The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines

• Published in: Phytochemistry (Oxford) Vol. 117; pp. 332 - 339
• Main Authors: De Ford, Christian, Ulloa, Jerónimo L., Catalán, César A.N., Grau, Alfredo, Martino, Virginia S., Muschietti, Liliana V., Merfort, Irmgard
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.09.2015; Elsevier
• Subjects: Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - pharmacology; apoptosis; Asteraceae; Asteraceae - chemistry; Biochemistry & Molecular Biology; Cell Cycle - drug effects; Cell Death - drug effects; Cell Line, Tumor - drug effects; Cytotoxicity; Drug Evaluation, Preclinical - methods; Drug Screening Assays, Antitumor - methods; Humans; Lactones - chemistry; Lactones - pharmacology; leaves; leukemia; Leukemia, T-Cell - drug therapy; Leukemia, T-Cell - pathology; Leukocytes, Mononuclear - drug effects; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; mechanism of action; Molecular Structure; mononuclear leukocytes; necrosis; neoplasm cells; nuclear magnetic resonance spectroscopy; oxidative stress; Oxidative Stress - drug effects; pancreatic neoplasms; Plant Sciences; reactive oxygen species; Science & Technology; Sesquiterpene lactones; Sesquiterpenes - chemistry; Sesquiterpenes - pharmacology; Sesquiterpenes, Germacrane - chemistry; Sesquiterpenes, Germacrane - pharmacology; sesquiterpenoid lactones; Smallanthus sonchifolius; Cytotoxicity; Sesquiterpene lactones; Smallanthus sonchifolius; Asteraceae; APOPTOSIS; ASSAY; LEAVES; OCCURRING TERPENE DERIVATIVES; INHIBITION; CYTO-TOXICITY; GUAIANOLIDES; GERMACRANOLIDES; MELAMPOLIDES; CONSTITUENTS

The sesquiterpene lactone polymatin B induces different mechanisms of cell death which is dependent on the cell type. Preferentially, cell death is promoted by inducing oxidative stress in cancer cells. [Display omitted] •An acanthospermolide sesquiterpene lactone (SL) has been identified in Smallan...