Low serum free IL-18 is a novel potential marker for predicting infectious events in patients at dialysis initiation
Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] conce...
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| Published in | Clinical kidney journal Vol. 18; no. 5; p. sfaf094 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Oxford University Press
01.05.2025
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| Abstract | Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk.
The Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan-Meier curves of the "low" and "high" serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis.
We analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 ± 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test
< .01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events.
A low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients. |
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| AbstractList | Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk.BackgroundCompared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk.The Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan-Meier curves of the "low" and "high" serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis.MethodsThe Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan-Meier curves of the "low" and "high" serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis.We analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 ± 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test P < .01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events.ResultsWe analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 ± 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test P < .01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events.A low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients.ConclusionA low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients. Background. Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk. Methods. The Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan-Meier curves of the "low" and "high" serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis. Results. We analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 [+ or -] 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test P <.01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events. Conclusion. A low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients. Keywords: dialysis initiation, free IL-18, infection, multicenter prospective cohort study Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their mortality rate from infectious diseases is also higher. We investigated the serum free interleukin-18 [free state of interleukin-18 (IL-18)] concentration as a prognostic factor for hemodialysis patients' infection risk. The Ibaraki Dialysis Initiation Cohort (iDIC) study is a multicenter prospective cohort investigation of patients undergoing a new initiation of dialysis in a local region of Japan. We performed a survival analysis of several events requiring hospitalization and compared the Kaplan-Meier curves of the "low" and "high" serum free IL-18 concentration groups. To adjust for confounding factors, we also performed a Cox proportional hazards analysis. We analyzed the serum free IL-18 concentration of samples from 295 patients randomly selected from the blood sample bank of the iDIC study. The mean free IL-18 concentration was 8.7 ± 5.3 pmol/l. The cumulative incidence of infectious events was significantly higher in the low free IL-18 group (<6.0 pmol/l, log-rank test < .01). The Cox proportional hazards analysis revealed that low serum free IL-18 (<6.0 pmol/l) was an independent factor associated with the development of infectious events. Total IL-18 and IL-18BP (binding protein) showed no association with infectious events. A low serum free IL-18 concentration in the dialysis initiation period is a potential marker for predicting the development of severe infection in these patients. |
| Audience | Academic |
| Author | Shiraishi, Takeshi Ono, Atsushi Shiigai, Tatsuo Yamada, Kota Ogura, Yasunobu Kondo, Tadashi Yamagata, Kunihiro Tokoi, Minoru Takeda, Atsushi Iwamoto, Hitoshi Fujii, Toshihiro Ookawa, Hiroshi Ebihara, Itaru Issiki, Koichi Takahashi, Tokuo Usui, Joichi Nishiki, Kenta Kubo, Masashi Shima, Masayoshi Ohishi, Akira Tachibana, Hisaya Akai, Youichi Hayakawa, Masahiro Tawara-Iida, Takashi Kashiwabara, Hidehiko Hoshino, Takanobu Kobayashi, Masaki Maeda, Nobuki Kanekawa, Takuro Takita, Takashi Yamaguchi, Tetsu Maeda, Yoshitaka Takahashi, Ikuo Ishizu, Takashi Takasaki, Hideaki Saito, Takako Takada, Kenji Kaneda, Fumika Tsuruta, Atsushi Matsukawa, Hideki Deguchi, Masao Nakajima, Masami Honma, Sumiko Iwabuchi, Satoshi Yuhara, Takamichi Ooba, Syoji Hiroi, Makoto Tsunematsu, Sadao Ishizuka, Genzou Ohtsuka, Masakazu Kobayashi, Hiroaki Iitsuka, Tadashi Nakamura, Hideko Kanamori, Naoaki Kikuchi, Hiroshi Kozaki, Koichi Kurosawa, Hiromi |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40322680$$D View this record in MEDLINE/PubMed |
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| ContentType | Journal Article |
| Contributor | Shiraishi, Takeshi Ono, Atsushi Shiigai, Tatsuo Yamada, Kota Ogura, Yasunobu Kondo, Tadashi Tokoi, Minoru Takeda, Atsushi Iwamoto, Hitoshi Fujii, Toshihiro Ookawa, Hiroshi Issiki, Koichi Takahashi, Tokuo Nishiki, Kenta Kubo, Masashi Shima, Masayoshi Ohishi, Akira Tachibana, Hisaya Akai, Youichi Hayakawa, Masahiro Kashiwabara, Hidehiko Hoshino, Takanobu Maeda, Nobuki Kanekawa, Takuro Takita, Takashi Yamaguchi, Tetsu Takahashi, Ikuo Takasaki, Hideaki Ishizu, Takashi Saito, Takako Takada, Kenji Kaneda, Fumika Tsuruta, Atsushi Matsukawa, Hideki Deguchi, Masao Nakajima, Masami Honma, Sumiko Iwabuchi, Satoshi Yuhara, Takamichi Ooba, Syoji Hiroi, Makoto Tsunematsu, Sadao Ishizuka, Genzou Ohtsuka, Masakazu Iitsuka, Tadashi Nakamura, Hideko Kanamori, Naoaki Kikuchi, Hiroshi Kozaki, Koichi Kurosawa, Hiromi |
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| Copyright | The Author(s) 2025. Published by Oxford University Press on behalf of the ERA. COPYRIGHT 2025 Oxford University Press The Author(s) 2025. Published by Oxford University Press on behalf of the ERA. 2025 |
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| Keywords | infection dialysis initiation multicenter prospective cohort study free IL-18 |
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| Snippet | Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and their... Background. Compared to the general population, individuals who are undergoing hemodialysis are at a higher risk of contracting severe infectious diseases, and... |
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| SubjectTerms | Analysis Communicable diseases Development and progression Health aspects Infection Interleukins Japan Medical research Medicine, Experimental Mortality Original Prognosis Protein binding Rankings |
| Title | Low serum free IL-18 is a novel potential marker for predicting infectious events in patients at dialysis initiation |
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