A review of Mendelian randomization in amyotrophic lateral sclerosis

• Published in: Brain (London, England : 1878) Vol. 145; no. 3; pp. 832 - 842
• Main Authors: Julian, Thomas H, Boddy, Sarah, Islam, Mahjabin, Kurz, Julian, Whittaker, Katherine J, Moll, Tobias, Harvey, Calum, Zhang, Sai, Snyder, Michael P, McDermott, Christopher, Cooper-Knock, Johnathan, Shaw, Pamela J
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 29.04.2022
• Subjects: Amyotrophic Lateral Sclerosis - genetics; Diabetes Mellitus, Type 2; Genome-Wide Association Study - methods; Humans; Lipids; Mendelian Randomization Analysis - methods; Neurodegenerative Diseases; Reproducibility of Results; Review; epidemiology; amyotrophic lateral sclerosis; Mendelian randomization

Amyotrophic lateral sclerosis is a relatively common and rapidly progressive neurodegenerative disease that, in the majority of cases, is thought to be determined by a complex gene-environment interaction. Exponential growth in the number of performed genome-wide association studies combined with th...