Long noncoding RNA GAS5 inhibits cell proliferation and fibrosis in diabetic nephropathy by sponging miR-221 and modulating SIRT1 expression

• Published in: Aging (Albany, NY.) Vol. 11; no. 20; pp. 8745 - 8759
• Main Authors: Ge, Xiaoxu, Xu, Bojin, Xu, Wenwei, Xia, Lili, Xu, Zhongqin, Shen, Lisha, Peng, Wenfang, Huang, Shan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals 20.10.2019
• Subjects: Research Paper; fibrosis; proliferation; diabetic nephropathy; lncRNA GAS5

Diabetic nephropathy (DN) is one of the leading causes of end-stage renal diseases worldwide. This study is designed to investigate the underlying function and mechanism of a novel lncRNA GAS5 in the progression of DN. We found that lncRNA GAS5 expression level was decreased in type 2 diabetes (T2D)...