Risk of Relapse of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Randomized Controlled Trial of Plasma Exchange and Glucocorticoids

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 76; no. 9; pp. 1431 - 1438
• Main Authors: Merkel, Peter A., Wald, Ron, Jayne, David, Walsh, Michael, Cass, Alan, Johnson, David W, Peh, Chen Au, Jeffs, Lisa, Ford, Sharon, Langham, Robyn, Sprangers, Ben, Brachemi, Soumeya, Clark, William, Reich, Heather, Barth, David, Cox, Gerry, Mazzetti, Andrea, Pavenski, Katerina, Tesar, Vladimir, Povlsen, Johan, Birn, Henrik, Pedersen, Erling B, Mesbah, Rafik, Chantrel, François, Vanhille, Philipe, Delluc, Aurélien, Hanrotel‐Saliou, Catherine, Augusto, Jean Francois, Chauveau, Dominique, Guitard, Joëlle, Seror, Raphaele, Mariette, Xavier, Lebas, Céline, Jourde‐Chiche, Noémie, Ruivard, Marc, Karras, Alexandre, Gibelin, Aude, Parrot, Antoine, Gregorini, Gina, Vaglio, Augusto, Muso, Eri, Kang, Youngna, Ariyasu, Yuki, Endo, Shuichiro, Miyata, Hitomi, Uchida, Shunya, Fujigaki, Yoshihide, Nanki, Toshihiro, Hamano, Yoshitomo, Fujimoto, Shouichi, Kikuchi, Masao, Sánchez‐Guerrero, Sergio A., Flores‐Suárez, Luis Felipe, Quincy, Vicki, Bruun, Trude Jannecke, Wludarczyk, Anna, Sznajd, Jan, Efvergren, Mats, Eriksson, Per, Heijl, Caroline, Ohlsson, Sophie, Segelmark, Marten, Kidder, Dana, Smith, Rona, Gopaluni, Seerapani, Brettell, Elizabeth, Howman, Andrew, Hughes, Terry, Sheerin, Alison Brown, Pusey, Charles, Tanna, Anisha, Griffith, Megan, Burton, James, Topham, Peter, Mitra, Sandip, Luqmani, Raashid, Morgan, Matthew, Foxton, Julie, Jones, Linda, Hough, Maxine, Oliveira, David, MacPhee, Iain AM, Dunn, Emma, Fan, Stanley Linsun, Quillen, Karen, Venuturupalli, Swamy, Koo, Anna, Winters, Jeff, Peikert, Tobias, Baqir, Misbah, Detwiler, Randy, Mottl, Amy, Derebail, Vimal, McGregor, JulieAnne, Sreih, Antoine, McAlear, Carol, Kiss, Joseph, Rees, Andrew, Scott, David, Landray, Martin
• Format: Journal Article
• Language: English
• Published: Boston, USA Wiley Periodicals, Inc 01.09.2024; Wiley Subscription Services, Inc
• Subjects: Adult; Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - drug therapy; Antibodies; Antineutrophil cytoplasmic antibodies; Apheresis; Clinical trials; Cyclophosphamide; Cyclophosphamide - therapeutic use; Dialysis; Female; Glucocorticoids; Glucocorticoids - therapeutic use; Humans; Induction therapy; Male; Middle Aged; Plasma Exchange - methods; Proteinase; Proteinase 3; Quality of life; Recurrence; Remission; Remission Induction; Tapering; Treatment Outcome; Vasculitis

Objective Relapses of antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis are important events that can cause organ dysfunction and reduce quality of life. Understanding the effects of the initial treatments for ANCA‐associated vasculitis on the subsequent risk of relapse may help guide...