lung adenocarcinoma, composed of goblet and/or columnar tumour cells containing abundant intracytoplasmic mucin vacuoles. While a majority of IMAs are driven by KRAS mutations, recent studies have identified distinct genomic alte...