Imbalanced Osteogenesis and Adipogenesis in Mice Deficient in the Chemokine Cxcl12/Sdf1 in the Bone Mesenchymal Stem/Progenitor Cells

• Published in: Journal of bone and mineral research Vol. 33; no. 4; pp. 679 - 690
• Main Authors: Tzeng, Yi‐Shiuan, Chung, Ni‐Chun, Chen, Yu‐Ren, Huang, Hsin‐Yi, Chuang, Wen‐Po, Lai, Dar‐Ming
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2018
• Subjects: Adipocytes; Adipogenesis; Adipose tissue; Bone marrow; BONE‐FAT INTERACTIONS; Cancellous bone; Cell interactions; CELL/TISSUE SIGNALING–PARACRINE PATHWAYS; Chemokines; Clonal deletion; CXCL12; CXCL12 protein; CXCR4 protein; Gene deletion; GENETIC ANIMAL MODELS; Hematopoietic stem cells; Homeobox; Homeostasis; Mesenchyme; OSTEOBLAST; Osteoblasts; Osteogenesis; Osteoprogenitor cells; Progenitor cells; Rodents; SDF-1 protein; STROMAL/STEM CELLS; CELL/TISSUE SIGNALING-PARACRINE PATHWAYS; OSTEOBLAST; CXCL12; GENETIC ANIMAL MODELS; STROMAL/STEM CELLS; BONE-FAT INTERACTIONS

ABSTRACT Bone and bone marrow serve as an imperative ecosystem to various types of cells participating in critical body functions. The chemokine Cxcl12, also known as stromal cell‐derived factor 1 (Sdf1), is one of the communication factors in the marrow microenvironment that regulates hematopoietic...