Mouse models for abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious...

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Published inBritish journal of pharmacology Vol. 179; no. 5; pp. 792 - 810
Main Authors Golledge, Jonathan, Krishna, Smriti Murali, Wang, Yutang
Format Journal Article
LanguageEnglish
Published England Blackwell Publishing Ltd 01.03.2022
Subjects
abdominal aortic aneurysm
Animal models
Animals
Aortic Aneurysm, Abdominal - drug therapy
Aortic aneurysms
Aortic Rupture - complications
Aortic Rupture - surgery
Asymptomatic
Cardiovascular diseases
Disease Models, Animal
Humans
Mice
mouse models
pathology
Rupture
Thrombosis
mouse models
abdominal aortic aneurysm
pathology
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Abstract Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non‐coding RNAs and thrombosis in aneurysm pathology. Further well‐designed research in clinically relevant models is expected to be translated into effective AAA drugs. LINKED ARTICLES This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc Innate and adaptive immunity, autophagy, protease‐mediated extracellular matrix remodelling, hydroxyapatite‐mediated microcalcification, epigenetic changes, and intraluminal thrombus are strongly implicated in abdominal aortic aneurysm (AAA). Immune response regulators, autophagy promoting agents, protease inhibitors, siRNA inhibiting hydroxyapatite formation, microRNAs, and coagulation cascade inhibitors have been reported to limit AAA development in mice.
AbstractList Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non‐coding RNAs and thrombosis in aneurysm pathology. Further well‐designed research in clinically relevant models is expected to be translated into effective AAA drugs.LINKED ARTICLESThis article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non-coding RNAs and thrombosis in aneurysm pathology. Further well-designed research in clinically relevant models is expected to be translated into effective AAA drugs. LINKED ARTICLES: This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non-coding RNAs and thrombosis in aneurysm pathology. Further well-designed research in clinically relevant models is expected to be translated into effective AAA drugs. LINKED ARTICLES: This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non-coding RNAs and thrombosis in aneurysm pathology. Further well-designed research in clinically relevant models is expected to be translated into effective AAA drugs. LINKED ARTICLES: This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc.
Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this is only indicated for large asymptomatic, symptomatic or ruptured aneurysms, is not always durable, and is associated with a risk of serious perioperative complications. As a result, patients with small asymptomatic aneurysms or who are otherwise unfit for surgery are treated conservatively, but up to 70% of small aneurysms continue to grow, increasing the risk of rupture. There is thus an urgent need to develop drug therapies effective at slowing AAA growth. This review describes the commonly used mouse models for AAA. Recent research in these models highlights key roles for pathways involved in inflammation and cell turnover in AAA pathogenesis. There is also evidence for long non‐coding RNAs and thrombosis in aneurysm pathology. Further well‐designed research in clinically relevant models is expected to be translated into effective AAA drugs. LINKED ARTICLES This article is part of a themed issue on Preclinical Models for Cardiovascular disease research (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.5/issuetoc Innate and adaptive immunity, autophagy, protease‐mediated extracellular matrix remodelling, hydroxyapatite‐mediated microcalcification, epigenetic changes, and intraluminal thrombus are strongly implicated in abdominal aortic aneurysm (AAA). Immune response regulators, autophagy promoting agents, protease inhibitors, siRNA inhibiting hydroxyapatite formation, microRNAs, and coagulation cascade inhibitors have been reported to limit AAA development in mice.
Author Krishna, Smriti Murali
Golledge, Jonathan
Wang, Yutang
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  fullname: Wang, Yutang
  organization: Federation University Australia
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Cites_doi 10.1161/ATVBAHA.117.309897
10.1159/000447263
10.1042/CS20191020
10.1093/eurheartj/ehw257
10.1016/j.avsg.2020.03.002
10.1161/JAHA.119.014757
10.1016/j.atherosclerosis.2019.08.003
10.1016/j.yjmcc.2019.05.002
10.1073/pnas.1900152116
10.1161/ATVBAHA.115.306497
10.1002/jcp.27517
10.1038/s41598-019-44523-6
10.1016/j.ejvs.2010.08.026
10.1038/sj.bjp.0704331
10.1016/j.jvs.2016.12.110
10.21037/cdt.2019.12.08
10.1161/ATVBAHA.119.312659
10.1016/j.atherosclerosis.2012.09.010
10.1161/ATVBAHA.120.314297
10.1016/j.ejvs.2016.07.004
10.1016/j.atherosclerosis.2011.03.006
10.1111/jcmm.15342
10.1111/bph.14751
10.1016/j.atherosclerosis.2017.03.010
10.1016/j.ajpath.2012.04.015
10.1001/jama.2020.5230
10.1161/CIRCULATIONAHA.116.023789
10.1161/HYPERTENSIONAHA.109.140558
10.1161/01.ATV.0000216119.79008.ac
10.1177/1074248418798631
10.1016/j.tips.2018.10.005
10.1111/joim.12958
10.7326/0003-4819-159-12-201312170-00007
10.1155/2015/413189
10.1161/ATVBAHA.117.309999
10.1196/annals.1383.029
10.1016/j.jvs.2019.08.285
10.1161/ATVBAHA.118.312023
10.1161/ATVBAHA.115.305269
10.1007/s10495-019-01540-0
10.1161/HYPERTENSIONAHA.118.12086
10.1016/j.carpath.2012.07.005
10.4049/jimmunol.1800197
10.1067/mva.2002.123757
10.1161/CIRCRESAHA.108.175976
10.1016/j.ejvs.2018.09.020
10.1016/j.ejvs.2018.03.018
10.1111/j.1749-6632.1999.tb07682.x
10.1159/000504848
10.1186/1471-2164-10-298
10.1161/01.RES.0000016501.56641.83
10.1093/cvr/cvy264
10.1111/bph.14857
10.1161/JAHA.119.014044
10.1161/CIRCULATIONAHA.108.806505
10.1161/ATVBAHA.115.305911
10.1161/CIRCGEN.118.002413
10.1074/jbc.M806239200
10.1016/j.jacc.2017.11.053
10.1177/1526602815601405
10.1016/j.jvs.2016.07.105
10.1016/j.nano.2020.102177
10.1161/CIRCRESAHA.108.173682
10.18632/oncotarget.3848
10.1067/mva.2001.117891
10.1161/ATVBAHA.119.312787
10.1007/s11010-019-03567-y
10.1161/CIRCRESAHA.116.308895
10.1007/s00380-018-1301-7
10.1016/j.jvs.2010.08.013
10.1038/s41569-018-0114-9
10.1016/j.ejvs.2020.03.042
10.1093/cvr/cvu257
10.1161/HYPERTENSIONAHA.114.04934
10.1161/01.ATV.0000245819.32762.cb
10.1089/dna.2018.4552
10.1111/bph.14747
10.1016/S0039-6060(99)70114-5
10.1007/s00330-008-0956-3
10.1172/JCI38136
10.1161/ATVBAHA.116.308534
10.1056/NEJMoa1405778
10.1016/j.gheart.2013.12.009
10.1016/j.yjmcc.2019.03.021
10.1093/eurheartj/ehq171
10.1111/jcmm.14554
10.1161/01.ATV.0000058404.92759.32
10.1161/CIRCIMAGING.119.009889
10.1161/CIRCIMAGING.118.008707
10.1038/nrcardio.2017.23
10.1161/ATVBAHA.118.311969
10.1093/cvr/cvx128
10.1111/bph.14753
10.1007/s11883-016-0567-4
10.1172/JCI7818
10.1016/j.ejvs.2018.01.015
10.1002/bjs.9101
10.1038/s41598-019-49682-0
10.1371/journal.pone.0036724
10.1161/ATVBAHA.110.216580
10.1002/bjs.9824
10.14336/AD.2018.1128
10.1038/s41598-020-59842-2
10.1016/j.ejphar.2019.05.032
10.1001/jama.2019.18928
10.1172/JCI8931
10.1161/ATVBAHA.115.305537
10.1042/CS20190924
10.33549/physiolres.933579
10.1073/pnas.1814409116
10.7150/thno.34463
10.1016/S0741-5214(97)70210-6
10.1371/journal.pone.0227165
10.1148/radiol.2016151407
10.1016/j.jvs.2016.05.090
10.1161/01.ATV.0000254680.71485.92
10.1016/j.cell.2017.07.029
10.1016/j.redox.2019.101185
10.1016/j.jvs.2016.08.003
10.1056/NEJMoa013527
10.1161/CIRCULATIONAHA.119.044803
10.1155/2009/352319
10.1161/ATVBAHA.117.309401
10.5551/jat.E611
10.1016/j.jss.2020.01.028
10.2174/1381612821666150826093318
10.1016/j.ejvs.2016.03.012
10.1001/jamacardio.2020.3524
10.1161/01.ATV.0000085631.76095.64
10.1161/01.ATV.0000118013.72016.ea
10.1161/01.CIR.0000038109.84500.1E
10.1001/jama.287.22.2968
10.1161/JAHA.118.009866
10.1161/JAHA.117.007909
10.1016/j.amjsurg.2018.12.054
10.1016/j.yjmcc.2020.04.008
10.1111/bph.14748
10.3390/ijms160511276
10.1038/s41467-019-13017-4
10.1111/bph.14752
10.1111/j.1365-2567.2005.02157.x
10.1161/CIRCULATIONAHA.107.731398
10.1016/j.atherosclerosis.2013.12.017
10.1161/ATVBAHA.119.314113
10.1152/ajpheart.00300.2019
10.1016/j.yjmcc.2018.03.003
10.1093/eurheartj/ehz856
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PublicationDate_xml – month: 03
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  text: March 2022
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle British journal of pharmacology
PublicationTitleAlternate Br J Pharmacol
PublicationYear 2022
Publisher Blackwell Publishing Ltd
Publisher_xml – name: Blackwell Publishing Ltd
References 2019; 10
2019; 12
2004; 24
2011; 53
2019; 16
2020; 15
2019; 19
2019; 289
2019; 322
2019; 202
2020; 13
2020; 288
2020; 323
2020; 10
2008; 102
2009; 119
2016; 37
2016; 36
2018; 7
2001; 134
2018; 39
2009; 10
2019; 24
2019; 23
2006; 26
2015; 373
2008; 117
2020; 177
2019; 317
2002; 90
2014a; 9
2009; 16
2018; 38
2019; 9
2020; 40
2020; 142
2020; 143
2017; 66
2013; 226
2005; 115
2017; 65
1997; 25
2019; 34
2019a; 176
2012; 181
2019; 39
2019; 38
2013; 100
2016; 18
2016; 281
2019; 460
2017; 135
2019; 42
2019; 41
2000; 105
2018; 118
2015; 65
2015; 2015
2020; 26
2017; 261
2019; 856
2019; 217
2001; 34
1999; 878
2019; 176
2003; 23
2015; 35
2010; 55
2013; 22
2015; 105
2015; 102
2020; 60
2019; 57
2020; 57
1999; 126
2017; 113
2014b; 9
2020; 6
2017; 37
2020; 251
2016; 119
2013; 159
2020; 9
2019; 115
2002; 106
2019; 116
2019; 234
2002; 346
2020; 134
2009; 284
2018; 71
2007; 20
2019b; 176
2007; 27
2015; 6
2015; 16
2019; 73
2011; 217
2008; 18
2002; 35
2011; 31
2016; 53
2017; 170
2016; 52
2011; 32
2010; 120
2006; 1
2018; 67
2009; 26
2014; 233
2017; 14
2020
2020; 72
2015; 22
2002; 287
2015; 21
2011; 41
2019
2020; 116
2015
2018; 56
2019; 130
2012; 7
2019; 133
2019; 132
e_1_2_11_70_1
e_1_2_11_93_1
e_1_2_11_32_1
e_1_2_11_55_1
e_1_2_11_78_1
e_1_2_11_36_1
e_1_2_11_51_1
e_1_2_11_74_1
e_1_2_11_97_1
e_1_2_11_13_1
e_1_2_11_118_1
e_1_2_11_29_1
e_1_2_11_125_1
e_1_2_11_4_1
e_1_2_11_106_1
e_1_2_11_148_1
e_1_2_11_48_1
e_1_2_11_121_1
e_1_2_11_102_1
e_1_2_11_144_1
e_1_2_11_140_1
e_1_2_11_81_1
Chaikof E. L. (e_1_2_11_25_1) 2018; 67
e_1_2_11_20_1
e_1_2_11_66_1
e_1_2_11_47_1
e_1_2_11_89_1
e_1_2_11_24_1
e_1_2_11_62_1
e_1_2_11_129_1
e_1_2_11_8_1
e_1_2_11_43_1
e_1_2_11_17_1
e_1_2_11_117_1
e_1_2_11_136_1
e_1_2_11_159_1
e_1_2_11_59_1
e_1_2_11_113_1
e_1_2_11_132_1
e_1_2_11_155_1
e_1_2_11_151_1
Golledge J. (e_1_2_11_52_1) 2020; 26
e_1_2_11_50_1
e_1_2_11_92_1
e_1_2_11_31_1
e_1_2_11_77_1
e_1_2_11_58_1
Wanhainen A. (e_1_2_11_154_1) 2020; 116
e_1_2_11_119_1
e_1_2_11_35_1
e_1_2_11_73_1
e_1_2_11_12_1
e_1_2_11_54_1
e_1_2_11_96_1
e_1_2_11_103_1
e_1_2_11_126_1
e_1_2_11_149_1
Horimatsu T. (e_1_2_11_60_1) 2019
e_1_2_11_5_1
e_1_2_11_145_1
e_1_2_11_141_1
e_1_2_11_160_1
Cooper H. A. (e_1_2_11_30_1) 2020
e_1_2_11_61_1
e_1_2_11_80_1
e_1_2_11_46_1
e_1_2_11_69_1
e_1_2_11_88_1
e_1_2_11_107_1
Cheuk B. L. (e_1_2_11_28_1) 2007; 20
e_1_2_11_9_1
e_1_2_11_23_1
e_1_2_11_42_1
e_1_2_11_65_1
e_1_2_11_114_1
e_1_2_11_16_1
e_1_2_11_137_1
e_1_2_11_156_1
e_1_2_11_110_1
e_1_2_11_39_1
e_1_2_11_133_1
e_1_2_11_152_1
e_1_2_11_72_1
e_1_2_11_91_1
e_1_2_11_57_1
e_1_2_11_99_1
e_1_2_11_34_1
e_1_2_11_53_1
e_1_2_11_76_1
e_1_2_11_95_1
e_1_2_11_11_1
e_1_2_11_6_1
e_1_2_11_104_1
e_1_2_11_27_1
e_1_2_11_127_1
e_1_2_11_2_1
Liu Q. (e_1_2_11_85_1) 2019; 19
e_1_2_11_100_1
e_1_2_11_146_1
e_1_2_11_123_1
e_1_2_11_142_1
Shao F. (e_1_2_11_128_1) 2019
e_1_2_11_83_1
e_1_2_11_45_1
e_1_2_11_68_1
e_1_2_11_87_1
e_1_2_11_108_1
e_1_2_11_22_1
e_1_2_11_64_1
e_1_2_11_115_1
e_1_2_11_138_1
e_1_2_11_15_1
e_1_2_11_111_1
e_1_2_11_134_1
e_1_2_11_38_1
e_1_2_11_157_1
Gandhi R. (e_1_2_11_41_1) 2019
e_1_2_11_19_1
Filardo G. (e_1_2_11_37_1) 2015
e_1_2_11_153_1
e_1_2_11_130_1
e_1_2_11_94_1
e_1_2_11_71_1
e_1_2_11_90_1
Zhang Z. (e_1_2_11_161_1) 2019; 42
e_1_2_11_10_1
e_1_2_11_56_1
e_1_2_11_79_1
e_1_2_11_14_1
e_1_2_11_98_1
e_1_2_11_33_1
e_1_2_11_75_1
e_1_2_11_7_1
e_1_2_11_105_1
e_1_2_11_147_1
e_1_2_11_26_1
e_1_2_11_3_1
e_1_2_11_49_1
e_1_2_11_101_1
Sampson U. K. (e_1_2_11_122_1) 2014; 9
e_1_2_11_124_1
e_1_2_11_143_1
e_1_2_11_120_1
e_1_2_11_82_1
Liu J. (e_1_2_11_84_1) 2020; 6
e_1_2_11_21_1
e_1_2_11_44_1
e_1_2_11_67_1
e_1_2_11_40_1
e_1_2_11_63_1
e_1_2_11_86_1
e_1_2_11_109_1
e_1_2_11_18_1
e_1_2_11_139_1
e_1_2_11_116_1
e_1_2_11_158_1
e_1_2_11_135_1
e_1_2_11_112_1
e_1_2_11_131_1
e_1_2_11_150_1
References_xml – volume: 9
  start-page: 5558
  year: 2019
  end-page: 5576
  article-title: Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis
  publication-title: Theranostics
– year: 2020
  article-title: A modified murine abdominal aortic aneurysm rupture model using elastase perfusion and angiotensin II infusion
  publication-title: Annals of Vascular Surgery
– volume: 115
  start-page: 262
  year: 2005
  end-page: 270
  article-title: Functional characterization of T cells in abdominal aortic aneurysms
  publication-title: Immunology
– volume: 72
  start-page: 1087
  year: 2020
  end-page: 1096.e1
  article-title: Ex vivo expansion of regulatory T cells from abdominal aortic aneurysm patients inhibits aneurysm in humanized murine model
  publication-title: Journal of Vascular Surgery
– volume: 116
  start-page: 13006
  year: 2019
  article-title: Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 40
  start-page: 1352
  year: 2020
  end-page: 1369
  article-title: Runx2 (runt‐related transcription factor 2)‐mediated microcalcification is a novel pathological characteristic and potential mediator of abdominal aortic aneurysm
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 132
  start-page: 49
  year: 2019
  end-page: 59
  article-title: Smooth muscle‐specific Gsα deletion exaggerates angiotensin II‐induced abdominal aortic aneurysm formation in mice
  publication-title: Journal of Molecular and Cellular Cardiology
– volume: 65
  start-page: 52
  year: 2017
  end-page: 57
  article-title: Late rupture of abdominal aortic aneurysm after endovascular repair
  publication-title: Journal of Vascular Surgery
– volume: 102
  start-page: 1368
  year: 2008
  article-title: Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
  publication-title: Circulation Research
– volume: 10
  start-page: 3231
  year: 2020
  article-title: Noninvasive imaging of vascular permeability to predict the risk of rupture in abdominal aortic aneurysms using an albumin‐binding probe
  publication-title: Scientific Reports
– volume: 116
  start-page: 8038
  year: 2019
  end-page: 8047
  article-title: Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity
  publication-title: Proceedings of the National Academy of Sciences of the United States of America
– volume: 65
  start-page: 225
  year: 2017
  end-page: 233
  article-title: Challenges and opportunities in limiting abdominal aortic aneurysm growth
  publication-title: Journal of Vascular Surgery
– volume: 40
  start-page: 1559
  year: 2020
  end-page: 1573
  article-title: Excessive EP4 signaling in smooth muscle cells induces abdominal aortic aneurysm by amplifying inflammation
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 56
  start-page: 102
  year: 2018
  end-page: 109
  article-title: Four surgical modifications to the classic elastase perfusion aneurysm model enable haemodynamic alterations and extended elastase perfusion
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 261
  start-page: 78
  year: 2017
  end-page: 89
  article-title: A systematic review investigating the association of microRNAs with human abdominal aortic aneurysms
  publication-title: Atherosclerosis
– volume: 113
  start-page: 1230
  year: 2017
  article-title: Angiotensin II infusion into ApoE mice: A model for aortic dissection rather than abdominal aortic aneurysm?
  publication-title: Cardiovascular Research
– volume: 19
  start-page: 1396
  year: 2019
  end-page: 1402
  article-title: Gambogic acid prevents angiotensin II‐induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF‐κB signaling pathways
  publication-title: Molecular Medicine Reports
– volume: 52
  start-page: 41
  year: 2016
  end-page: 46
  article-title: Editor's choice—High heritability of liability to abdominal aortic aneurysms: A population based twin study
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 67
  start-page: 573
  year: 2018
  end-page: 584
  article-title: Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase‐induced experimental abdominal aortic aneurysms
  publication-title: Journal of Vascular Surgery
– volume: 35
  start-page: 923
  year: 2002
  end-page: 929
  article-title: Doxycycline in patients with abdominal aortic aneurysms and in mice: Comparison of serum levels and effect on aneurysm growth in mice
  publication-title: Journal of Vascular Surgery
– volume: 105
  start-page: 1641
  year: 2000
  end-page: 1649
  article-title: Targeted gene disruption of matrix metalloproteinase‐9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysms
  publication-title: Journal of Clinical Investigation
– volume: 176
  start-page: S21
  year: 2019
  end-page: S141
  article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors
  publication-title: British Journal of Pharmacology
– volume: 27
  start-page: 380
  year: 2007
  end-page: 386
  article-title: Bone marrow transplantation reveals that recipient AT1a receptors are required to initiate angiotensin II‐induced atherosclerosis and aneurysms
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 130
  start-page: 131
  year: 2019
  end-page: 139
  article-title: Smooth muscle‐specific LKB1 deletion exaggerates angiotensin II‐induced abdominal aortic aneurysm in mice
  publication-title: Journal of Molecular and Cellular Cardiology
– volume: 170
  start-page: 605
  year: 2017
  end-page: 635
  article-title: The PI3K pathway in human disease
  publication-title: Cell
– volume: 251
  start-page: 239
  year: 2020
  end-page: 247
  article-title: Single‐photon emission computed tomography imaging using formyl peptide receptor 1 ligand can diagnose aortic aneurysms in a mouse model
  publication-title: Journal of Surgical Research
– volume: 39
  start-page: 212
  year: 2019
  end-page: 223
  article-title: Deficiency of IL12p40 (interleukin 12 p40) promotes Ang II (angiotensin II)‐induced abdominal aortic aneurysm
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 284
  start-page: 1765
  year: 2009
  end-page: 1771
  article-title: Membrane‐type 1 matrix metalloproteinase regulates macrophage‐dependent elastolytic activity and aneurysm formation in vivo
  publication-title: The Journal of Biological Chemistry
– volume: 18
  start-page: 1987
  year: 2008
  end-page: 1994
  article-title: Measurement and determinants of infrarenal aortic thrombus volume
  publication-title: European Radiology
– volume: 9
  year: 2020
  article-title: Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice
  publication-title: Journal of the American Heart Association
– volume: 10
  start-page: 107
  year: 2020
  end-page: 123
  article-title: Kallistatin correlates with inflammation in abdominal aortic aneurysm and suppresses its formation in mice
  publication-title: Cardiovascular Diagnosis and Therapy
– volume: 119
  start-page: 2209
  year: 2009
  end-page: 2216
  article-title: Clinical trial of doxycycline for matrix metalloproteinase‐9 inhibition in patients with an abdominal aneurysm: Doxycycline selectively depletes aortic wall neutrophils and cytotoxic T cells
  publication-title: Circulation
– volume: 9
  issue: 171–180
  year: 2014b
  article-title: Global and regional burden of aortic dissection and aneurysms: Mortality trends in 21 world regions, 1990 to 2010
  publication-title: Global Heart
– volume: 13
  year: 2020
  article-title: CCR2 positron emission tomography for the assessment of abdominal aortic aneurysm inflammation and rupture prediction
  publication-title: Circulation. Cardiovascular Imaging
– volume: 42
  start-page: 218
  year: 2019
  end-page: 227
  article-title: Knockdown of lncRNA PVT1 inhibits vascular smooth muscle cell apoptosis and extracellular matrix disruption in a murine abdominal aortic aneurysm model
  publication-title: Molecules and Cells
– volume: 105
  start-page: 1605
  year: 2000
  end-page: 1612
  article-title: Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E‐deficient mice
  publication-title: The Journal of Clinical Investigation
– volume: 35
  start-page: 2032
  year: 2015
  end-page: 2041
  article-title: Platelet inhibitors reduce rupture in a mouse model of established abdominal aortic aneurysm
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 176
  start-page: S297
  year: 2019b
  end-page: S396
  article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes
  publication-title: British Journal of Pharmacology
– volume: 16
  start-page: 11276
  year: 2015
  article-title: Adventitial tertiary lymphoid organs as potential source of microRNA biomarkers for abdominal aortic aneurysm
  publication-title: International Journal of Molecular Sciences
– volume: 16
  start-page: 164
  year: 2009
  end-page: 171
  article-title: Involvement of vascular angiotensin II‐forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II‐infused ApoE‐deficient mice
  publication-title: Journal of Atherosclerosis and Thrombosis
– volume: 105
  start-page: 213
  year: 2015
  end-page: 222
  article-title: Dissecting abdominal aortic aneurysm in Ang II‐infused mice: Suprarenal branch ruptures and apparent luminal dilatation
  publication-title: Cardiovascular Research
– volume: 52
  start-page: 487
  year: 2016
  end-page: 499
  article-title: Animal models used to explore abdominal aortic aneurysms: A systematic review
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 41
  start-page: 2456
  issue: 26
  year: 2019
  end-page: 2468
  article-title: Adipocytes promote interleukin‐18 binding to its receptors during abdominal aortic aneurysm formation in mice
  publication-title: European Heart Journal
– volume: 7
  year: 2012
  article-title: Inhibition of EP4 signaling attenuates aortic aneurysm formation
  publication-title: PLoS ONE
– volume: 176
  start-page: S1
  year: 2019a
  end-page: S20
  article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Other Protein Targets
  publication-title: British Journal of Pharmacology
– volume: 39
  start-page: 1614
  year: 2019
  end-page: 1628
  article-title: SGLT‐2 (sodium–glucose cotransporter 2) inhibition reduces Ang II (angiotensin II)‐induced dissecting abdominal aortic aneurysm in ApoE (apolipoprotein E) knockout mice
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 10
  start-page: 298
  year: 2009
  article-title: Whole genome expression analysis within the angiotensin II‐apolipoprotein E deficient mouse model of abdominal aortic aneurysm
  publication-title: BMC Genomics
– volume: 23
  start-page: 1621
  year: 2003
  end-page: 1626
  article-title: Aortic dissection precedes formation of aneurysms and atherosclerosis in angiotensin II‐infused, apolipoprotein E‐deficient mice
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 2015
  year: 2015
  article-title: Morphological and biomechanical differences in the elastase and AngII apoE rodent models of abdominal aortic aneurysms
  publication-title: BioMed Research International
– volume: 73
  start-page: 547
  year: 2019
  end-page: 560
  article-title: Caloric restriction exacerbates angiotensin II‐induced abdominal aortic aneurysm in the absence of p53
  publication-title: Hypertension
– volume: 120
  start-page: 422
  year: 2010
  end-page: 432
  article-title: TGF‐β activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II‐infused mice
  publication-title: The Journal of Clinical Investigation
– volume: 100
  start-page: 863
  year: 2013
  end-page: 872
  article-title: Systematic review and meta‐analysis of the early and late outcomes of open and endovascular repair of abdominal aortic aneurysm
  publication-title: The British Journal of Surgery
– volume: 56
  start-page: 130
  year: 2018
  end-page: 135
  article-title: The relationship between serum interleukin‐1α and asymptomatic infrarenal abdominal aortic aneurysm size, morphology, and growth rates
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 1
  start-page: 59
  issue: 085
  year: 2006
  end-page: 73
  article-title: Pathophysiology of abdominal aortic aneurysms: Insights from the elastase‐induced model in mice with different genetic backgrounds
  publication-title: Annals of the New York Academy of Sciences
– volume: 23
  start-page: 483
  year: 2003
  end-page: 488
  article-title: Differential effects of doxycycline, a broad‐spectrum matrix metalloproteinase inhibitor, on angiotensin II‐induced atherosclerosis and abdominal aortic aneurysms
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 233
  start-page: 211
  year: 2014
  end-page: 218
  article-title: Differential gene expression in the proximal neck of human abdominal aortic aneurysm
  publication-title: Atherosclerosis
– volume: 31
  start-page: 261
  year: 2011
  end-page: 269
  article-title: Deletion of EP4 on bone marrow‐derived cells enhances inflammation and angiotensin II‐induced abdominal aortic aneurysm formation
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 176
  start-page: S397
  year: 2019b
  end-page: S493
  article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters
  publication-title: British Journal of Pharmacology
– volume: 12
  year: 2019
  article-title: Interleukin‐6 receptor signaling and abdominal aortic aneurysm growth rates
  publication-title: Circulation: Genomic and Precision Medicine
– volume: 57
  start-page: 8
  year: 2019
  end-page: 93
  article-title: Editor's choice—European Society for Vascular Surgery (ESVS) 2019 clinical practice guidelines on the management of abdominal aorto‐iliac artery aneurysms
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 6
  start-page: 12984
  year: 2015
  end-page: 12996
  article-title: Differential gene expression in human abdominal aortic aneurysm and aortic occlusive disease
  publication-title: Oncotarget
– volume: 53
  start-page: 28
  year: 2011
  end-page: 35
  article-title: Thrombus volume is associated with cardiovascular events and aneurysm growth in patients who have abdominal aortic aneurysms
  publication-title: Journal of Vascular Surgery
– volume: 38
  start-page: 597
  year: 2019
  end-page: 606
  article-title: Mitochondrial dysfunction in atherosclerosis
  publication-title: DNA and Cell Biology
– volume: 9
  year: 2019
  article-title: Pharmacological inhibition of Notch signaling regresses pre‐established abdominal aortic aneurysm
  publication-title: Science Reporter
– volume: 322
  start-page: 2211
  year: 2019
  end-page: 2218
  article-title: Screening for abdominal aortic aneurysm: US Preventive Services Task Force recommendation statement
  publication-title: JAMA
– volume: 12
  year: 2019
  article-title: Concurrent molecular magnetic resonance imaging of inflammatory activity and extracellular matrix degradation for the prediction of aneurysm rupture
  publication-title: Circulation. Cardiovascular Imaging
– volume: 37
  start-page: 401
  year: 2017
  end-page: 410
  article-title: Translational relevance and recent advances of animal models of abdominal aortic aneurysm
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 37
  start-page: 3213
  year: 2016
  end-page: 3221
  article-title: An evaluation of the effect of an angiotensin‐converting enzyme inhibitor on the growth rate of small abdominal aortic aneurysms: A randomized placebo‐controlled trial (AARDVARK)
  publication-title: European Heart Journal
– volume: 176
  start-page: S247
  year: 2019a
  end-page: S296
  article-title: THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Catalytic receptors
  publication-title: British Journal of Pharmacology
– volume: 217
  start-page: 57
  year: 2011
  end-page: 63
  article-title: Current status of medical management for abdominal aortic aneurysm
  publication-title: Atherosclerosis
– volume: 37
  start-page: 2171
  year: 2017
  end-page: 2181
  article-title: TGFβ (transforming growth factor‐β) blockade induces a human‐like disease in a nondissecting mouse model of abdominal aortic aneurysm
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 39
  start-page: 446
  year: 2019
  end-page: 458
  article-title: IL (interleukin)‐33 suppresses abdominal aortic aneurysm by enhancing regulatory T‐cell expansion and activity
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 53
  start-page: 49
  year: 2016
  end-page: 57
  article-title: Extra‐ and intraluminal elastase induce morphologically distinct abdominal aortic aneurysms in mice and thus represent specific subtypes of human disease
  publication-title: Journal of Vascular Research
– volume: 856
  year: 2019
  article-title: ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II‐induced abdominal aortic aneurysm in apolipoprotein E‐deficient mice
  publication-title: European Journal of Pharmacology
– volume: 25
  start-page: 810
  year: 1997
  end-page: 815
  article-title: Prostaglandin E synthesis and cyclooxygenase expression in abdominal aortic aneurysms
  publication-title: Journal of Vascular Surgery
– volume: 134
  start-page: 1049
  year: 2020
  end-page: 1061
  article-title: Factor XII blockade inhibits aortic dilatation in angiotensin II‐infused apolipoprotein E‐deficient mice
  publication-title: Clinical Science (London, England)
– volume: 106
  start-page: 2503
  year: 2002
  end-page: 2509
  article-title: Inactivation of the lysyl oxidase gene leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice
  publication-title: Circulation
– volume: 26
  start-page: 181
  year: 2009
  end-page: 188
  article-title: A systematic review of studies examining inflammation associated cytokines in human abdominal aortic aneurysm samples
  publication-title: Disease Markers
– volume: 126
  start-page: 624
  year: 1999
  end-page: 627
  article-title: Differential expression of prostaglandin E and interleukin‐6 in occlusive and aneurysmal aortic disease
  publication-title: Surgery
– volume: 24
  start-page: 101185
  year: 2019
  article-title: Knockout of dihydrofolate reductase in mice induces hypertension and abdominal aortic aneurysm via mitochondrial dysfunction
  publication-title: Redox Biology
– year: 2015
  article-title: Surgery for small asymptomatic abdominal aortic aneurysms
  publication-title: Cochrane Database of Systematic Reviews
– volume: 38
  start-page: 843
  year: 2018
  end-page: 853
  article-title: Novel role of IL (interleukin)‐1β in neutrophil extracellular trap formation and abdominal aortic aneurysms
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 18
  start-page: 15
  year: 2016
  article-title: Epigenetics and peripheral artery disease
  publication-title: Current Atherosclerosis Reports
– volume: 133
  start-page: 2203
  year: 2019
  end-page: 2215
  article-title: Depletion of CD11c dendritic cells in apolipoprotein E‐deficient mice limits angiotensin II‐induced abdominal aortic aneurysm formation and growth
  publication-title: Clinical Science (London, England)
– volume: 60
  start-page: 254
  year: 2020
  end-page: 263
  article-title: Inhibition of phosphatidylinositol 3‐kinase γ by IPI‐549 attenuates abdominal aortic aneurysm formation in mice
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 7
  year: 2018
  article-title: In vivo molecular characterization of abdominal aortic aneurysms using fibrin‐specific magnetic resonance imaging
  publication-title: Journal of the American Heart Association
– volume: 20
  start-page: 391
  year: 2007
  end-page: 395
  article-title: Differential secretion of prostaglandin E , thromboxane A and interleukin‐6 in intact and ruptured abdominal aortic aneurysms
  publication-title: International Journal of Molecular Medicine
– volume: 281
  start-page: 772
  year: 2016
  end-page: 781
  article-title: Assessing the stability of aortic aneurysms with pulse wave imaging
  publication-title: Radiology
– volume: 24
  start-page: 385
  year: 2019
  end-page: 394
  article-title: Modulation of CD95‐mediated signaling by post‐translational modifications: Towards understanding CD95 signaling networks
  publication-title: Apoptosis
– year: 2019
  article-title: B cell‐derived anti‐beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia‐aggravated abdominal aortic aneurysm
  publication-title: Cardiovascular Research
– volume: 102
  start-page: 894
  year: 2015
  end-page: 901
  article-title: Randomized clinical trial of mast cell inhibition in patients with a medium‐sized abdominal aortic aneurysm
  publication-title: The British Journal of Surgery
– volume: 14
  start-page: 342
  year: 2017
  end-page: 360
  article-title: Sarcoplasmic reticulum–mitochondria communication in cardiovascular pathophysiology
  publication-title: Nature Reviews. Cardiology
– volume: 26
  year: 2020
  article-title: Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: A randomized clinical trial
  publication-title: JAMA Cardiol
– volume: 10
  start-page: 699
  year: 2019
  end-page: 710
  article-title: IgE aggravates the senescence of smooth muscle cells in abdominal aortic aneurysm by upregulating LincRNA‐p21
  publication-title: Aging and Disease
– volume: 26
  year: 2020
  article-title: Evaluation of a smart activatable MRI nanoprobe to target matrix metalloproteinases in the early‐stages of abdominal aortic aneurysms
  publication-title: Nanomedicine
– volume: 323
  start-page: 2029
  year: 2020
  end-page: 2038
  article-title: Effect of doxycycline on aneurysm growth among patients with small infrarenal abdominal aortic aneurysms: A randomized clinical trial
  publication-title: JAMA
– volume: 9
  start-page: 8065
  year: 2019
  article-title: CTLA‐4 protects against angiotensin II‐induced abdominal aortic aneurysm formation in mice
  publication-title: Scientific Reports
– volume: 317
  start-page: H981
  year: 2019
  end-page: H990
  article-title: High‐frequency murine ultrasound provides enhanced metrics of BAPN‐induced AAA growth
  publication-title: American Journal of Physiology—Heart and Circulatory Physiology
– volume: 878
  start-page: 159
  year: 1999
  end-page: 178
  article-title: MMP inhibition in abdominal aortic aneurysms: Rationale for a prospective randomized clinical trial
  publication-title: Annals of the New York Academy of Sciences
– volume: 24
  start-page: 429
  year: 2004
  end-page: 434
  article-title: Mouse models of abdominal aortic aneurysms
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 373
  start-page: 328
  year: 2015
  end-page: 338
  article-title: Long‐term outcomes of abdominal aortic aneurysm in the medicare population
  publication-title: The New England Journal of Medicine
– year: 2020
  article-title: Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm
  publication-title: Cardiovascular Research
– volume: 143
  start-page: 1
  year: 2020
  end-page: 14
  article-title: MiR‐144‐5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage‐associated inflammation: Suppression of TLR2 and OLR1
  publication-title: Journal of Molecular and Cellular Cardiology
– volume: 118
  start-page: 26
  year: 2018
  end-page: 35
  article-title: Necroptosis in cardiovascular disease—A new therapeutic target
  publication-title: Journal of Molecular and Cellular Cardiology
– volume: 135
  start-page: 379
  year: 2017
  end-page: 391
  article-title: Female mice with an XY sex chromosome complement develop severe angiotensin II‐induced abdominal aortic aneurysms
  publication-title: Circulation
– volume: 117
  start-page: 1302
  year: 2008
  article-title: Microsomal prostaglandin E synthase‐1 deletion suppresses oxidative stress and angiotensin II‐induced abdominal aortic aneurysm formation
  publication-title: Circulation
– volume: 66
  start-page: 899
  year: 2017
  end-page: 915
  article-title: Animal models in the research of abdominal aortic aneurysms development
  publication-title: Physiological Research
– year: 2020
  article-title: Randomised‐controlled trial testing the efficacy of telmisartan to slow growth of small abdominal aortic aneurysms
  publication-title: JAMA Cardiology
– volume: 26
  start-page: 1137
  year: 2006
  end-page: 1143
  article-title: Selective cyclooxygenase‐2 inhibition with celecoxib decreases angiotensin II‐induced abdominal aortic aneurysm formation in mice
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 34
  start-page: 875
  year: 2019
  end-page: 882
  article-title: Chemokine (C–X–C motif) receptor 2 blockade by SB265610 inhibited angiotensin II‐induced abdominal aortic aneurysm in Apo E mice
  publication-title: Heart and Vessels
– volume: 7
  year: 2018
  article-title: Randomized placebo‐controlled trial assessing the effect of 24‐week fenofibrate therapy on circulating markers of abdominal aortic aneurysm: Outcomes from the FAME‐2 trial
  publication-title: Journal of the American Heart Association
– volume: 202
  start-page: 1176
  year: 2019
  end-page: 1185
  article-title: Ablation and inhibition of the immunoproteasome catalytic subunit LMP7 attenuate experimental abdominal aortic aneurysm formation in mice
  publication-title: Journal of Immunology
– volume: 16
  start-page: 225
  year: 2019
  end-page: 242
  article-title: Abdominal aortic aneurysm: Update on pathogenesis and medical treatments
  publication-title: Nature Reviews. Cardiology
– volume: 34
  start-page: 606
  year: 2001
  end-page: 610
  article-title: Use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: A randomized, double‐blind, placebo‐controlled pilot study
  publication-title: Journal of Vascular Surgery
– volume: 35
  start-page: 1746
  year: 2015
  end-page: 1755
  article-title: Inflammatory cell phenotypes in AAAs: Their role and potential as targets for therapy
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 39
  start-page: 1351
  year: 2019
  end-page: 1368
  article-title: Role of vascular smooth muscle cell phenotypic switching and calcification in aortic aneurysm formation
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 288
  start-page: 6
  year: 2020
  end-page: 22
  article-title: Lack of an effective drug therapy for abdominal aortic aneurysm
  publication-title: Journal of Internal Medicine
– volume: 234
  start-page: 7560
  year: 2019
  end-page: 7568
  article-title: Licochalcone A attenuates abdominal aortic aneurysm induced by angiotensin II via regulating the miR‐181b/SIRT1/HO‐1 signaling
  publication-title: Journal of Cellular Physiology
– volume: 66
  start-page: 232
  year: 2017
  end-page: 242
  article-title: A novel chronic advanced stage abdominal aortic aneurysm murine model
  publication-title: Journal of Vascular Surgery
– volume: 71
  start-page: 513
  year: 2018
  end-page: 523
  article-title: F–sodium fluoride uptake in abdominal aortic aneurysms: The SoFIA 3 study
  publication-title: Journal of the American College of Cardiology
– volume: 115
  start-page: 807
  year: 2019
  end-page: 818
  article-title: CD95‐ligand contributes to abdominal aortic aneurysm progression by modulating inflammation
  publication-title: Cardiovascular Research
– volume: 23
  start-page: 6766
  year: 2019
  end-page: 6774
  article-title: Regulatory T cells protected against abdominal aortic aneurysm by suppression of the COX‐2 expression
  publication-title: Journal of Cellular and Molecular Medicine
– volume: 6
  start-page: 1099
  year: 2020
  article-title: Hypercholesterolemia accelerates both the initiation and progression of angiotensin II‐induced abdominal aortic aneurysms
  publication-title: Annals Vascular Medicine Research
– volume: 9
  start-page: 159
  year: 2014a
  end-page: 170
  article-title: Estimation of global and regional incidence and prevalence of abdominal aortic aneurysms 1990 to 2010
  publication-title: Global Heart
– volume: 226
  start-page: 29
  year: 2013
  end-page: 39
  article-title: The calcium chloride‐induced rodent model of abdominal aortic aneurysm
  publication-title: Atherosclerosis
– volume: 10
  start-page: 5046
  year: 2019
  article-title: IL‐27 receptor‐regulated stress myelopoiesis drives abdominal aortic aneurysm development
  publication-title: Nature Communications
– volume: 39
  start-page: 1064
  year: 2018
  end-page: 1076
  article-title: Targeting autophagy in aging and aging‐related cardiovascular diseases
  publication-title: Trends in Pharmacological Sciences
– volume: 119
  start-page: 1076
  year: 2016
  end-page: 1088
  article-title: Age‐associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm
  publication-title: Circulation Research
– volume: 22
  start-page: 734
  year: 2015
  end-page: 744
  article-title: Late rupture of abdominal aortic aneurysm after previous endovascular repair: A systematic review and meta‐analysis
  publication-title: Journal of Endovascular Therapy
– volume: 37
  start-page: 2102
  year: 2017
  end-page: 2113
  article-title: TGF‐β (transforming growth factor‐β) signaling protects the thoracic and abdominal aorta from angiotensin II‐induced pathology by distinct mechanisms
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– year: 2019
  article-title: Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: Role of NAD /nicotinamide
  publication-title: Cardiovascular Research
– volume: 15
  year: 2020
  article-title: Nanoparticle‐based targeted delivery of pentagalloyl glucose reverses elastase‐induced abdominal aortic aneurysm and restores aorta to the healthy state in mice
  publication-title: PLoS ONE
– volume: 22
  start-page: 126
  year: 2013
  end-page: 132
  article-title: Transforming growth factor‐β and abdominal aortic aneurysms
  publication-title: Cardiovascular Pathology
– volume: 460
  start-page: 29
  year: 2019
  end-page: 36
  article-title: Endothelial retinoblastoma protein reduces abdominal aortic aneurysm development via promoting DHFR/NO pathway‐mediated vasoprotection
  publication-title: Molecular and Cellular Biochemistry
– volume: 36
  start-page: 69
  year: 2016
  end-page: 77
  article-title: Allergic lung inflammation aggravates angiotensin II‐induced abdominal aortic aneurysms in mice
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 9
  issue: 8
  year: 2020
  article-title: Spermidine suppresses development of experimental abdominal aortic aneurysms
  publication-title: Journal of the American Heart Association
– volume: 67
  issue: 2–77
  year: 2018
  article-title: The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm
  publication-title: Journal of Vascular Surgery
– volume: 142
  start-page: 483
  year: 2020
  end-page: 498
  article-title: Cyclodextrin prevents abdominal aortic aneurysm via activation of vascular smooth muscle cell TFEB
  publication-title: Circulation
– volume: 57
  start-page: 58
  year: 2020
  end-page: 64
  article-title: Ulinastatin inhibits the formation and progression of experimental abdominal aortic aneurysms
  publication-title: Journal of Vascular Research
– volume: 346
  start-page: 1445
  year: 2002
  end-page: 1452
  article-title: Long‐term outcomes of immediate repair compared with surveillance of small abdominal aortic aneurysms
  publication-title: The New England Journal of Medicine
– volume: 159
  start-page: 815
  year: 2013
  end-page: 823
  article-title: Doxycycline for stabilization of abdominal aortic aneurysms: A randomized trial
  publication-title: Annals of Internal Medicine
– volume: 21
  start-page: 4035
  year: 2015
  end-page: 4048
  article-title: Angiotensin II and abdominal aortic aneurysms: An update
  publication-title: Current Pharmaceutical Design
– volume: 90
  start-page: 897
  year: 2002
  end-page: 903
  article-title: Reduced atherosclerotic plaque but enhanced aneurysm formation in mice with inactivation of the tissue inhibitor of metalloproteinase‐1 ( ) gene
  publication-title: Circulation Research
– volume: 287
  start-page: 2968
  year: 2002
  end-page: 2972
  article-title: Rupture rate of large abdominal aortic aneurysms in patients refusing or unfit for elective repair
  publication-title: JAMA
– volume: 26
  start-page: 2605
  year: 2006
  end-page: 2613
  article-title: Abdominal aortic aneurysm: Pathogenesis and implications for management
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 32
  start-page: 354
  year: 2011
  end-page: 364
  article-title: Evaluation of the diagnostic and prognostic value of plasma ‐dimer for abdominal aortic aneurysm
  publication-title: European Heart Journal
– volume: 217
  start-page: 943
  year: 2019
  end-page: 947
  article-title: Predictors of perioperative morbidity and mortality in open abdominal aortic aneurysm repair
  publication-title: American Journal of Surgery
– volume: 289
  start-page: 14
  year: 2019
  end-page: 20
  article-title: Deletion of interleukin‐18 attenuates abdominal aortic aneurysm formation
  publication-title: Atherosclerosis
– year: 2020
  article-title: AT2R agonist NP‐6A4 mitigates aortic stiffness and proteolytic activity in mouse model of aneurysm
  publication-title: Journal of Cellular and Molecular Medicine
– volume: 116
  start-page: 450
  year: 2020
  end-page: 456
  article-title: The effect of ticagrelor on growth of small abdominal aortic aneurysms—A randomized controlled trial
  publication-title: Cardiovascular Research
– volume: 55
  start-page: 1267
  year: 2010
  end-page: 1274
  article-title: Pharmacologically induced thoracic and abdominal aortic aneurysms in mice
  publication-title: Hypertension
– volume: 24
  start-page: 172
  year: 2019
  end-page: 181
  article-title: Comparison of efficacy between ramipril and carvedilol on limiting the expansion of abdominal aortic aneurysm in mouse model
  publication-title: Journal of Cardiovascular Pharmacology and Therapeutics
– volume: 41
  start-page: 13
  year: 2011
  end-page: 25
  article-title: Comparison of surveillance versus aortic endografting for small aneurysm repair (CAESAR): Results from a randomised trial
  publication-title: European Journal of Vascular and Endovascular Surgery
– volume: 36
  start-page: 570
  year: 2016
  end-page: 578
  article-title: Asthma associates with human abdominal aortic aneurysm and rupture
  publication-title: Arteriosclerosis, Thrombosis, and Vascular Biology
– volume: 102
  start-page: 1529
  year: 2008
  end-page: 1538
  article-title: Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration
  publication-title: Circulation Research
– year: 2019
  article-title: Cell proliferation detected using [ F]FLT PET/CT as an early marker of abdominal aortic aneurysm
  publication-title: Journal of Nuclear Cardiology
– volume: 65
  start-page: 889
  year: 2015
  end-page: 895
  article-title: Foxp3 regulatory T cells play a protective role in angiotensin II‐induced aortic aneurysm formation in mice
  publication-title: Hypertension
– volume: 177
  start-page: 204
  year: 2020
  end-page: 216
  article-title: Mechanisms underlying the inhibitory effects of probucol on elastase‐induced abdominal aortic aneurysm in mice
  publication-title: British Journal of Pharmacology
– volume: 181
  start-page: 706
  year: 2012
  end-page: 718
  article-title: Fenofibrate increases high‐density lipoprotein and sphingosine 1 phosphate concentrations limiting abdominal aortic aneurysm progression in a mouse model
  publication-title: The American Journal of Pathology
– volume: 134
  start-page: 865
  year: 2001
  end-page: 870
  article-title: Antagonism of AT2 receptors augments Angiotensin II‐induced abdominal aortic aneurysms and atherosclerosis
  publication-title: British Journal of Pharmacology
– ident: e_1_2_11_95_1
  doi: 10.1161/ATVBAHA.117.309897
– ident: e_1_2_11_21_1
  doi: 10.1159/000447263
– ident: e_1_2_11_97_1
  doi: 10.1042/CS20191020
– ident: e_1_2_11_15_1
  doi: 10.1093/eurheartj/ehw257
– ident: e_1_2_11_160_1
  doi: 10.1016/j.avsg.2020.03.002
– ident: e_1_2_11_87_1
  doi: 10.1161/JAHA.119.014757
– volume: 116
  start-page: 450
  year: 2020
  ident: e_1_2_11_154_1
  article-title: The effect of ticagrelor on growth of small abdominal aortic aneurysms—A randomized controlled trial
  publication-title: Cardiovascular Research
– ident: e_1_2_11_137_1
  doi: 10.1016/j.atherosclerosis.2019.08.003
– ident: e_1_2_11_114_1
  doi: 10.1016/j.yjmcc.2019.05.002
– ident: e_1_2_11_149_1
  doi: 10.1073/pnas.1900152116
– ident: e_1_2_11_82_1
  doi: 10.1161/ATVBAHA.115.306497
– ident: e_1_2_11_61_1
  doi: 10.1002/jcp.27517
– ident: e_1_2_11_11_1
  doi: 10.1038/s41598-019-44523-6
– ident: e_1_2_11_22_1
  doi: 10.1016/j.ejvs.2010.08.026
– ident: e_1_2_11_33_1
  doi: 10.1038/sj.bjp.0704331
– ident: e_1_2_11_156_1
  doi: 10.1016/j.jvs.2016.12.110
– ident: e_1_2_11_57_1
  doi: 10.21037/cdt.2019.12.08
– ident: e_1_2_11_101_1
  doi: 10.1161/ATVBAHA.119.312659
– ident: e_1_2_11_151_1
  doi: 10.1016/j.atherosclerosis.2012.09.010
– ident: e_1_2_11_58_1
  doi: 10.1161/ATVBAHA.120.314297
– ident: e_1_2_11_92_1
  doi: 10.1016/j.ejvs.2016.07.004
– ident: e_1_2_11_47_1
  doi: 10.1016/j.atherosclerosis.2011.03.006
– ident: e_1_2_11_131_1
  doi: 10.1111/jcmm.15342
– ident: e_1_2_11_5_1
  doi: 10.1111/bph.14751
– ident: e_1_2_11_63_1
  doi: 10.1016/j.atherosclerosis.2017.03.010
– ident: e_1_2_11_68_1
  doi: 10.1016/j.ajpath.2012.04.015
– ident: e_1_2_11_14_1
  doi: 10.1001/jama.2020.5230
– ident: e_1_2_11_10_1
  doi: 10.1161/CIRCULATIONAHA.116.023789
– ident: e_1_2_11_65_1
  doi: 10.1161/HYPERTENSIONAHA.109.140558
– ident: e_1_2_11_66_1
  doi: 10.1161/01.ATV.0000216119.79008.ac
– ident: e_1_2_11_104_1
  doi: 10.1177/1074248418798631
– ident: e_1_2_11_117_1
  doi: 10.1016/j.tips.2018.10.005
– ident: e_1_2_11_49_1
  doi: 10.1111/joim.12958
– ident: e_1_2_11_96_1
  doi: 10.7326/0003-4819-159-12-201312170-00007
– ident: e_1_2_11_110_1
  doi: 10.1155/2015/413189
– ident: e_1_2_11_70_1
  doi: 10.1161/ATVBAHA.117.309999
– ident: e_1_2_11_141_1
  doi: 10.1196/annals.1383.029
– ident: e_1_2_11_138_1
  doi: 10.1016/j.jvs.2019.08.285
– ident: e_1_2_11_75_1
  doi: 10.1161/ATVBAHA.118.312023
– ident: e_1_2_11_31_1
  doi: 10.1161/ATVBAHA.115.305269
– ident: e_1_2_11_126_1
  doi: 10.1007/s10495-019-01540-0
– ident: e_1_2_11_42_1
  doi: 10.1161/HYPERTENSIONAHA.118.12086
– ident: e_1_2_11_152_1
  doi: 10.1016/j.carpath.2012.07.005
– ident: e_1_2_11_72_1
  doi: 10.4049/jimmunol.1800197
– ident: e_1_2_11_112_1
  doi: 10.1067/mva.2002.123757
– volume: 9
  start-page: e110
  issue: 171
  year: 2014
  ident: e_1_2_11_122_1
  article-title: Global and regional burden of aortic dissection and aneurysms: Mortality trends in 21 world regions, 1990 to 2010
  publication-title: Global Heart
– ident: e_1_2_11_29_1
  doi: 10.1161/CIRCRESAHA.108.175976
– year: 2019
  ident: e_1_2_11_128_1
  article-title: B cell‐derived anti‐beta 2 glycoprotein I antibody contributes to hyperhomocysteinaemia‐aggravated abdominal aortic aneurysm
  publication-title: Cardiovascular Research
– ident: e_1_2_11_153_1
  doi: 10.1016/j.ejvs.2018.09.020
– ident: e_1_2_11_20_1
  doi: 10.1016/j.ejvs.2018.03.018
– ident: e_1_2_11_140_1
  doi: 10.1111/j.1749-6632.1999.tb07682.x
– year: 2019
  ident: e_1_2_11_60_1
  article-title: Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: Role of NAD+/nicotinamide
  publication-title: Cardiovascular Research
– ident: e_1_2_11_73_1
  doi: 10.1159/000504848
– ident: e_1_2_11_120_1
  doi: 10.1186/1471-2164-10-298
– ident: e_1_2_11_133_1
  doi: 10.1161/01.RES.0000016501.56641.83
– ident: e_1_2_11_88_1
  doi: 10.1093/cvr/cvy264
– ident: e_1_2_11_26_1
  doi: 10.1111/bph.14857
– ident: e_1_2_11_118_1
  doi: 10.1161/JAHA.119.014044
– start-page: CD001835
  year: 2015
  ident: e_1_2_11_37_1
  article-title: Surgery for small asymptomatic abdominal aortic aneurysms
  publication-title: Cochrane Database of Systematic Reviews
– ident: e_1_2_11_78_1
  doi: 10.1161/CIRCULATIONAHA.108.806505
– ident: e_1_2_11_83_1
  doi: 10.1161/ATVBAHA.115.305911
– ident: e_1_2_11_103_1
  doi: 10.1161/CIRCGEN.118.002413
– ident: e_1_2_11_155_1
  doi: 10.1074/jbc.M806239200
– ident: e_1_2_11_39_1
  doi: 10.1016/j.jacc.2017.11.053
– ident: e_1_2_11_13_1
  doi: 10.1177/1526602815601405
– ident: e_1_2_11_90_1
  doi: 10.1016/j.jvs.2016.07.105
– ident: e_1_2_11_157_1
  doi: 10.1016/j.nano.2020.102177
– year: 2019
  ident: e_1_2_11_41_1
  article-title: Cell proliferation detected using [18F]FLT PET/CT as an early marker of abdominal aortic aneurysm
  publication-title: Journal of Nuclear Cardiology
– ident: e_1_2_11_145_1
  doi: 10.1161/CIRCRESAHA.108.173682
– ident: e_1_2_11_16_1
  doi: 10.18632/oncotarget.3848
– ident: e_1_2_11_98_1
  doi: 10.1067/mva.2001.117891
– ident: e_1_2_11_109_1
  doi: 10.1161/ATVBAHA.119.312787
– volume: 42
  start-page: 218
  year: 2019
  ident: e_1_2_11_161_1
  article-title: Knockdown of lncRNA PVT1 inhibits vascular smooth muscle cell apoptosis and extracellular matrix disruption in a murine abdominal aortic aneurysm model
  publication-title: Molecules and Cells
– ident: e_1_2_11_23_1
  doi: 10.1007/s11010-019-03567-y
– ident: e_1_2_11_27_1
  doi: 10.1161/CIRCRESAHA.116.308895
– ident: e_1_2_11_100_1
  doi: 10.1007/s00380-018-1301-7
– ident: e_1_2_11_105_1
  doi: 10.1016/j.jvs.2010.08.013
– ident: e_1_2_11_44_1
  doi: 10.1038/s41569-018-0114-9
– ident: e_1_2_11_86_1
  doi: 10.1016/j.ejvs.2020.03.042
– ident: e_1_2_11_144_1
  doi: 10.1093/cvr/cvu257
– ident: e_1_2_11_158_1
  doi: 10.1161/HYPERTENSIONAHA.114.04934
– ident: e_1_2_11_46_1
  doi: 10.1161/01.ATV.0000245819.32762.cb
– ident: e_1_2_11_107_1
  doi: 10.1089/dna.2018.4552
– ident: e_1_2_11_8_1
  doi: 10.1111/bph.14747
– ident: e_1_2_11_116_1
  doi: 10.1016/S0039-6060(99)70114-5
– ident: e_1_2_11_53_1
  doi: 10.1007/s00330-008-0956-3
– ident: e_1_2_11_150_1
  doi: 10.1172/JCI38136
– ident: e_1_2_11_125_1
  doi: 10.1161/ATVBAHA.116.308534
– ident: e_1_2_11_124_1
  doi: 10.1056/NEJMoa1405778
– ident: e_1_2_11_121_1
  doi: 10.1016/j.gheart.2013.12.009
– ident: e_1_2_11_74_1
  doi: 10.1016/j.yjmcc.2019.03.021
– ident: e_1_2_11_50_1
  doi: 10.1093/eurheartj/ehq171
– ident: e_1_2_11_80_1
  doi: 10.1111/jcmm.14554
– ident: e_1_2_11_94_1
  doi: 10.1161/01.ATV.0000058404.92759.32
– ident: e_1_2_11_36_1
  doi: 10.1161/CIRCIMAGING.119.009889
– ident: e_1_2_11_19_1
  doi: 10.1161/CIRCIMAGING.118.008707
– ident: e_1_2_11_89_1
  doi: 10.1038/nrcardio.2017.23
– ident: e_1_2_11_129_1
  doi: 10.1161/ATVBAHA.118.311969
– ident: e_1_2_11_143_1
  doi: 10.1093/cvr/cvx128
– ident: e_1_2_11_7_1
  doi: 10.1111/bph.14753
– ident: e_1_2_11_48_1
  doi: 10.1007/s11883-016-0567-4
– ident: e_1_2_11_34_1
  doi: 10.1172/JCI7818
– volume: 19
  start-page: 1396
  year: 2019
  ident: e_1_2_11_85_1
  article-title: Gambogic acid prevents angiotensin II‐induced abdominal aortic aneurysm through inflammatory and oxidative stress dependent targeting the PI3K/Akt/mTOR and NF‐κB signaling pathways
  publication-title: Molecular Medicine Reports
– ident: e_1_2_11_3_1
  doi: 10.1016/j.ejvs.2018.01.015
– ident: e_1_2_11_136_1
  doi: 10.1002/bjs.9101
– ident: e_1_2_11_130_1
  doi: 10.1038/s41598-019-49682-0
– volume: 20
  start-page: 391
  year: 2007
  ident: e_1_2_11_28_1
  article-title: Differential secretion of prostaglandin E2, thromboxane A2 and interleukin‐6 in intact and ruptured abdominal aortic aneurysms
  publication-title: International Journal of Molecular Medicine
– ident: e_1_2_11_159_1
  doi: 10.1371/journal.pone.0036724
– ident: e_1_2_11_139_1
  doi: 10.1161/ATVBAHA.110.216580
– ident: e_1_2_11_134_1
  doi: 10.1002/bjs.9824
– ident: e_1_2_11_54_1
  doi: 10.14336/AD.2018.1128
– ident: e_1_2_11_2_1
  doi: 10.1038/s41598-020-59842-2
– ident: e_1_2_11_142_1
  doi: 10.1016/j.ejphar.2019.05.032
– ident: e_1_2_11_147_1
  doi: 10.1001/jama.2019.18928
– volume: 67
  start-page: e72
  issue: 2
  year: 2018
  ident: e_1_2_11_25_1
  article-title: The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm
  publication-title: Journal of Vascular Surgery
– ident: e_1_2_11_113_1
  doi: 10.1172/JCI8931
– ident: e_1_2_11_102_1
  doi: 10.1161/ATVBAHA.115.305537
– ident: e_1_2_11_67_1
  doi: 10.1042/CS20190924
– ident: e_1_2_11_106_1
  doi: 10.33549/physiolres.933579
– ident: e_1_2_11_9_1
  doi: 10.1073/pnas.1814409116
– ident: e_1_2_11_56_1
  doi: 10.7150/thno.34463
– ident: e_1_2_11_59_1
  doi: 10.1016/S0741-5214(97)70210-6
– ident: e_1_2_11_35_1
  doi: 10.1371/journal.pone.0227165
– ident: e_1_2_11_99_1
  doi: 10.1148/radiol.2016151407
– ident: e_1_2_11_115_1
  doi: 10.1016/j.jvs.2016.05.090
– ident: e_1_2_11_24_1
  doi: 10.1161/01.ATV.0000254680.71485.92
– ident: e_1_2_11_40_1
  doi: 10.1016/j.cell.2017.07.029
– ident: e_1_2_11_76_1
  doi: 10.1016/j.redox.2019.101185
– ident: e_1_2_11_51_1
  doi: 10.1016/j.jvs.2016.08.003
– ident: e_1_2_11_146_1
  doi: 10.1056/NEJMoa013527
– ident: e_1_2_11_91_1
  doi: 10.1161/CIRCULATIONAHA.119.044803
– ident: e_1_2_11_43_1
  doi: 10.1155/2009/352319
– ident: e_1_2_11_12_1
  doi: 10.1161/ATVBAHA.117.309401
– ident: e_1_2_11_62_1
  doi: 10.5551/jat.E611
– ident: e_1_2_11_127_1
  doi: 10.1016/j.jss.2020.01.028
– ident: e_1_2_11_79_1
  doi: 10.2174/1381612821666150826093318
– ident: e_1_2_11_64_1
  doi: 10.1016/j.ejvs.2016.03.012
– ident: e_1_2_11_45_1
  doi: 10.1001/jamacardio.2020.3524
– ident: e_1_2_11_123_1
  doi: 10.1161/01.ATV.0000085631.76095.64
– ident: e_1_2_11_32_1
  doi: 10.1161/01.ATV.0000118013.72016.ea
– ident: e_1_2_11_93_1
  doi: 10.1161/01.CIR.0000038109.84500.1E
– ident: e_1_2_11_71_1
  doi: 10.1001/jama.287.22.2968
– ident: e_1_2_11_111_1
  doi: 10.1161/JAHA.118.009866
– year: 2020
  ident: e_1_2_11_30_1
  article-title: Targeting mitochondrial fission as a potential therapeutic for abdominal aortic aneurysm
  publication-title: Cardiovascular Research
– volume: 6
  start-page: 1099
  year: 2020
  ident: e_1_2_11_84_1
  article-title: Hypercholesterolemia accelerates both the initiation and progression of angiotensin II‐induced abdominal aortic aneurysms
  publication-title: Annals Vascular Medicine Research
– ident: e_1_2_11_18_1
  doi: 10.1161/JAHA.117.007909
– ident: e_1_2_11_69_1
  doi: 10.1016/j.amjsurg.2018.12.054
– ident: e_1_2_11_132_1
  doi: 10.1016/j.yjmcc.2020.04.008
– volume: 26
  year: 2020
  ident: e_1_2_11_52_1
  article-title: Efficacy of telmisartan to slow growth of small abdominal aortic aneurysms: A randomized clinical trial
  publication-title: JAMA Cardiol
– ident: e_1_2_11_4_1
  doi: 10.1111/bph.14748
– ident: e_1_2_11_135_1
  doi: 10.3390/ijms160511276
– ident: e_1_2_11_108_1
  doi: 10.1038/s41467-019-13017-4
– ident: e_1_2_11_6_1
  doi: 10.1111/bph.14752
– ident: e_1_2_11_38_1
  doi: 10.1111/j.1365-2567.2005.02157.x
– ident: e_1_2_11_148_1
  doi: 10.1161/CIRCULATIONAHA.107.731398
– ident: e_1_2_11_17_1
  doi: 10.1016/j.atherosclerosis.2013.12.017
– ident: e_1_2_11_77_1
  doi: 10.1161/ATVBAHA.119.314113
– ident: e_1_2_11_119_1
  doi: 10.1152/ajpheart.00300.2019
– ident: e_1_2_11_55_1
  doi: 10.1016/j.yjmcc.2018.03.003
– ident: e_1_2_11_81_1
  doi: 10.1093/eurheartj/ehz856
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Snippet Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year. Currently, the only treatment for AAA is surgical repair; however, this...
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SubjectTerms abdominal aortic aneurysm
Animal models
Animals
Aortic Aneurysm, Abdominal - drug therapy
Aortic aneurysms
Aortic Rupture - complications
Aortic Rupture - surgery
Asymptomatic
Cardiovascular diseases
Disease Models, Animal
Humans
Mice
mouse models
pathology
Rupture
Thrombosis
Title Mouse models for abdominal aortic aneurysm
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fbph.15260
https://www.ncbi.nlm.nih.gov/pubmed/32914434
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