Plasticity and redundancy among AMA–RON pairs ensure host cell entry of Toxoplasma parasites

• Published in: Nature communications Vol. 5; no. 1; p. 4098
• Main Authors: Lamarque, Mauld H., Roques, Magali, Kong-Hap, Marie, Tonkin, Michelle L., Rugarabamu, George, Marq, Jean-Baptiste, Penarete-Vargas, Diana M., Boulanger, Martin J., Soldati-Favre, Dominique, Lebrun, Maryse
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.06.2014; Nature Publishing Group
• Subjects: 14/63; 38/109; 38/70; 38/77; 631/250/255/1715; 631/80/304; Antigens, Protozoan - genetics; Antigens, Protozoan - metabolism; Gene Deletion; Genetics; Humanities and Social Sciences; Humans; Infectious diseases; Malaria; Models, Molecular; multidisciplinary; Parasites; Plasticity; Protein Binding; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Science; Science (multidisciplinary); Toxoplasma - genetics; Toxoplasma - metabolism; Toxoplasma - pathogenicity; Toxoplasmosis; Toxoplasmosis - parasitology; Vector-borne diseases; Virulence

Malaria and toxoplasmosis are infectious diseases caused by the apicomplexan parasites Plasmodium and Toxoplasma gondii , respectively. These parasites have developed an invasion mechanism involving the formation of a moving junction (MJ) that anchors the parasite to the host cell and forms a ring t...