Protein stabilization by cyclodextrins in the liquid and dried state

• Published in: Advanced drug delivery reviews Vol. 63; no. 13; pp. 1086 - 1106
• Main Authors: Serno, Tim, Geidobler, Raimund, Winter, Gerhard
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2011
• Subjects: Animals; Cavities; Cyclodextrin; Cyclodextrins - chemistry; Drug Design; Drug Stability; Excipients - chemistry; HPβCD; Humans; Hydrophobic and Hydrophilic Interactions; Injections; Liquid formulation; Lyophilization; Monoclonal antibody; Non-ionic surfactant; Protein; Protein aggregation; Protein formulation; Protein stabilization; Proteins - administration & dosage; Proteins - chemistry; Cyclodextrin; Protein aggregation; Non-ionic surfactant; HPβCD; Liquid formulation; Lyophilization; Monoclonal antibody; Protein formulation; Protein; Protein stabilization

Aggregation is arguably the biggest challenge for the development of stable formulations and robust manufacturing processes of therapeutic proteins. In search of novel excipients inhibiting protein aggregation, cyclodextrins and their derivatives have been under examination for use in parenteral pro...