The Mediterranean diet protects against waist circumference enlargement in 12Ala carriers for the PPARγ gene: 2 years' follow-up of 774 subjects at high cardiovascular risk

• Published in: British journal of nutrition Vol. 102; no. 5; pp. 672 - 679
• Main Authors: Razquin, Cristina, Alfredo Martinez, J., Martinez-Gonzalez, Miguel A., Corella, Dolores, Santos, José Manuel, Marti, Amelia
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 14.09.2009
• Subjects: Adipogenesis; Adipose tissue; Alleles; Cardiovascular diseases; Diabetes; Diabetes mellitus; Diet; disease prevention; fat accumulation; Gene polymorphism; Genes; Genetic epidemiology; genetic polymorphism; Genetic testing; genotype; Health risks; high risk subjects; human genetics; insulin resistance; Intervention; lipogenesis; Low fat diet; Mediterranean diet; Molecular Nutrition; Nutrient deficiency; Nutrition research; Nuts; Olive oil; Overweight; Peroxisome proliferator-activated receptors; polymerase chain reaction; Polymorphism; Population genetics; PPARy gene; PPARγ; Restriction fragment length polymorphism; Risk; Standard deviation; Statistical analysis; transcription factors; Variables; Waist circumference; Waist circumference; Genetic epidemiology; Mediterranean diet; PPARγ
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1017/S0007114509289008

The PPARγ gene regulates insulin sensitivity and adipogenesis. The Pro12Ala polymorphism of this gene has been related to fat accumulation. Our aim was to analyse the effects of a 2-year nutritional intervention with Mediterranean-style diets on adiposity in high-cardiovascular risk patients dependi...