Annatto constituent cis-bixin has selective antimyeloma effects mediated by oxidative stress and associated with inhibition of thioredoxin and thioredoxin reductase

• Published in: Antioxidants & redox signaling Vol. 13; no. 7; p. 987
• Main Authors: Tibodeau, Jennifer D, Isham, Crescent R, Bible, Keith C
• Format: Journal Article
• Language: English
• Published: United States 01.10.2010
• Subjects: Acetylcysteine - metabolism; Acetylcysteine - pharmacology; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis - drug effects; Bixaceae; Carotenoids - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Drug Screening Assays, Antitumor; Glutathione - metabolism; Glutathione - pharmacology; Humans; Multiple Myeloma - drug therapy; Multiple Myeloma - pathology; Oxidation-Reduction; Oxidative Stress - drug effects; Phytotherapy; Plant Extracts; Reactive Oxygen Species - metabolism; Seeds; Thioredoxin-Disulfide Reductase - antagonists & inhibitors; Thioredoxin-Disulfide Reductase - metabolism; Thioredoxins - antagonists & inhibitors; Thioredoxins - metabolism

In pursuit of the anticancer effects of seeds of the rain forest plant Bixa orellana (annatto), we found that its constituent cis-bixin induced cytotoxicity in a wide variety of tumor cell lines (IC(50) values from 10 to 50 microM, 24-h exposures) and, importantly, also selectively killed freshly co...