Efficacy and Safety of Immunosuppression Withdrawal in Pediatric Liver Transplant Recipients: Moving Toward Personalized Management

• Published in: Hepatology (Baltimore, Md.) Vol. 73; no. 5; pp. 1985 - 2004
• Main Authors: Feng, Sandy, Bucuvalas, John C., Mazariegos, George V., Magee, John C., Sanchez‐Fueyo, Alberto, Spain, Katharine M., Lesniak, Andrew, Kanaparthi, Sai, Perito, Emily, Venkat, Veena L., Burrell, Bryna E., Alonso, Estella M., Bridges, Nancy D., Doo, Edward, Gupta, Nitika A., Himes, Ryan W., Ikle, David, Jackson, Annette M., Lobritto, Steven J., Jose Lozano, Juan, Martinez, Mercedes, Ng, Vicky L., Rand, Elizabeth B., Sherker, Averell H., Sundaram, Shikha S., Turmelle, Yumirle P., Wood‐Trageser, Michele, Demetris, Anthony J.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2021
• Subjects: Alanine; Alanine transaminase; Allografts; Biopsy; Child; Child, Preschool; Corticosteroids; Female; Fibrosis; Graft rejection; Graft Rejection - epidemiology; Graft Rejection - etiology; Hepatology; Histology; Humans; Immunological tolerance; Immunosuppression; Immunosuppressive Agents - administration & dosage; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Infant; Liver transplantation; Liver Transplantation - adverse effects; Liver Transplantation - methods; Liver transplants; Male; Pediatrics; Precision Medicine - methods; Prospective Studies; Safety; Tacrolimus; Withholding Treatment

Background and Aims Tolerance is transplantation’s holy grail, as it denotes allograft health without immunosuppression and its toxicities. Our aim was to determine, among stable long‐term pediatric liver transplant recipients, the efficacy and safety of immunosuppression withdrawal to identify oper...