Binge drinking induces an acute burst of markers of hepatic fibrogenesis (PRO‐C3)

• Published in: Liver international Vol. 42; no. 1; pp. 92 - 101
• Main Authors: Torp, Nikolaj, Israelsen, Mads, Nielsen, Mette J., Åstrand, Claus P., Juhl, Pernille, Johansen, Stine, Hansen, Camilla D., Madsen, Bjørn, Villesen, Ida F., Leeming, Diana J., Thiele, Maja, Hansen, Torben, Karsdal, Morten, Krag, Aleksander
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2022
• Subjects: Acute effects; acute intoxication; Atomic layer epitaxy; Binge drinking; Binge Drinking - complications; biomarker; cirrhosis; Collagen (type I); Complement C3 - analysis; Degradation; Drinking behavior; Ethanol; Ethanol - adverse effects; Extracellular matrix; Fatty liver; Fibrosis; Health risks; Hepatic vein; Humans; Liver; Liver diseases; Markers; Morbidity; Non-alcoholic Fatty Liver Disease; Sodium chloride; fibrosis; acute intoxication; biomarker; cirrhosis; extracellular matrix

Background & Aims Binge drinking is associated with an increased risk of liver disease. Morbidity and mortality of alcohol‐related liver disease (ALD) is associated with collagen deposition in the hepatic extracellular matrix (ECM). However, the acute effects of binge drinking on ECM turnover ar...