Elevated IL-13Rα2 in intestinal epithelial cells from ulcerative colitis or colorectal cancer initiates MAPK pathway

• Published in: Inflammatory bowel diseases Vol. 16; no. 5; pp. 753 - 764
• Main Authors: Mandal, Debasmita, Levine, Alan D.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford University Press 01.05.2010; Wiley Subscription Services, Inc., A Wiley Company
• Subjects: colorectal cancer; IL‐13 receptor; MAP kinase; STAT6; ulcerative colitis

Background: Chronic inflammation in ulcerative colitis (UC) is a sizeable risk factor for colorectal cancer (CRC). Interleukin‐13 (IL‐13) is elevated in the UC mucosa and may induce dysregulated signaling in neighboring intestinal epithelial cells (IECs) and thus function as a tumorogenic cytokine....