Sulfamoyl Heteroarylcarboxylic Acids as Promising Metallo-β-Lactamase Inhibitors for Controlling Bacterial Carbapenem Resistance

• Published in: mBio Vol. 11; no. 2
• Main Authors: Wachino, Jun-Ichi, Jin, Wanchun, Kimura, Kouji, Kurosaki, Hiromasa, Sato, Ayato, Arakawa, Yoshichika
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 17.03.2020
• Subjects: Acinetobacter - drug effects; Animals; Anti-Bacterial Agents - pharmacology; beta-Lactamase Inhibitors - chemical synthesis; beta-Lactamase Inhibitors - pharmacology; carbapenems; Carbapenems - pharmacology; Carboxylic Acids - chemistry; Carboxylic Acids - pharmacology; Cell Line; CRE; Drug Discovery; Drug Resistance, Bacterial; Enterobacteriaceae - drug effects; Escherichia coli - drug effects; Humans; Male; Meropenem - pharmacology; metallo-β-lactamase; Mice; Microbial Sensitivity Tests; Microsomes, Liver - drug effects; Pseudomonas aeruginosa - drug effects; sulfamoyl heteroarylcarboxylic acids; Therapeutics and Prevention; carbapenems; sulfamoyl heteroarylcarboxylic acids; metallo-β-lactamase; CRE

Production of metallo-β-lactamases (MBLs), which hydrolyze carbapenems, is a cause of carbapenem resistance in Development of effective inhibitors for MBLs is one approach to restore carbapenem efficacy in carbapenem-resistant (CRE). We report here that sulfamoyl heteroarylcarboxylic acids (SHCs) ca...