3D super-resolution deep-tissue imaging in living mice

• Published in: Optica Vol. 8; no. 4; pp. 442 - 450
• Main Authors: Velasco, Mary Grace M., Zhang, Mengyang, Antonello, Jacopo, Yuan, Peng, Allgeyer, Edward S., May, Dennis, M’Saad, Ons, Kidd, Phylicia, Barentine, Andrew E. S., Greco, Valentina, Grutzendler, Jaime, Booth, Martin J., Bewersdorf, Joerg
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 20.04.2021

Stimulated emission depletion (STED) microscopy enables the three-dimensional (3D) visualization of dynamic nanoscale structures in living cells, offering unique insights into their organization. However, 3D-STED imaging deep inside biological tissue is obstructed by optical aberrations and light sc...