Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis

• Published in: Hepatology (Baltimore, Md.) Vol. 71; no. 3; pp. 972 - 989
• Main Authors: Carpino, Guido, Nevi, Lorenzo, Overi, Diletta, Cardinale, Vincenzo, Lu, Wei‐Yu, Di Matteo, Sabina, Safarikia, Samira, Berloco, Pasquale Bartolomeo, Venere, Rosanna, Onori, Paolo, Franchitto, Antonio, Forbes, Stuart J., Alvaro, Domenico, Gaudio, Eugenio
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.03.2020
• Subjects: Adult; Aged; Animals; Bile; Bile ducts; Biliary tract; Biliary Tract - cytology; Biliary Tract - physiopathology; Cell activation; Cell Differentiation; Cholangitis; Cholangitis, Sclerosing - physiopathology; Cholangitis, Sclerosing - therapy; Epithelium; Female; Fibrosis; Hepatology; Humans; Hyperplasia; Immunohistochemistry; Inflammation; Kinases; Male; Mice; Mice, Inbred C57BL; Middle Aged; Organ donors; Polymerase chain reaction; Progenitor cells; Pyridines - toxicity; Receptors, Notch - physiology; Regeneration - physiology; Signal transduction; Sox9 protein; Stem Cell Niche - physiology; Stem cells; Stromal cells; Western blotting; Wnt protein; Wnt Signaling Pathway - physiology
• ISSN: 0270-9139; 1527-3350; 1527-3350
• DOI: 10.1002/hep.30871

Background and Aims Mechanisms underlying the repair of extrahepatic biliary tree (EHBT) after injury have been scarcely explored. The aims of this study were to evaluate, by using a lineage tracing approach, the contribution of peribiliary gland (PBG) niche in the regeneration of EHBT after damage...