Restricted expression of EBV latent genes and T‐lymphocyte‐detected membrane antigen in Burkitt's lymphoma cells
Certain newly established Epstein‐Barr virus‐containing Burkitt's lymphoma cell lines do not express the cytotoxic T‐lymphocyte‐detected membrane antigen (LYDMA) through which EBV infection is normally controlled by the host. When the EB virus recovered from these BL lines was used to transform...
Saved in:
Published in | The EMBO journal Vol. 5; no. 10; pp. 2599 - 2607 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group
01.10.1986
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Certain newly established Epstein‐Barr virus‐containing Burkitt's lymphoma cell lines do not express the cytotoxic T‐lymphocyte‐detected membrane antigen (LYDMA) through which EBV infection is normally controlled by the host. When the EB virus recovered from these BL lines was used to transform peripheral blood lymphocytes from seronegative donors, the lymphoblastoid cell lines (LCLs) that arose were all LYDMA positive. This indicates that the LYDMA‐negative nature of the BLs is not the result of a mutation in the resident viral genome but is rather a specific adaptation in those cells, perhaps permitting evasion of the host immune surveillance in tumour development. A comparison of the EBV gene expression in six LYDMA‐negative and two LYDMA‐positive BL lines and in their corresponding LCLs revealed that several of the BL lines did not express all of the viral gene products classically associated with latent transformation by EBV. Four out of eight cell lines showed restricted expression of the latent membrane protein (LMP) and/or the EB nuclear antigen, EBNA 2. A new level of EBV gene regulation therefore appears to be operating in some of the BL cell lines. The patterns of expression of EBV genes in the cell lines did not show any correlation with the known susceptibility of the lines to T cell killing. |
---|---|
AbstractList | Certain newly established Epstein‐Barr virus‐containing Burkitt's lymphoma cell lines do not express the cytotoxic T‐lymphocyte‐detected membrane antigen (LYDMA) through which EBV infection is normally controlled by the host. When the EB virus recovered from these BL lines was used to transform peripheral blood lymphocytes from seronegative donors, the lymphoblastoid cell lines (LCLs) that arose were all LYDMA positive. This indicates that the LYDMA‐negative nature of the BLs is not the result of a mutation in the resident viral genome but is rather a specific adaptation in those cells, perhaps permitting evasion of the host immune surveillance in tumour development. A comparison of the EBV gene expression in six LYDMA‐negative and two LYDMA‐positive BL lines and in their corresponding LCLs revealed that several of the BL lines did not express all of the viral gene products classically associated with latent transformation by EBV. Four out of eight cell lines showed restricted expression of the latent membrane protein (LMP) and/or the EB nuclear antigen, EBNA 2. A new level of EBV gene regulation therefore appears to be operating in some of the BL cell lines. The patterns of expression of EBV genes in the cell lines did not show any correlation with the known susceptibility of the lines to T cell killing. Certain newly established Epstein-Barr virus-containing Burkitt's lymphoma cell lines do not express the cytotoxic T-lympocyte-detected membrane antigen (LYDMA) through which EBV infection is normally controlled by the host. When the EB virus recovered from these BL lines was used to transform peripheral blood lymphocytes from seronegative donors, the lymphoblastoid cell lines (LCLs) that arose were all LYDMA positive. A comparision of the EBV gene expression in six LYDMA-negative and two LYDMA-positive BL lines and in their corresponding LCLs revealed that several of the BL lines did not express all of the viral gene products classically associated with latent transformation by EBV. |
Author | Rickinson, A.B. Rowe, D.T. Rowe, M. Evan, G.I. Wallace, L.E. Farrell, P.J. |
Author_xml | – sequence: 1 givenname: D.T. surname: Rowe fullname: Rowe, D.T. – sequence: 2 givenname: M. surname: Rowe fullname: Rowe, M. – sequence: 3 givenname: G.I. surname: Evan fullname: Evan, G.I. – sequence: 4 givenname: L.E. surname: Wallace fullname: Wallace, L.E. – sequence: 5 givenname: P.J. surname: Farrell fullname: Farrell, P.J. – sequence: 6 givenname: A.B. surname: Rickinson fullname: Rickinson, A.B. |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7870494$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/3023050$$D View this record in MEDLINE/PubMed |
BookMark | eNqVkc1u1DAUhS3UqkwLj4BkIQSrpNdJHCcsKnWqAVoVIaHC1nKcm9ZDfgbbAzM7HoFn5ElwZqIRrBAr2zrfubrH55Qc9UOPhDxnEDOA5HwZsyyHKAHBY1YWeewryHgG8eYRmR2kIzKDJGdRxoryMTl1bgkAvBDshJykkKTAYUb8R3TeGu2xprhZWXTODD0dGrqYf6at8th7eo89Oqr6mt79-vGz3Xarh0FvPYZHjR535g67yqoeA-ZNMFDT0_nafjHev3J07-kU1di27gk5blTr8Ol0npFPbxZ3V--i2w9vr68ubyM9pol4UupaIZYVKKgyrlWV5yGABlRVlqZa8bTmImVFknJVqZKVGpiqStXUGS-z9Ixc7Oeu1lWHtQ5ZrGrlyppO2a0clJF_K715kPfDN8lYLhgvwoCX0wA7fF2Hn5KdcWOEEHRYOykEywGE-CcYSmGiKFgAX-9BbQfnLDaHbRjIsVy5HGGQY4NyLFdO5cpNMD_7M8_BOrUZ9BeTrpxWbRP60MYdMFEIyHbfcrnHvpsWt_-xgFy8n9_s7ulv5-LIgg |
CODEN | EMJODG |
CitedBy_id | crossref_primary_10_1038_onc_2009_359 crossref_primary_10_1556_AMicr_57_2010_4_3 crossref_primary_10_1016_0168_1702_93_90112_Z crossref_primary_10_1002__SICI_1097_0215_19990331_81_1_6__AID_IJC2_3_0_CO_2_2 crossref_primary_10_1002_ijc_2910420305 crossref_primary_10_1128_JVI_75_6_2584_2596_2001 crossref_primary_10_1111_j_1600_065X_1999_tb01328_x crossref_primary_10_1002_ijc_1404 crossref_primary_10_3390_v9110339 crossref_primary_10_1016_0304_419X_89_90002_4 crossref_primary_10_1007_BF00838051 crossref_primary_10_1016_S0198_8859_97_00083_9 crossref_primary_10_1002_ijc_2910410625 crossref_primary_10_1038_s41418_019_0435_1 crossref_primary_10_1098_rstb_2000_0783 crossref_primary_10_1128_JVI_73_3_1980_1989_1999 crossref_primary_10_3390_ijms23073434 crossref_primary_10_1002_ijc_2910460605 crossref_primary_10_1111_j_1439_0388_1988_tb00278_x crossref_primary_10_1186_2042_4280_2_8 crossref_primary_10_1002_ijc_2910610315 crossref_primary_10_1007_BF02934513 crossref_primary_10_1016_0161_5890_93_90112_O crossref_primary_10_1007_BF01741347 crossref_primary_10_1128_JVI_74_21_10223_10228_2000 crossref_primary_10_1016_0959_8049_93_90299_U crossref_primary_10_1002_ijc_24223 crossref_primary_10_1126_science_7682013 crossref_primary_10_1158_1078_0432_CCR_09_2424 crossref_primary_10_1016_S0145_2126_97_00173_2 crossref_primary_10_1016_S0304_3835_01_00733_9 crossref_primary_10_1038_sj_onc_1207372 crossref_primary_10_1016_S0950_3536_11_80035_1 crossref_primary_10_1128_JVI_03003_12 crossref_primary_10_1002_jmv_1890330303 crossref_primary_10_1007_s00705_023_05933_0 crossref_primary_10_1016_j_semcancer_2008_10_008 crossref_primary_10_1016_S1040_8428_97_00233_3 crossref_primary_10_1111_j_1365_2141_2010_08159_x crossref_primary_10_1016_0042_6822_90_90036_Q crossref_primary_10_1111_j_1349_7006_1992_tb01948_x crossref_primary_10_1056_NEJM199805143382003 crossref_primary_10_1038_onc_2009_258 crossref_primary_10_1007_BF02634361 crossref_primary_10_1515_BC_2001_174 crossref_primary_10_1371_journal_pone_0186614 crossref_primary_10_1002_ijc_2910530416 crossref_primary_10_1007_BF00201465 crossref_primary_10_3389_fcimb_2020_606412 crossref_primary_10_1007_BF02918170 crossref_primary_10_1128_MCB_19_3_1651 crossref_primary_10_1056_NEJM198910193211604 crossref_primary_10_1002_ijc_2910400313 crossref_primary_10_1089_dna_1995_14_767 crossref_primary_10_1111_j_1601_0825_1996_tb00211_x crossref_primary_10_1002_1097_0215_20001201_88_5_744__AID_IJC10_3_0_CO_2_E crossref_primary_10_1006_viro_2000_0582 crossref_primary_10_1016_0042_6822_88_90530_2 crossref_primary_10_1128_MCB_17_2_873 crossref_primary_10_1056_NEJM199201023260103 crossref_primary_10_4049_jimmunol_0803572 crossref_primary_10_1016_0165_2478_88_90179_4 crossref_primary_10_1002_ijc_2910390317 crossref_primary_10_1016_S1040_8428_02_00078_1 crossref_primary_10_1371_journal_ppat_1004042 crossref_primary_10_1002_ijc_2910500217 crossref_primary_10_1016_0092_8674_89_90394_2 crossref_primary_10_1016_S1044_579X_02_00101_3 crossref_primary_10_1016_0042_6822_88_90546_6 crossref_primary_10_1002_jcb_22920 crossref_primary_10_1016_j_semcancer_2009_07_004 crossref_primary_10_1111_j_1749_6632_1993_tb43999_x crossref_primary_10_1016_j_semcancer_2009_07_002 crossref_primary_10_1016_j_semcancer_2009_07_005 crossref_primary_10_1002_ijc_2910450623 crossref_primary_10_1006_viro_1998_9441 crossref_primary_10_1111_j_1365_2141_2011_09007_x crossref_primary_10_1111_j_1749_6632_1997_tb46212_x crossref_primary_10_1002_stem_5530100602 crossref_primary_10_3109_10428199409051672 crossref_primary_10_1089_dna_1997_16_1311 crossref_primary_10_1002_ijc_2910400521 crossref_primary_10_4049_jimmunol_174_11_6829 crossref_primary_10_1002_jmv_24254 crossref_primary_10_1016_0090_1229_89_90037_8 crossref_primary_10_26508_lsa_202101355 crossref_primary_10_1002_1097_0142_19920201_69_3_763__AID_CNCR2820690325_3_0_CO_2 crossref_primary_10_1002_ijc_2910460418 crossref_primary_10_1016_S0042_6822_95_80033_6 crossref_primary_10_1097_00007890_199609270_00030 |
ContentType | Journal Article |
Copyright | 1986 European Molecular Biology Organization 1987 INIST-CNRS |
Copyright_xml | – notice: 1986 European Molecular Biology Organization – notice: 1987 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 8FD FR3 H94 P64 RC3 7X8 5PM |
DOI | 10.1002/j.1460-2075.1986.tb04540.x |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Immunology Abstracts Virology and AIDS Abstracts Technology Research Database Engineering Research Database AIDS and Cancer Research Abstracts Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Genetics Abstracts Virology and AIDS Abstracts Technology Research Database AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
DatabaseTitleList | Genetics Abstracts MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Chemistry Biology |
EISSN | 1460-2075 |
EndPage | 2607 |
ExternalDocumentID | 10_1002_j_1460_2075_1986_tb04540_x 3023050 7870494 EMBJ04540 |
Genre | article Research Support, Non-U.S. Gov't Journal Article |
GroupedDBID | --- -DZ -Q- -~X .55 0R~ 123 1OC 24P 29G 2WC 33P 36B 39C 3O- 3V. 4.4 53G 5VS 70F 7X7 88A 88E 8AO 8C1 8CJ 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 A8Z AAESR AAEVG AAHBH AAHHS AAIHA AANLZ AAONW AASGY AAXRX AAZKR ABCUV ABJNI ABLJU ABUWG ABZEH ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACKIV ACNCT ACPOU ACPRK ACSMW ACXBN ACXQS ADBBV ADEOM ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEGXH AEIGN AENEX AEQDE AEUYR AFBPY AFFNX AFGKR AFKRA AFPWT AFRAH AFZJQ AHMBA AI. AIAGR AIURR AIWBW AJBDE ALAGY ALIPV ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB AOIJS ASPBG AUFTA AVWKF AZBYB AZFZN AZQEC AZVAB BAWUL BBNVY BDRZF BENPR BFHJK BHPHI BKSAR BMNLL BMXJE BPHCQ BRXPI BTFSW BVXVI C1A C6C CAG CCPQU COF CS3 D1J DCZOG DIK DPXWK DRFUL DRSTM DU5 DWQXO E3Z EBD EBLON EBS EJD EMB EMOBN ESTFP F5P FA8 FEDTE FYUFA G-S GNUQQ GODZA GROUPED_DOAJ GUQSH GX1 H13 HCIFZ HH5 HK~ HMCUK HVGLF HYE H~9 KQ8 LATKE LEEKS LH4 LITHE LK8 LOXES LUTES LW6 LYRES M0L M1P M2O M7P MEWTI MRFUL MRSTM MSFUL MSSTM MVM MXFUL MXSTM MY~ O9- OK1 P2P P2W PCBAR PQQKQ PROAC PSQYO Q2X R.K RHF RHI RIG RNI RNS ROL RPM RZO SV3 TN5 TR2 UKHRP VH1 WBKPD WH7 WIH WIK WIN WOHZO WOQ WXSBR WYJ X7M XSW Y6R YSK YYP ZCA ZGI ZXP ZZTAW ~KM 08R AAJUZ ABCVL ABHUG ABPTK ACXME ADAWD ADDAD AEUQT AFVGU AGJLS IQODW SUPJJ XFK ZA5 CGR CUY CVF ECM EIF NPM AAYXX CITATION 7T5 7U9 8FD FR3 H94 P64 RC3 7X8 5PM |
ID | FETCH-LOGICAL-c4540-529cdaee9b0a0b45cab66587c0eab433ca53d57318235aba919c01ab9afd45943 |
IEDL.DBID | RPM |
ISSN | 0261-4189 |
IngestDate | Tue Sep 17 21:26:09 EDT 2024 Fri Aug 16 05:03:59 EDT 2024 Sat Aug 17 01:21:23 EDT 2024 Fri Aug 23 02:00:59 EDT 2024 Sat Sep 28 08:19:40 EDT 2024 Sun Oct 29 17:08:31 EDT 2023 Sat Aug 24 01:14:56 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | Human Cell culture Herpesviridae Burkitt lymphoma Cytotoxicity Cellular immunity Epstein Barr virus Gene expression Infection Virus Viral disease Established cell line T»-Lymphocyte γ-Herpesvirinae |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c4540-529cdaee9b0a0b45cab66587c0eab433ca53d57318235aba919c01ab9afd45943 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
OpenAccessLink | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/j.1460-2075.1986.tb04540.x |
PMID | 3023050 |
PQID | 14617881 |
PQPubID | 23462 |
PageCount | 9 |
ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_1167158 proquest_miscellaneous_77160077 proquest_miscellaneous_14617881 crossref_primary_10_1002_j_1460_2075_1986_tb04540_x pubmed_primary_3023050 pascalfrancis_primary_7870494 wiley_primary_10_1002_j_1460_2075_1986_tb04540_x_EMBJ04540 |
PublicationCentury | 1900 |
PublicationDate | October 1986 |
PublicationDateYYYYMMDD | 1986-10-01 |
PublicationDate_xml | – month: 10 year: 1986 text: October 1986 |
PublicationDecade | 1980 |
PublicationPlace | London |
PublicationPlace_xml | – name: London – name: England |
PublicationTitle | The EMBO journal |
PublicationTitleAlternate | EMBO J |
PublicationYear | 1986 |
Publisher | Nature Publishing Group |
Publisher_xml | – name: Nature Publishing Group |
SSID | ssj0005871 |
Score | 1.6457384 |
Snippet | Certain newly established Epstein‐Barr virus‐containing Burkitt's lymphoma cell lines do not express the cytotoxic T‐lymphocyte‐detected membrane antigen... Certain newly established Epstein-Barr virus-containing Burkitt's lymphoma cell lines do not express the cytotoxic T-lymphocyte-detected membrane antigen... Certain newly established Epstein-Barr virus-containing Burkitt's lymphoma cell lines do not express the cytotoxic T-lympocyte-detected membrane antigen... |
SourceID | pubmedcentral proquest crossref pubmed pascalfrancis wiley |
SourceType | Open Access Repository Aggregation Database Index Database Publisher |
StartPage | 2599 |
SubjectTerms | Antigens, Surface - genetics Biological and medical sciences Burkitt Lymphoma - immunology Burkitt Lymphoma - microbiology Cell Line Cytotoxicity, Immunologic Epstein-Barr virus Fundamental and applied biological sciences. Psychology Genes, Viral Herpesvirus 4, Human - genetics Humans Microbiology Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains T-Lymphocytes - immunology T-Lymphocytes - microbiology Transcription, Genetic Virology |
Title | Restricted expression of EBV latent genes and T‐lymphocyte‐detected membrane antigen in Burkitt's lymphoma cells |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fj.1460-2075.1986.tb04540.x https://www.ncbi.nlm.nih.gov/pubmed/3023050 https://search.proquest.com/docview/14617881 https://search.proquest.com/docview/77160077 https://pubmed.ncbi.nlm.nih.gov/PMC1167158 |
Volume | 5 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3fa9swEBZtoWwwxtatzOva6WGwJye2JdnR3paQUgoZY7Sjb0a_sobFSmgcaP773sl21rDtYXsL2FLQ3Vn6Pt_5O0I-5LDv5lKaeJpJHvPUmlgbzMKrPAPyozMbSv4nX_KLa355I272iOi-hQlF-0bPen5e9fzsNtRWLivT7-rE-l8nI8wdpGLQ3yf7BWMdRe_qOgaBZYUXKzwdyF9KoyGVmScQGIXoAdnO8bUoKtChGvUhds9J8PP7R-fTs6VagammTY-LP4HQ32spH2PccEidvyDPW3RJPzereEn2nD8ih02_yc0ReTLq2ru9IstvDlt2GECc1N235bCeLqZ0PPxO5wBBfU1_4E5Ilbf0Kp5vwPELs6ldbB2mHmBg5Spg297BLTXKetKZp8P13c9ZXX9c0WZEpShmB1avyfX5-Gp0EbftF2KDRgGKKo1VzkmdqERzYZTOAa8UJnFKc8aMEsyKAjaFjAmllUylSVKlpZpaLiRnx-TAL7x7QyiACmslGNi5nAPHUzblBVcDDuiHsWQQEdYZvVw2Khtlo6ecNewkKdFpJTqtbJ1W3kfkdMc_26G4CXHJI_K-81cJxsW1gkUW6xXOmKKO_t_vKIBHotRRRI4b_24nb-MkIsWO47fXUa979wqEcdDtbsM2Ip9CiPzDSsvxZHgZfr_97789IU9x0qYQ8R05qO_W7hQAVa3P8DgTZ-ExegAjpB0x |
link.rule.ids | 230,315,733,786,790,891,27957,27958,53827,53829 |
linkProvider | National Library of Medicine |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwED-NoWmTEB9j0wKM-QGJp7T5cJKaN1p1KmOdEOqmvUW240K1Jq3WVFr567lzkrLy8TDeIjl25PPPzu9yl98BvIvx3I2F0O44ENzlfqZdpSkKL-MAnR8VZDblf3gRDy752XV0vQVR8y-MTdrXatIqpnmrmHy3uZXzXLebPLH2l2GPYgd-1Gk_gse4X4OkcdKbzI6O9bPspxXud8QvrVEbzIw9hEYStdDdjunDKGnQkR71DtXP8egH_HtvqCdzuUBjjasqF3-joX9mU95nufY1dfoMrpoJVtkpN61lqVr6x2_ajw-2wHN4WhNX9rFqfgFbptiHnaqU5WofdntN5biXMP9qqBqIRjLLzF2daVuw2Zj1u1dsiuy2KNk3OmSZLDI2cqcrxNRMr0rjZoaiGtgxNzk68oXBW0pSDGWTgnWXtzeTsny_YFWPXDIKPCwO4PK0P-oN3Lqyg6vJ2uj9Cp1JY4TypKd4pKWKkQol2jNS8TDUMgqzKMHzJggjqaTwhfZ8qYQcZzwSPDyE7WJWmCNgyFeyTODKGRNzdB9l5vOEyw5HYhWGXseBsFnNdF4JeKSVVHNQOT5eSmhICQ1pjYb0zoHjjYVfd6XzjQvuwEkDhBSNS3NFi8yWCxrRJ4n-f9-RoItKKkoOHFbAWQ9eA9CBZANR63aSAt9sQXxYSfAaDw58sNh7wEzT_rB7Zq9f_fdjT2B3MBqep-efLj6_hj16QJXv-Aa2y9ulOUbeVqq3dpf-BAN4PkA |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB5BUQEJ8WipMFC6ByROTvxY21luJCQqhVQValHFxdpXIGriRI0jNfx6ZtZ2SXgc6M2Sd9fa2c_rb3bG3wC8TnHfTYXQ_igS3Oeh0b7SFIWXaYTOj4qMS_kfHqeHZ_zoPDlfK_Xlkva1GreKybRVjL-73Mr5VLebPLH2ybBHsYMw6bTnZtS-DXfwnY1E46g32R0d52u54xUedsQvvVEX0EwDhEeWtNDlTulwlHToSJN6m2roBPQT_tpX6sFcLtBgo6rSxd-o6J8ZletM132qBo_gazPJKkPlorUsVUv_-E3_8UZWeAwPawLL3lVNnsAtW-zAdlXScrUD93pNBbldmH-2VBVEI6ll9qrOuC3YbMT63S9sgiy3KNk32myZLAw79ScrxNZMr0rrG0vRDew4tVN06AuLTUpSDmXjgnWXlxfjsnyzYFWPqWQUgFg8hbNB_7R36NcVHnxNFkcvWGgjrRUqkIHiiZYqRUqU6cBKxeNYyyQ2SYb7ThQnUkkRCh2EUgk5MjwRPN6DrWJW2GfAkLcYI3D1rE05upHShDzjssORYMVx0PEgblY0n1dCHnkl2RxVDlCQEyJyQkReIyK_8mB_Y_Gvu9I-xwX34KABQ47GpbmiRWbLBY0YklT_v1tk6KqSmpIHexV4rgevQehBtoGq6_skCb55BzHipMFrTHjw1uHvP2aa94fdI3f9_MaPPYC7J-8H-acPxx9fwH0av0p7fAlb5eXS7iN9K9Ur96L-BAHBQMA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Restricted+expression+of+EBV+latent+genes+and+T-lymphocyte-detected+membrane+antigen+in+Burkitt%27s+lymphoma+cells&rft.jtitle=The+EMBO+journal&rft.au=Rowe%2C+D+T&rft.au=Rowe%2C+M&rft.au=Evan%2C+G+I&rft.au=Wallace%2C+L+E&rft.date=1986-10-01&rft.issn=0261-4189&rft.volume=5&rft.issue=10&rft.spage=2599&rft_id=info:doi/10.1002%2Fj.1460-2075.1986.tb04540.x&rft_id=info%3Apmid%2F3023050&rft.externalDocID=3023050 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0261-4189&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0261-4189&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0261-4189&client=summon |