Nucleotide Second Messenger‐Mediated Regulation of a Muralytic Enzyme in Streptomyces

• Published in: Molecular microbiology Vol. 96; no. 4; pp. 779 - 795
• Main Authors: St‐Onge, Renée J., Haiser, Henry J., Yousef, Mary R., Sherwood, Emma, Tschowri, Natalia, Al‐Bassam, Mahmoud, Elliot, Marie A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2015
• Subjects: Aconitate Hydratase - genetics; Aconitate Hydratase - isolation & purification; Aconitate Hydratase - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - isolation & purification; Bacterial Proteins - metabolism; Cell Wall - metabolism; Cyclic AMP - metabolism; Cyclic AMP Receptor Protein - genetics; Cyclic AMP Receptor Protein - metabolism; Enzymes; Gene Expression Regulation, Bacterial; Gram-positive bacteria; Guanine Nucleotides - metabolism; Microbiology; Mutation; Peptidoglycan - metabolism; Promoter Regions, Genetic; Proteins; Riboswitch - genetics; Second Messenger Systems; Streptomyces coelicolor - enzymology; Streptomyces coelicolor - genetics; Streptomyces coelicolor - growth & development; Streptomyces coelicolor - metabolism; Transcription factors

Summary Peptidoglycan degradative enzymes have important roles at many stages during the bacterial life cycle, and it is critical that these enzymes be stringently regulated to avoid compromising the integrity of the cell wall. How this regulation is exerted is of considerable interest: promoter‐bas...