Noncanonical regulation of phosphatidylserine metabolism by a Sec14-like protein and a lipid kinase

• Published in: The Journal of cell biology Vol. 219; no. 5
• Main Authors: Wang, Yaxi, Yuan, Peihua, Grabon, Aby, Tripathi, Ashutosh, Lee, Dongju, Rodriguez, Martin, Lönnfors, Max, Eisenberg-Bord, Michal, Wang, Zehua, Man Lam, Sin, Schuldiner, Maya, Bankaitis, Vytas A.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 04.05.2020
• Subjects: 1-Phosphatidylinositol 4-Kinase - genetics; Biological Transport - genetics; Cell Metabolism; Lipid Metabolism - genetics; Membrane Proteins - genetics; Metabolism; Phosphatidylethanolamines - genetics; Phosphatidylethanolamines - metabolism; Phosphatidylserines - genetics; Phosphatidylserines - metabolism; Phospholipid Transfer Proteins - genetics; Saccharomyces cerevisiae - genetics; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - genetics

The yeast phosphatidylserine (PtdSer) decarboxylase Psd2 is proposed to engage in a membrane contact site (MCS) for PtdSer decarboxylation to phosphatidylethanolamine (PtdEtn). This proposed MCS harbors Psd2, the Sec14-like phosphatidylinositol transfer protein (PITP) Sfh4, the Stt4 phosphatidylinos...