Prognostic relevance of genetic alterations in diffuse lower-grade gliomas

• Published in: Neuro-oncology (Charlottesville, Va.) Vol. 20; no. 1; pp. 66 - 77
• Main Authors: Aoki, Kosuke, Nakamura, Hideo, Suzuki, Hiromichi, Matsuo, Keitaro, Kataoka, Keisuke, Shimamura, Teppei, Motomura, Kazuya, Ohka, Fumiharu, Shiina, Satoshi, Yamamoto, Takashi, Nagata, Yasunobu, Yoshizato, Tetsuichi, Mizoguchi, Masahiro, Abe, Tatsuya, Momii, Yasutomo, Muragaki, Yoshihiro, Watanabe, Reiko, Ito, Ichiro, Sanada, Masashi, Yajima, Hironori, Morita, Naoya, Takeuchi, Ichiro, Miyano, Satoru, Wakabayashi, Toshihiko, Ogawa, Seishi, Natsume, Atsushi
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 10.01.2018
• Subjects: Basic and Translational Investigations; prognostic factor; diffuse lower-grade glioma; genetic alteration

Diffuse lower-grade gliomas (LGGs) are genetically classified into 3 distinct subtypes based on isocitrate dehydrogenase (IDH) mutation status and codeletion of chromosome 1p and 19q (1p/19q). However, the subtype-specific effects of additional genetic lesions on survival are largely unknown. Using...