Filamentous bacteriophage delays healing of Pseudomonas-infected wounds

• Published in: Cell reports. Medicine Vol. 3; no. 6; p. 100656
• Main Authors: Bach, Michelle S., de Vries, Christiaan R., Khosravi, Arya, Sweere, Johanna M., Popescu, Medeea C., Chen, Qingquan, Demirdjian, Sally, Hargil, Aviv, Van Belleghem, Jonas D., Kaber, Gernot, Hajfathalian, Maryam, Burgener, Elizabeth B., Liu, Dan, Tran, Quynh-Lam, Dharmaraj, Tejas, Birukova, Maria, Sunkari, Vivekananda, Balaji, Swathi, Ghosh, Nandini, Mathew-Steiner, Shomita S., El Masry, Mohamed S., Keswani, Sundeep G., Banaei, Niaz, Nedelec, Laurence, Sen, Chandan K., Chandra, Venita, Secor, Patrick R., Suh, Gina A., Bollyky, Paul L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.06.2022; Elsevier
• Subjects: Animals; bacteriophage; Biofilms; filamentous phage; Humans; immunology; Inovirus; Mammals; microbiology; Prospective Studies; Pseudomonas; Pseudomonas aeruginosa; Pseudomonas Infections - therapy; Wound Healing; Wound Infection - therapy; wounds; wounds; Pf; microbiology; Pseudomonas; bacteriophage; immunology; filamentous phage
• ISSN: 2666-3791; 2666-3791
• DOI: 10.1016/j.xcrm.2022.100656

Chronic wounds infected by Pseudomonas aeruginosa (Pa) are characterized by disease progression and increased mortality. We reveal Pf, a bacteriophage produced by Pa that delays healing of chronically infected wounds in human subjects and animal models of disease. Interestingly, impairment of wound...