Expression Quantitative Trait Locus Study of Bone Mineral Density GWAS Variants in Human Osteoclasts

• Published in: Journal of bone and mineral research Vol. 33; no. 6; pp. 1044 - 1051
• Main Authors: Mullin, Benjamin H, Zhu, Kun, Xu, Jiake, Brown, Suzanne J, Mullin, Shelby, Tickner, Jennifer, Pavlos, Nathan J, Dudbridge, Frank, Walsh, John P, Wilson, Scott G
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2018
• Subjects: Bioinformatics; Bone density; Bone mineral density; CELL/TISSUE SIGNALING — PARACRINE PATHWAYS; Chromosome 15; Genetic diversity; GENETIC RESEARCH; Genotype & phenotype; HUMAN ASSOCIATION STUDIES; IQGAP1 protein; Linkage disequilibrium; OSTEOCLASTS; OSTEOPOROSIS; Quantitative trait loci; Regulatory sequences; Single-nucleotide polymorphism; OSTEOCLASTS; HUMAN ASSOCIATION STUDIES; CELL/TISSUE SIGNALING - PARACRINE PATHWAYS; GENETIC RESEARCH; OSTEOPOROSIS

ABSTRACT Osteoporosis is a complex disease with a strong genetic component. Genomewide association studies (GWAS) have been very successful at identifying common genetic variants associated with bone parameters. A recently published study documented the results of the largest GWAS for bone mineral d...