Early G1 Cyclin-Dependent Kinases as Prognostic Markers and Potential Therapeutic Targets in Esophageal Adenocarcinoma

• Published in: Clinical cancer research Vol. 17; no. 13; pp. 4513 - 4522
• Main Authors: ISMAIL, Amin, BANDLA, Santhoshi, PETERS, Jeffrey H, PENNATHUR, Arjun, LUKETICH, James D, GODFREY, Tony E, REVEILLER, Marie, TOIA, Liana, ZHONGREN ZHOU, GOODING, William E, KALATSKAYA, Irina, STEIN, Lincoln, D'SOUZA, Mary, LITLE, Virginia R
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.07.2011
• Subjects: Adenocarcinoma; Adenocarcinoma - diagnosis; Adenocarcinoma - enzymology; Adenocarcinoma - mortality; Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Biomarkers, Tumor - genetics; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; chromosome 7; Chromosomes, Human, Pair 7 - genetics; Cyclin-dependent kinase 4; Cyclin-Dependent Kinase 4 - antagonists & inhibitors; Cyclin-Dependent Kinase 4 - genetics; Cyclin-dependent kinase 6; Cyclin-Dependent Kinase 6 - antagonists & inhibitors; Cyclin-Dependent Kinase 6 - genetics; DNA Copy Number Variations - genetics; DNA microarrays; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - enzymology; Esophageal Neoplasms - mortality; Esophagus; Female; Gastroenterology. Liver. Pancreas. Abdomen; Gene Amplification - genetics; Gene expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Medical sciences; Middle Aged; Oncogenes; Pharmacology. Drug treatments; Piperazines - pharmacology; Prognosis; Protein Kinase Inhibitors - pharmacology; Pyridines - pharmacology; Single-nucleotide polymorphism; siRNA; Survival; Survival Analysis; Tumors; Prognosis; Targeting; Enzyme; Targeted therapy; Transferases; Esophageal disease; Biological marker; Malignant tumor; Esophagus cancer; G1 Phase; Treatment; Cell cycle; Digestive diseases; Esophagus adenocarcinoma; Early; Cyclin dependent kinase; Cancer

Chromosomal gain at 7q21 is a frequent event in esophageal adenocarcinoma (EAC). However, this event has not been mapped with fine resolution in a large EAC cohort, and its association with clinical endpoints and functional relevance are unclear. We used a cohort of 116 patients to fine map the 7q21...