Contribution of a single host genetic locus to mouse adenovirus type 1 infection and encephalitis

• Published in: mBio Vol. 3; no. 3
• Main Authors: Hsu, Tien-Huei, Althaus, Irene W, Foreman, Oded, Spindler, Katherine R
• Format: Journal Article
• Language: English
• Published: United States American Society of Microbiology 2012; American Society for Microbiology
• Subjects: Adenoviridae Infections - genetics; Adenoviridae Infections - veterinary; Adenoviridae Infections - virology; Animals; Encephalitis - genetics; Encephalitis - veterinary; Encephalitis - virology; Female; Genetic Loci; Genetic Predisposition to Disease; Male; Mastadenovirus - physiology; Mice - genetics; Mice - virology; Mice, Inbred BALB C; Rodent Diseases - genetics; Rodent Diseases - microbiology

Susceptibility to mouse adenovirus type 1 (MAV-1) is mouse strain dependent; susceptible mice die from hemorrhagic encephalomyelitis. The MAV-1 susceptibility quantitative trait locus Msq1 accounts for ~40% of the phenotypic (brain viral load) variance that occurs between resistant BALB/c and suscep...