Amphotericin B Treatment for Indian Visceral Leishmaniasis: Conventional versus Lipid Formulations

• Published in: Clinical infectious diseases Vol. 38; no. 3; pp. 377 - 383
• Main Authors: Sundar, Shyam, Mehta, Himanshu, Suresh, A. V., Singh, Shri P., Madhukar, Rai, Murray, Henry W.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.02.2004; University of Chicago Press
• Subjects: Adolescent; Adult; amphotericin B; Amphotericin B - adverse effects; Amphotericin B - therapeutic use; amphotericin B deoxycholate; Animals; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antiprotozoal Agents - adverse effects; Antiprotozoal Agents - therapeutic use; Biological and medical sciences; Child; Child, Preschool; Cost estimates; Deoxycholic Acid - adverse effects; Deoxycholic Acid - therapeutic use; Diseases; Dosage; Drug Combinations; Drug Costs; Female; Fever; Hemoglobins; Hospital Costs; Human protozoal diseases; Humans; India - epidemiology; Infant; Infectious diseases; Leishmania; Leishmaniasis, Visceral - drug therapy; Leishmaniasis, Visceral - epidemiology; Leshmaniasis; Lipids; Liposomes; Major Articles; Male; Medical cures; Medical sciences; Middle Aged; Parasites; Parasitic diseases; Pharmacology. Drug treatments; Phosphatidylcholines - adverse effects; Phosphatidylcholines - therapeutic use; Phosphatidylglycerols - adverse effects; Phosphatidylglycerols - therapeutic use; Protozoal diseases; Treatment Outcome; Visceral leishmaniasis; Bihar; Asia; India; Human; Protozoal disease; Costs; Relapse; Cure; Rate; Kala azar; Lipids; Leishmaniasis; Parasitosis; Complex lipid; Infection; Antiprotozoal agent; Antibiotic; Antifungal agent; Treatment; Amphotericin B; Polyenic compound; Health economy; Dosage form; Parasiticide; Indian; Public health; Comparative study

In Bihar, India, where visceral leishmaniasis is hyperendemic, amphotericin B deoxycholate is now first-line parenteral treatment. To test the efficacy of amphotericin B deoxycholate versus that of its lipid formulations, Indian patients were randomized to receive treatment with amphotericin B deoxy...