Regulation of Retinal Inflammation by Rhythmic Expression of MiR-146a in Diabetic Retina

• Published in: Investigative ophthalmology & visual science Vol. 55; no. 6; pp. 3986 - 3994
• Main Authors: Wang, Qi, Bozack, Svetlana N., Yan, Yuanqing, Boulton, Michael E., Grant, Maria B., Busik, Julia V.
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 27.05.2014
• Subjects: Animals; Blotting, Western; Cells, Cultured; Circadian Rhythm - physiology; CLOCK Proteins - genetics; Dexamethasone - pharmacology; Diabetes Mellitus, Experimental - genetics; Diabetic Retinopathy - genetics; Endothelial Cells; Gene Expression Regulation - physiology; Glucocorticoids - pharmacology; Intercellular Adhesion Molecule-1 - genetics; Interleukin-1 Receptor-Associated Kinases - genetics; Interleukin-1beta - genetics; Male; MicroRNAs - genetics; Rats; Rats, Long-Evans; Real-Time Polymerase Chain Reaction; Retinal Pigment Epithelium; Retinal Vessels; Retinitis - genetics; RNA, Messenger - genetics; Transfection; Vascular Endothelial Growth Factor A - genetics; inflammatory response; miRNA; endothelial cells; diabetic retinopathy; intercellular adhesion molecule 1; circadian rhythm

Chronic inflammation and dysregulation of circadian rhythmicity are involved in the pathogenesis of diabetic retinopathy. MicroRNAs (miRNAs) can regulate inflammation and circadian clock machinery. We tested the hypothesis that altered daily rhythm of miR-146a expression in diabetes contributes to r...