Open Access UHPSFC/MS - an additional analytical resource for an academic mass spectrometry facility

Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supe...

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Published inRapid communications in mass spectrometry Vol. 30; no. 15; pp. 1811 - 1817
Main Authors Herniman, Julie M., Langley, G. John
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 15.08.2016
Wiley Subscription Services, Inc
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Abstract Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation. Methods A UPC2‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
AbstractList Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. Methods A UPC2-TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer(TM)). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation. Methods A UPC2‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase ultra‐high‐performance liquid chromatography/mass spectrometry (RP‐UHPLC/MS) and require analysis via infusion. An ultra‐high‐performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high‐throughput analysis of these compounds with chromatographic separation. Methods A UPC 2 ‐TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web‐based interface (RemoteAnalyzer™). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP‐UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed‐phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. Methods A UPC super(2)-TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer(TM)). Results Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. Conclusions The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options.
Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation. A UPC(2) -TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer™). Compounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports. The implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
RATIONALEMany compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase ultra-high-performance liquid chromatography/mass spectrometry (RP-UHPLC/MS) and require analysis via infusion. An ultra-high-performance supercritical fluid chromatography mass spectrometry approach was implemented to afford high-throughput analysis of these compounds with chromatographic separation.METHODSA UPC(2) -TQD MS system has been incorporated into the open access MS provision within Chemistry at the University of Southampton, using an ESCi source (electrospray and atmospheric pressure chemical ionization) and an atmospheric pressure photoionization (APPI) source. Access to instrumentation is enabled via a web-based interface (RemoteAnalyzer™).RESULTSCompounds such as fluorosugars, fullerenes, phosphoramidites, porphyrins, and rotaxanes exhibiting properties incompatible with RP-UHPLC/MS have been analyzed using automated chromatography and mass spectrometry methods. The speedy return of data enables research in these areas to progress unhindered by sample type. The provision of an electronic web format enables easy incorporation of chromatograms and mass spectra into electronic files and reports.CONCLUSIONSThe implementation of UHPSFC/MS increases access to a wide range of chemistries incompatible with reversed-phase chromatography and polar solvents, enabling more than 90% of submitted samples to be analyzed using an open access approach. Further, chromatographic separation is provided where previously flow injection or infusion analyses were the only options. Copyright © 2016 John Wiley & Sons, Ltd.
Author Langley, G. John
Herniman, Julie M.
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CitedBy_id crossref_primary_10_1002_rcm_7792
crossref_primary_10_1002_chir_23081
crossref_primary_10_1016_j_jchromb_2018_06_021
crossref_primary_10_1002_rcm_7825
crossref_primary_10_1002_jssc_201901130
Cites_doi 10.1002/rcm.1290090216
10.1002/jms.360
10.1016/1044-0305(95)00028-C
10.1002/jms.673
10.1016/j.aca.2014.03.034
10.1016/j.chroma.2009.07.022
10.1016/j.chroma.2007.10.020
10.1002/1096-9888(200010)35:10<1157::AID-JMS68>3.0.CO;2-E
10.1016/1044-0305(94)00124-1
10.1002/rcm.1290080812
10.1021/acs.energyfuels.5b00103
10.1002/jms.363
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Snippet Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed‐phase...
Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase...
Rationale Many compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase...
RATIONALEMany compounds submitted for analysis in Chemistry at the University of Southampton do not retain, elute or ionize using open access reversed-phase...
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SubjectTerms Atmospheric pressure
Barometric pressure
Chromatography
Electronics
Infusion
Liquid chromatography
Mass spectrometry
Separation
Title Open Access UHPSFC/MS - an additional analytical resource for an academic mass spectrometry facility
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Volume 30
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