Concise Review: Mesenchymal Stem Cells Derived from Human Pluripotent Cells, an Unlimited and Quality‐Controllable Source for Therapeutic Applications

• Published in: Stem cells (Dayton, Ohio) Vol. 37; no. 5; pp. 572 - 581
• Main Authors: Jiang, Bin, Yan, Li, Wang, Xiaoyan, Li, Enqin, Murphy, Kyle, Vaccaro, Kyle, Li, Yingcui, Xu, Ren‐He
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2019; Oxford University Press
• Subjects: Adipocytes; Adipocytes - cytology; Animal diseases; Animal health; Animal models; Biosafety; Cell Proliferation - genetics; Cell- and Tissue-Based Therapy; Cytokines; Derivation; Differentiation; Embryos; Exosomes; Genetic modification; Heterogeneity; Homeostasis; Human pluripotent stem cells; Humans; Immunomodulation; Inflammation; Mesenchymal Stem Cell Transplantation; Mesenchymal stem cells; Mesenchymal Stem Cells - cytology; Mesenchyme; Mesoderm; Mitochondria; Neural crest; Paracrine signalling; Pluripotency; Pluripotent Stem Cells - transplantation; Quality control; Stability; Stem cell transplantation; Stem cells; Therapeutic applications; Therapy; Three dimension; Derivation; Three dimension; Therapy; Human pluripotent stem cells; Mesenchymal stem cells

Despite the long discrepancy over their definition, heterogeneity, and functions, mesenchymal stem cells (MSCs) have proved to be a key player in tissue repair and homeostasis. Generally, somatic tissue‐derived MSCs (st‐MSCs) are subject to quality variations related to donated samples and biosafety...