The Mechanism of Rac1 in Regulating HCC Cell Glycolysis Which Provides Underlying Therapeutic Target for HCC Therapy

• Published in: Journal of oncology Vol. 2022; pp. 1 - 15
• Main Authors: Ren, Yin-Xiang, Li, Xiao-Bin, Liu, Wei, Yang, Xu-Guang, Liu, Xin, Luo, Yu
• Format: Journal Article
• Language: English
• Published: New York Hindawi 06.07.2022; John Wiley & Sons, Inc
• Subjects: Apoptosis; Cancer therapies; Drug resistance; Glucose metabolism; Health aspects; Inhibitor drugs; Leukemia; Liver cancer; Lung cancer; Medical prognosis; Metastasis; Patients; Physiological aspects; Proteins; Stem cells; Targeted cancer therapy; Tumors; Wound healing; China

Aim. To explore the role of Rac1 on sorafenib resistance in hepatocellular carcinoma. Methods. CCK-8, wound healing assay, Transwell, and cell cycle assay were used to detect the tumor cells development. Cell viability was assessed by MTT. The glycolytic pathway was revealed by cellular metabolism a...