Open Access UHPSFC/MS - an additional analytical resource for an academic mass spectrometry facility
Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supe...
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Published in | Rapid communications in mass spectrometry Vol. 30; no. 15; pp. 1811 - 1817 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Blackwell Publishing Ltd
15.08.2016
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Abstract | Rationale
Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation.
Methods
A UPC2‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™).
Results
Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports.
Conclusions
The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. |
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AbstractList | Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. Methods A UPC2-TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer(TM)). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation. Methods A UPC2‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation. Methods A UPC 2 ‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. Methods A UPC super(2)-TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer(TM)). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. A UPC(2) -TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer™). Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. RATIONALEMany compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation.METHODSA UPC(2) -TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer™).RESULTSCompounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports.CONCLUSIONSThe implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd. |
Author | Langley, G. John Herniman, Julie M. |
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CitedBy_id | crossref_primary_10_1002_rcm_7792 crossref_primary_10_1002_chir_23081 crossref_primary_10_1016_j_jchromb_2018_06_021 crossref_primary_10_1002_rcm_7825 crossref_primary_10_1002_jssc_201901130 |
Cites_doi | 10.1002/rcm.1290090216 10.1002/jms.360 10.1016/1044-0305(95)00028-C 10.1002/jms.673 10.1016/j.aca.2014.03.034 10.1016/j.chroma.2009.07.022 10.1016/j.chroma.2007.10.020 10.1002/1096-9888(200010)35:10<1157::AID-JMS68>3.0.CO;2-E 10.1016/1044-0305(94)00124-1 10.1002/rcm.1290080812 10.1021/acs.energyfuels.5b00103 10.1002/jms.363 |
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References_xml | – volume: 1216 start-page: 6441 year: 2009 article-title: The effect of increasing concentration of ammonium acetate as an additive in supercritical fluid chromatography using CO ‐methanol mobile phase publication-title: J. Chromatogr. A – volume: 824 start-page: 18 year: 2014 article-title: Modern analytical supercritical fluid chromatography using columns packed with sub‐2 μm particles: A tutorial publication-title: Anal. Chim. Acta – volume: 8 start-page: 632 year: 1994 article-title: An automated open‐access service to synthetic chemists: Thermospray mass spectrometry publication-title: Rapid Commun. Mass Spectrom. – volume: 9 start-page: 188 year: 1995 article-title: Automated liquid chromatography/mass spectrometry for chromatographers publication-title: Rapid Commun. Mass Spectrom. – volume: 37 start-page: 889 year: 2002 article-title: Open‐access liquid chromatography/mass spectrometry in a drug discovery environment publication-title: J. Mass Spectrom. – volume: 39 start-page: 942 year: 2004 article-title: Open‐access high‐resolution mass spectrometry in early drug discovery publication-title: J. Mass Spectrom. – volume: 1189 start-page: 254 year: 2008 article-title: Using calculated molecular descriptors to predict retention of sulfonamides in supercritical fluid chromatography publication-title: J. Chromatogr. A – volume: 37 start-page: 777 year: 2002 article-title: Operation of an academic open access mass spectrometry facility with particular reference to the analysis of synthetic compounds publication-title: J. Mass Spectrom. – volume: 29 start-page: 2485 year: 2015 article-title: Evaluation of ultrahigh‐performance supercritical fluid‐chromatography as an alternative approach for the analysis of fatty acid methyl esters in aviation turbine fuel publication-title: Energy Fuels – volume: 35 start-page: 1157 year: 2000 article-title: Organization, management and operation of contemporary academic mass spectrometry service facilities publication-title: J. Mass Spectrom. – volume: 6 start-page: 387 year: 1995 article-title: Open access atmospheric pressure chemical ionisation mass spectrometry for routine sample analysis publication-title: J. Am. Soc. Mass Spectrom. – volume: 6 start-page: 394 year: 1995 article-title: Putting mass spectrometry in the hands of the end user publication-title: J. Am. Soc. Mass Spectrom. – ident: e_1_2_6_4_1 doi: 10.1002/rcm.1290090216 – ident: e_1_2_6_5_1 doi: 10.1002/jms.360 – ident: e_1_2_6_3_1 doi: 10.1016/1044-0305(95)00028-C – ident: e_1_2_6_6_1 doi: 10.1002/jms.673 – ident: e_1_2_6_13_1 doi: 10.1016/j.aca.2014.03.034 – ident: e_1_2_6_10_1 doi: 10.1016/j.chroma.2009.07.022 – ident: e_1_2_6_11_1 doi: 10.1016/j.chroma.2007.10.020 – ident: e_1_2_6_7_1 doi: 10.1002/1096-9888(200010)35:10<1157::AID-JMS68>3.0.CO;2-E – ident: e_1_2_6_8_1 doi: 10.1016/1044-0305(94)00124-1 – ident: e_1_2_6_2_1 doi: 10.1002/rcm.1290080812 – ident: e_1_2_6_12_1 doi: 10.1021/acs.energyfuels.5b00103 – ident: e_1_2_6_9_1 doi: 10.1002/jms.363 |
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Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase... Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase... Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase... RATIONALEMany compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase... |
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Title | Open Access UHPSFC/MS - an additional analytical resource for an academic mass spectrometry facility |
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