A translational, caffeine-induced model of onset insomnia in rats and healthy volunteers

• Published in: Psychopharmacologia Vol. 191; no. 4; pp. 943 - 950
• Main Authors: Paterson, Louise M., Wilson, Sue J., Nutt, David J., Hutson, Peter H., Ivarsson, Magnus
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.05.2007; Springer Nature B.V
• Subjects: Adult; Animals; Biological and medical sciences; Caffeine; Central Nervous System Stimulants; Clinical trials; Comparative analysis; Cross-Over Studies; Disease Models, Animal; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Electromyography; GABA Agonists - pharmacology; GABA Agonists - therapeutic use; Human subjects; Humans; Hypnotics and Sedatives - pharmacology; Hypnotics and Sedatives - therapeutic use; Insomnia; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Neuropharmacology; Pharmacology; Pharmacology. Drug treatments; Polysomnography; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Pyridines - pharmacology; Rats; Rats, Sprague-Dawley; Reference Values; Reproducibility of Results; Rodents; Serotonin Uptake Inhibitors - pharmacology; Serotonin Uptake Inhibitors - therapeutic use; Sleep - drug effects; Sleep Initiation and Maintenance Disorders - chemically induced; Sleep Initiation and Maintenance Disorders - physiopathology; Sleep Initiation and Maintenance Disorders - prevention & control; Telemetry; Trazodone - pharmacology; Agonist; Telemetry·Caffeine·Zolpidem· Trazodone Sleep; Rat; Psychotropic; Benzodiazepine receptor; Trazodone; Bicyclic compound; Antidepressant agent; Xanthine derivatives; Neurological disorder; Caffeine; Human; Nervous system diseases; Healthy subject; CNS stimulant; Gabaergic agonist; Rodentia; Sleep disorder; Hypnotic; Polysomnography; Vertebrata; Mammalia; Sleep; Tranquillizer; Insomnia; Animal; Zolpidem; Models; Piperazine derivatives; Gabaergic receptor A; Healthy volunteer- Rat

Insomnia is a common and disabling complaint for which there is a need for improved treatments. Successful drug discovery relies on the use of appropriate animal models to assess likely outcome in the clinic. The purpose of this study was to develop a translational, caffeine-induced model of insomni...