Prognostic implication of BRAF and TERT promoter mutation combination in papillary thyroid carcinoma—A meta‐analysis

• Published in: Clinical endocrinology (Oxford) Vol. 87; no. 5; pp. 411 - 417
• Main Authors: Vuong, Huy Gia, Altibi, Ahmed M.A., Duong, Uyen N.P., Hassell, Lewis
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2017
• Subjects: BRAF mutation; BRAF V600E; Carcinoma, Papillary - diagnosis; Carcinoma, Papillary - genetics; Genotypes; Humans; Meta-analysis; Mutation; Papillary thyroid carcinoma; Prognosis; Promoter Regions, Genetic - genetics; Proto-Oncogene Proteins B-raf - genetics; review; Risk Assessment - methods; Risk groups; Telomerase - genetics; TERT promoter; Thyroid; Thyroid cancer; Thyroid Cancer, Papillary; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - genetics; Tumors; meta-analysis; BRAF V600E; papillary thyroid carcinoma; review; BRAF mutation; TERT promoter

Introduction The use of molecular markers, especially BRAF and TERT promoter mutations, for risk stratification in papillary thyroid carcinoma (PTC) is subject to continuing debate. In this study, we aimed to investigate the clinicopathological implication of each genotype when combining BRAF and TE...