Activation of the oncogenic miR‐21‐5p promotes HCV replication and steatosis induced by the viral core 3a protein

• Published in: Liver international Vol. 39; no. 7; pp. 1226 - 1236
• Main Authors: Clément, Sophie, Sobolewski, Cyril, Gomes, Diana, Rojas, Angela, Goossens, Nicolas, Conzelmann, Stéphanie, Calo, Nicolas, Negro, Francesco, Foti, Michelangelo
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.07.2019
• Subjects: Activation; Carcinogenesis; Carcinogens; Core protein; Egress; Gene expression; Hepatitis; Hepatitis C; Hepatocytes; Homology; Inhibition; Life cycles; lipid metabolism; Lipids; Mice; microRNA; miRNA; Particle production; phosphatase and tensin homolog; Proteins; PTEN protein; Replication; Ribonucleic acid; RNA; Steatosis; Suppressors; Tensin; Tumors; Virions; Viruses; microRNA; phosphatase and tensin homolog; hepatitis C; lipid metabolism

Background & aims miR‐21‐5p is a potent oncogenic microRNA targeting many key tumour suppressors including phosphatase and tensin homolog (PTEN). We recently identified PTEN as a key factor modulated by hepatitis C virus (HCV) to promote virion egress. In hepatocytes, expression of HCV‐3a core p...