Intravenous Infusion of Human Adipose Mesenchymal Stem Cells Modifies the Host Response to Lipopolysaccharide in Humans: A Randomized, Single‐Blind, Parallel Group, Placebo Controlled Trial

• Published in: Stem cells (Dayton, Ohio) Vol. 36; no. 11; pp. 1778 - 1788
• Main Authors: Perlee, Desiree, van Vught, Lonneke A., Scicluna, Brendon P., Maag, Anja, Lutter, René, Kemper, Elles M., van ‘t Veer, Cornelis, Punchard, Marie A., González, Jesús, Richard, Marie Paule, Dalemans, Wilfried, Lombardo, Eleuterio, de Vos, Alex F., van der Poll, Tom
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.11.2018; Oxford University Press
• Subjects: Adipose stem cells; Blood; Cell activation; Cellular therapy; Clinical trials; Coagulation; Cytokines; Endotoxemia; Fibrin; Gene expression; Genes; Growth factors; Immune response; Inflammation; Interleukins; Intravenous administration; Intravenous infusion; Leukocytes; Lipopolysaccharides; Mesenchymal stem cells; Mesenchyme; Pathogenesis; Randomization; Sepsis; Stem cells; Transforming growth factor; Transforming growth factor-b; adipose stem cells; clinical trials; cellular therapy; mesenchymal stem cells

In experimental models, mesenchymal stem cells (MSCs) can modulate various immune responses implicated in the pathogenesis of sepsis. Intravenous injection of lipopolysaccharide (LPS) into healthy subjects represents a model with relevance for the host response to sepsis. To explore the use of MSCs...