Ischaemia reperfusion injury in liver transplantation: Cellular and molecular mechanisms

• Published in: Liver international Vol. 39; no. 5; pp. 788 - 801
• Main Authors: Dar, Wasim A., Sullivan, Elise, Bynon, John S., Eltzschig, Holger, Ju, Cynthia
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019
• Subjects: Activation; Autophagy; Endothelial cells; Gene expression; Health risks; Hepatocytes; Hypoxia; hypoxia‐inducible factors; ischaemia reperfusion; Ischemia; Kupffer cells; Leukocytes (neutrophilic); Liver; Liver diseases; Liver transplantation; Molecular modelling; Phagocytosis; Platelets; Reperfusion; Ribonucleic acid; Risk analysis; Risk factors; RNA; Signal transduction; Steatosis; therapeutics; Toll-like receptors; Transplantation; hypoxia-inducible factors; therapeutics; ischaemia reperfusion; liver transplantation

Liver disease causing end organ failure is a growing cause of mortality. In most cases, the only therapy is liver transplantation. However, liver transplantation is a complex undertaking and its success is dependent on a number of factors. In particular, liver transplantation is subject to the risks...