Foxd1 is a mediator and indicator of the cell reprogramming process

• Published in: Nature communications Vol. 5; no. 1; p. 3197
• Main Authors: Koga, Makito, Matsuda, Mitsuhiro, Kawamura, Teruhisa, Sogo, Takahiro, Shigeno, Asako, Nishida, Eisuke, Ebisuya, Miki
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.02.2014; Nature Publishing Group
• Subjects: 13/31; 38/61; 631/136/532/2435; 631/337; 631/532/2064/2158; Animals; Cellular Reprogramming; Forkhead Box Protein O1; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Gene Expression Regulation; Gene Knockdown Techniques; HEK293 Cells; Humanities and Social Sciences; Humans; Mice, Inbred C57BL; Mice, Inbred ICR; multidisciplinary; Science; Science (multidisciplinary)

It remains unclear how changes in gene expression profiles that establish a pluripotent state are induced during cell reprogramming. Here we identify two forkhead box transcription factors, Foxd1 and Foxo1, as mediators of gene expression programme changes during reprogramming. Knockdown of Foxd1 or...