CXCL10 Acts as a Bifunctional Antimicrobial Molecule against Bacillus anthracis

• Published in: mBio Vol. 7; no. 3
• Main Authors: Margulieux, Katie R, Fox, Jay W, Nakamoto, Robert K, Hughes, Molly A
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 10.05.2016
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Bacillus anthracis - drug effects; Bacillus anthracis - genetics; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Proteins - pharmacology; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Chemokine CXCL10 - chemistry; Chemokine CXCL10 - genetics; Chemokine CXCL10 - metabolism; Chemokine CXCL10 - pharmacology; Humans; Membrane Potentials - drug effects; Mutation; Protein Binding; Sequence Alignment

Bacillus anthracis is killed by the interferon-inducible, ELR(-) CXC chemokine CXCL10. Previous studies showed that disruption of the gene encoding FtsX, a conserved membrane component of the ATP-binding cassette transporter-like complex FtsE/X, resulted in resistance to CXCL10. FtsX exhibits some s...