Methodological consensus on clinical proton MRS of the brain: Review and recommendations

• Published in: Magnetic resonance in medicine Vol. 82; no. 2; pp. 527 - 550
• Main Authors: Wilson, Martin, Andronesi, Ovidiu, Barker, Peter B., Bartha, Robert, Bizzi, Alberto, Bolan, Patrick J., Brindle, Kevin M., Choi, In‐Young, Cudalbu, Cristina, Dydak, Ulrike, Emir, Uzay E., Gonzalez, Ramon G., Gruber, Stephan, Gruetter, Rolf, Gupta, Rakesh K., Heerschap, Arend, Henning, Anke, Hetherington, Hoby P., Huppi, Petra S., Hurd, Ralph E., Kantarci, Kejal, Kauppinen, Risto A, Klomp, Dennis W. J., Kreis, Roland, Kruiskamp, Marijn J., Leach, Martin O., Lin, Alexander P., Luijten, Peter R., Marjańska, Małgorzata, Maudsley, Andrew A., Meyerhoff, Dieter J., Mountford, Carolyn E., Mullins, Paul G., Murdoch, James B., Nelson, Sarah J., Noeske, Ralph, Öz, Gülin, Pan, Julie W., Peet, Andrew C., Poptani, Harish, Posse, Stefan, Ratai, Eva‐Maria, Salibi, Nouha, Scheenen, Tom W. J., Smith, Ian C. P., Soher, Brian J., Tkáč, Ivan, Vigneron, Daniel B., Howe, Franklyn A.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.08.2019
• Subjects: Adiabatic; Adiabatic flow; Biomarkers; Brain; Brain - diagnostic imaging; Brain - metabolism; Consensus; Hardware; Humans; Localization; Magnetic Resonance Imaging - methods; metabolites; MRS; Protons; R&D; Research & development; Scanners; semi‐LASER; shimming; Therapeutic applications; consensus; shimming; brain; metabolites; MRS; semi-LASER

Proton MRS (1H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good acc...